Safety and efficacy of oral nemonoxacin versus levofloxacin in treatment of community-acquired pneumonia: A phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority trial

Autor: Jinyi Yuan, Biwen Mo, Zhuang Ma, Yuan Lv, Shih-Lung Cheng, Yanping Yang, Zhaohui Tong, Renguang Wu, Shenghua Sun, Zhaolong Cao, Jufang Wu, Demei Zhu, Liwen Chang, Yingyuan Zhang, Li Zhao, Xiongbiao Wang, Xuefen Wang, Dexi Wang, Xiangyang Li, Yiqiang Peng, Yongjie Liang, Hua Liu, Zuke Xiao, Xiaoju Lv, Shiman Wu, Yuanrong Dai, Yijiang Huang, Zhenghong Hu, Chen Qiu, Xi Li, Suiyang Zhang, Wenpu Li, Shuang Liu, Yi Shi, Chang Xiong, Jiulong Kuang, Qingyu Xiu, Shehuai Cui, Jianguo Li, Qichang Lin, Wenxiang Huang, Yixin Wan, Qimanguli, Ce Shen, Yi Xiao, Xiaoju Wu, Yin Ching Chuang, Wann Cherng Perng, Shih-Ming Tsao, Jeng-Yuan Hsu, Chin-Chou Wang, Jen-Hsien Wang, Pen-Fang Yeh, His-Hsun Lin, P.H. Kuo, Ming-Shian Lin, Wei-Juin Su

Publikováno v: Journal of Microbiology, Immunology and Infection, Vol 52, Iss 1, Pp 35-44 (2019)

Background/Purpose: Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens in community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy

Externí odkaz: https://doaj.org/article/73da3198482c4a74a1820a5effd0ed6d

Benralizumab efficacy and safety in severe asthma: A randomized trial in Asia.

Autor: Lai K; Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Sun D; Inner Mongolia People's Hospital, Hohhot, China., Dai R; Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China., Samoro R; Healthlink Medical-Surgical-Dental Clinics and Diagnostic Center, Iloilo City, Philippines., Park HS; Ajou University School of Medicine, Ajou University Medical Center, Suwon, Republic of Korea., Åstrand A; Late-stage Respiratory & Immunology, AstraZeneca, Gothenburg, Sweden., Cohen D; Late-stage Respiratory & Immunology, AstraZeneca, Gaithersburg, MD, USA., Jison M; Late-stage Respiratory & Immunology, AstraZeneca, Gaithersburg, MD, USA., Shih VH; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA., Werkström V; Late-stage Respiratory & Immunology, AstraZeneca, Gothenburg, Sweden., Yao Y; Respiratory & Immunology, R&D China, AstraZeneca, Shanghai, China., Zhang Y; Respiratory & Immunology, R&D China, AstraZeneca, Shanghai, China., Zheng W; Biometrics, R&D China, AstraZeneca, Shanghai, China., Zhong N; Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: nanshan@vip.163.com., Albert A Jr; Manila Doctors Hospital, Metro Manila, Philippines., Jianping B; Second Hospital of Shanxi Medical University, Shanxi, China., Bi C; The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Lijun C; Yinchuan First People's Hospital, Yinchuan, China., Mei C; Chengdu Fifth People's Hospital, Sichuan, China., Min C; The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Ping C; The General Hospital of Shenyang Military, Shenyang, China., Zhimin C; The Children's Hospital of Zhejiang University College of Medicine, Zhejiang, China., Chih-Feng C; Tri Service General Hospital, Taipei, Taiwan., Sook CY; Asan Medical Center, Seoul, Republic of Korea., Xiuhua F; The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China., Xiwen G; Central Hospital of Minhang District, Shanghai, China., Wei G; Nanjing First Hospital, Nanjing, China., Wei H; Qingdao Municipal Hospital, Qingdao, China., Zhihai H; Navy General Hospital, Beijing, China., Wei HX; The Affiliated Hospital of Guizhou Medical University, Guizhou, China., Kewu H; Beijing Chaoyang Hospital, Beijing, China., Mao H; Jiangsu Province Hospital, Jiangsu, China., Grace Dawn IM; West Visayas State University Medical Center, Iloilo City, Philippines., Inbeom J; Konyang University Hospital, Daejeon, Republic of Korea., Luning J; Affiliated Hospital of Jining Medical College, Jining, China., Mingyan J; Xiangtan Central Hospital, Xiangtan, China., Shanping J; Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China., Meiling J; Zhongshan Hospital of Fudan University, Shangha, China., Jian K; The First Affiliated Hospital of China Medical University, Chongqing, China., Woo KJ; The Catholic University of Korea, Seoul, Republic of Korea., Sang-Ha K; Yonsei University Wonju Severance Christian Hospital, Gangwon-do, Republic of Korea., Jiulong K; The Second Affiliated Hospital of Nanchang University, Nanchang, China., Ping-Hung K; National Taiwan University Hospital, Taipei, Taiwan., Jie L; First Affiliated Hospital of Ganzhou Medical University, Guangzhou, China., Manxiang L; The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Minjing L; The First People's Hospital of Foshan, Foshan, China., Ruoran L; Xuzhou Central Hospital, Jiangsu, China., Wen L; The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China., Xianhua L; The First People's Hospital of Neijiang, Neijiang, China., Yanming L; Beijing Hospital, Beijing, China., Yong LS; Kangbuk Samsung Hospital, Seoul, Republic of Korea., Chuanhe L; Children's Hospital, Capital Institute of Pediatrics, Beijing, China., Chuntao L; West China Hospital, Sichuan University, Sichuan, China., Jing L; The Fifth Affiliated Hospital Sun YAT-SEN University, China., Xiaoxia L; Beijing Friendship Hospital, Beijing, China., Huiyu L; Taizhou People's Hospital, Taizhou, China., Zhuang L; First Affiliated Hospital of Kunming Medical University, Kunming, China., Shengxi M; Xinxiang Central Hospital, Xinxiang, China., Liangping M; Chongqing Three Gorges Central Hospital, Chongqing, China., Hoon MK; Korea University Guro Hospital, Seoul, Republic of Korea., Lin M; Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China., Choon-Sik P; Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea., Sim PH; Ajou University Hospital, Suwon-si, Republic of Korea., Hye-Kyung P; Pusan National University Hospital, Busan, Republic of Korea., Jung-Won P; Severance Hospital, Seoul, Republic of Korea., Diahn-Warng P; Taipei Veterans General Hospital, Taipei, Taiwan., Ronnie S; Healthlink Medical-Surgical-Dental Clinics and Diagnostic Center, Iloilo City, Philippines., Guochao S; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Debin S; Lishui Central Hospital, Lishui, China., Dejun S; Inner Mongolia People's Hospital, Hohhot, China., Chun-Hua W; Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan., Guangfa W; Peking University First Hospital, Beijing, China., Limin W; Hangzhou First People's Hospital, Hangzhou, China., Xuefen W; The First Affiliated Hospital Zhejiang University, Zhejiang, China., Yan W; The Second Affiliated Hospital of Army Medical University, PLA, China., Liping W; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Haihong W; Hainan General Hospital, Haikou, China., Yi X; Yanan Hospital, Kunming City, Yunnan, China., Zuke X; Jiangxi Provincial People's Hospital, Jiangxi, China., Canmao X; The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Jin-Fu X; Shanghai Pulmonary Hospital, Shanghai, China., Xingxiang X; Northern Jiangsu People's Hospital, Jiangsu, China., Xiyuan X; The First Affiliated Hospital of Baotou Medical College, Inner Mongolia, China., Jianping Y; Zhejiang Provincial People's Hospital, Zhejiang, China., Hongzhong Y; Changsha Central Hospital, Changsha, China., Joo YH; Hanyang University Seoul Hospital, Seoul, Republic of Korea., Wencheng Y; The Affiliated Hospital of Qingdao University, Qingdao, China., Jin Z; General Hospital of Ningxia Medical University, Yinchuan, China., Longju Z; The First People's Hospital of Zunyi, Zunyi, China., Min Z; The People's Hospital of Ganzhou, Ganzhou, China., Wei Z; The First Affiliated Hospital of Nanchang University, Nanchang, China., Jianping Z; Tongji Hospital of Huazhong Science and Technology University, Wuhan, China., Ziwen Z; Guangzhou First People's Hospital, Guangzhou, China., Xiaoli Z; Zhongda Hospital Southeast University, Nanjing, China., Yingqun Z; The Third Hospital of Changsha, Changsha, China.

Publikováno v: Respiratory medicine [Respir Med] 2024 Apr 01, pp. 107611. Date of Electronic Publication: 2024 Apr 01.