Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jiun-Shyang Leou"'
Autor:
Jiun-Shyang Leou, 柳鈞翔
92
Protein arginine methylation has been recently implicated as a novel mechanism in cell growth control, gene express regulation, signal transduction and protein intracellular localization. In this study, we examined whether protein methylation
Protein arginine methylation has been recently implicated as a novel mechanism in cell growth control, gene express regulation, signal transduction and protein intracellular localization. In this study, we examined whether protein methylation
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/30439707086404756501
Autor:
Kuan-Hung Chen, Pi-Chun Li, Chung-Tao Tang, Jiun-Shyang Leou, Chao-Min Cheng, Han-Chung Wu, Yin-Liang Tang, Hsi-Kai Wang, Cheng-Han Tsai, Hsyue-Jen Hsieh
Publikováno v:
Advanced Healthcare Materials. 3:187-196
Here, two types of cellulose-based in vitro diagnostic devices are demonstrated for the diagnosis of dengue virus infection in both buffer system and human serum: 1) paper-based ELISA for providing the semiquantitative information of the disease acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c02ddef837fa321b6dd4a57e217bd0f
https://doi.org/10.1002/adhm.201300150
https://doi.org/10.1002/adhm.201300150
Autor:
John T.A. Hsu, Tzu Wen Lien, Xin Chen, Jiun Shyang Leou, Chia Hui Lin, Yi Hui Peng, Wen-Hsing Lin, Jian Sung Wu, Chien Fu Huang, Yu-Sheng Chao, Hsing Pang Hsieh, Su Ying Wu, Hui Yi Shiao, Mohane Selvaraj Coumar, Ping-Chiang Lyu
Publikováno v:
ChemMedChem. 5:1707-1716
The need to develop safer and more effective antidiabetic drugs is essential owing to the growth worldwide of the diabetic population. Targeting the PPAR receptor is one strategy for the treatment of diabetes; the PPAR agonists rosiglitazone and piog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0fdd812416a9c74611f97bb7b7b244
https://doi.org/10.1002/cmdc.201000194
https://doi.org/10.1002/cmdc.201000194
Autor:
Ping-Chiang Lyu, Ching-Chuan Kuo, Ming-Hsine Wu, Yu-Shan Wu, Jen-Shin Song, Jiun-Shyang Leou, Huan-Yi Jseng, Su-Ying Wu, Hsing Pang Hsieh, Chi-Yen Chang, Yu-Sheng Chao, Chung-Tong Chen, Jang Yang Chang, Yi-Kun Chiang, Jian-Sung Wu, Mohane Selvaraj Coumar
Publikováno v:
Journal of Medicinal Chemistry. 52:4221-4233
A pharmacophore model, Hypo1, was built on the basis of 21 training-set indole compounds with varying levels of antiproliferative activity. Hypo1 possessed important chemical features required for the inhibitors and demonstrated good predictive abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd366b3cf3e69c02a6140e6ca22457b
https://doi.org/10.1021/jm801649y
https://doi.org/10.1021/jm801649y
Autor:
Jian Sung Wu, Hsing Pang Hsieh, Wen-Hsing Lin, Jiun Shyang Leou, Yu-Sheng Chao, Chun Yu Chang, Uan Kang Tan, John T.A. Hsu, Paritosh Shukla, Su Ying Wu, Mohane Selvaraj Coumar, Chun Hwa Chen, Tzu Wen Lien, Ajay Kumar Dixit
Publikováno v:
Journal of Medicinal Chemistry. 52:1050-1062
Aurora kinases have emerged as attractive targets for the design of anticancer drugs. Through structure-based virtual screening, novel pyrazole hit 8a was identified as Aurora kinase A inhibitor (IC(50) = 15.1 microM). X-ray cocrystal structure of 8a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970481416dd7ba6161a87fb9cce9ef21
https://doi.org/10.1021/jm801270e
https://doi.org/10.1021/jm801270e
Autor:
Pi-Chun Li, Cheng-Han Tsai, Jiun-Shyang Leou, Chung-Tao Tang, Chao-Min Cheng, Hsyue-Jen Hsieh, Han-Chung Wu, Yin-Liang Tang, Hsi-Kai Wang
Publikováno v:
NEMS
Dengue fever is one of the acute flavivrus-borne infectious diseases caused by dengue virus with four serotypes. To date, there are no efficient diagnostic tools available for monitoring the disease activity of dengue fever. It is needed to develop a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf03f33c3788dbb93b711e6baa350ab7
https://doi.org/10.1109/nems.2013.6559721
https://doi.org/10.1109/nems.2013.6559721
Autor:
Hsing Pang Hsieh, Yu-Sheng Chao, Tzu-Wen Lien, Jen-Shin Song, Yun-Lung Ho, Ming-Yu Fang, Wen-Hsing Lin, Chun-Chen Liao, John T.A. Hsu, Chang-Ying Chu, Cheng-Wei Lin, Jiun-Shyang Leou, Szu-Huei Wu, Santhosh Kumar Chittimalla, Chin-Ting Huang, Randheer Reddy, Chun-Hwa Chen, Yi-Hui Peng, Jian-Sung Wu, Hui Yi Shiao, Su-Ying Wu, Mohane Selvaraj Coumar
Publikováno v:
Journal of medicinal chemistry. 53(13)
A focused library of furanopyrimidine (350 compounds) was rapidly synthesized in parallel reactors and in situ screened for Aurora and epidermal growth factor receptor (EGFR) kinase activity, leading to the identification of some interesting hits. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba2fd158eeddb8e8a6730aa550364dc
https://pubmed.ncbi.nlm.nih.gov/20550212
https://pubmed.ncbi.nlm.nih.gov/20550212
Autor:
Chih Jen Kuan, Yuan I. Chang, Chao-Ling Yao, Jiun Shyang Leou, Yi Chi Hung, Shiaw-Min Hwang, Wei Kai Hua, Wey Jinq Lin
Publikováno v:
The Journal of biological chemistry. 285(27)
Protein-arginine methyltransferase 1 (PRMT1) plays pivotal roles in various cellular processes. However, its role in megakaryocytic differentiation has yet to be investigated. Human leukemia K562 cells have been used as a model to study hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208b696105f50dda92460043b7fb6926
https://pubmed.ncbi.nlm.nih.gov/20442406
https://pubmed.ncbi.nlm.nih.gov/20442406
Autor:
Biing-Jiun Uang, Hsing Pang Hsieh, Ming Yu Fang, John T.A. Hsu, Chun Hwa Chen, Jian Sung Wu, Ming Tsung Tsai, Su Ying Wu, Wen-Hsing Lin, Chi Huang Teng, Chang Ying Chu, Yu-Sheng Chao, Teng Yuan Chang, Jiun Shyang Leou, Chun Yu Chang, Mohane Selvaraj Coumar
Publikováno v:
ChemMedChem. 5(2)
Herein we reveal a simple method for the identification of novel Aurora kinase A inhibitors through substructure searching of an in-house compound library to select compounds for testing. A hydrazone fragment conferring Aurora kinase activity and het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed68da99234a4a00105a8a7a19a62440
https://pubmed.ncbi.nlm.nih.gov/20039358
https://pubmed.ncbi.nlm.nih.gov/20039358
Autor:
Mohane Coumar, Paritosh Shukla, Ajay Kumar Dixit, Jiun-Shyang Leou, John Hsu, Su-Ying Wu, Hsing-Pang Hsieh
Publikováno v:
Nature Precedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0644bac182b2ec08dd90f4265c9ead
https://doi.org/10.1038/npre.2009.2769
https://doi.org/10.1038/npre.2009.2769