Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Jiunn H. Lin"'
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 4, Iss 4, Pp 270-278 (2014)
An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 (CYP) enzymes. This method employed a cocktail of six probe substrates (i.e., phenacetin, amodiaqu
Externí odkaz:
https://doaj.org/article/adb69f77ef02440e99e840002953a1b0
Autor:
William C. Mobley, Robert A. Rissman, Gopal Thinakaran, Brian P. Head, Rudolph E. Tanzi, Steven K. Duddy, Yuhuan Xie, Moorthi Ponnusamy, Michael Mante, Jiunn H. Lin, Olga Prikhodko, Ann Becker, Brian Spencer, Kevin D. Rynearson, Steven L. Wagner, Brenda Hug, Douglas Galasko, Graham Johnson, Bahar Salehi, Jazmin Florio, Can Zhang, Mariko Sawa, Carlos Arias, Phuong Nguyen
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol 218, iss 4
Journal of Experimental Medicine, vol 218, iss 4
GSMs preferentially attenuate levels of the aggregation-prone Aβ42 peptide by binding to the γ-secretase enzyme and altering exopeptidase-like processing. Rynearson et al. demonstrate the ability of an advanced-stage GSM to robustly attenuate Aβ42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c02e75bda1fdeb22284485c3ed260
http://europepmc.org/articles/PMC7931646
http://europepmc.org/articles/PMC7931646
Publikováno v:
Current Pharmacology Reports. 4:10-26
Antibody drug conjugates (ADCs) are a class of powerful anti-cancer therapeutics composed of a potent cytotoxic drug, a cancer cell-targeting monoclonal antibody (mAb), and a linker connecting the drug to the antibody. Despite often being referred to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bb1a755cefda9e9ed1fdea765695a01
https://doi.org/10.1007/s40495-018-0122-9
https://doi.org/10.1007/s40495-018-0122-9
Publikováno v:
Handbook of Drug Metabolism ISBN: 9780429190315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e26640d0d14ecb18c1296fc394a9ff
https://doi.org/10.1201/9780429190315-22
https://doi.org/10.1201/9780429190315-22
Autor:
Jiunn H. Lin
Publikováno v:
Drug-Drug Interactions ISBN: 9780429131967
Drug-Drug Interactions in Pharmaceutical Development
Drug-Drug Interactions in Pharmaceutical Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7655e00c898add62a218bb0c72cdfe
https://doi.org/10.1201/9780429131967-12
https://doi.org/10.1201/9780429131967-12
Autor:
Robert A. Rissman, Phuong Nguyen, Weiming Xia, Doo Yeon Kim, Deborah Masliah, Steven K. Duddy, Louise Monte, Ann Becker, Graham Johnson, Jiunn H. Lin, Can Zhang, Kevin D. Rynearson, William C. Mobley, Corinne M. Echmalian, Rudolph E. Tanzi, Steven L. Wagner, Uyen Vo, Justin B. Klee, Luisa Quinti
Publikováno v:
The Journal of pharmacology and experimental therapeutics, vol 362, iss 1
The Journal of Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics
Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid-β peptide (Aβ), as well as 2) neurofibrillary tangles composed of aggregates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a46fd75288db093dbde82421751825
https://escholarship.org/uc/item/6n31h1k9
https://escholarship.org/uc/item/6n31h1k9
Publikováno v:
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis, Vol 4, Iss 4, Pp 270-278 (2014)
Journal of Pharmaceutical Analysis, Vol 4, Iss 4, Pp 270-278 (2014)
An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 (CYP) enzymes. This method employed a cocktail of six probe substrates (i.e., phenacetin, amodiaqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00ced12a17dfb7a705cf4c06bdec8a2
Autor:
C. Charles Lin, Jiunn H. Lin, James A. Yergey, Wei Tang, A. David Rodrigues, Bradley K. Wong, Ping Lu, Thomas A. Baillie, Jason S. Ngui, Qin Mei, Cuyue Tang, Rominder Singh, Thomas H. Rushmore, Paul G. Pearson, Dan Cui, Yuh Lin, Magang Shou
Publikováno v:
Current Drug Metabolism. 2:17-36
The most common drug-drug interactions may be understood in terms of alterations of metabolism, associated primarily with changes in the activity of cytochrome P450 (CYP) enzymes. Kinetic parameters such as K m , V max , K i and K a , which describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20285ed6becc136191602e0cbf544d2
https://doi.org/10.2174/1389200013338784
https://doi.org/10.2174/1389200013338784
Autor:
Jiunn H. Lin, Weirong Wang
Publikováno v:
Pharmaceutical Sciences Encyclopedia
Therapeutic proteins can only be injected by parenteral routes, including intravenous (IV) and subcutaneous (SC) injection. It is highly desirable for therapeutic proteins to be self-administered SC, than by IV injection, by patient themselves, thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95bda5b91d3b92e98fe1526277ac282f
https://doi.org/10.1002/9780470571224.pse541
https://doi.org/10.1002/9780470571224.pse541
Autor:
Jiunn H. Lin
Publikováno v:
Current Drug Metabolism. 9:46-59
For drugs that directly act on targets in the central nervous system (CNS), sufficient drug delivery into the brain is a prerequisite for drug action. Systemically administered drugs can reach CNS by passage across the endothelium of capillary vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b009797a1664eb7b7970388f64f8ac7
https://doi.org/10.2174/138920008783331077
https://doi.org/10.2174/138920008783331077