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Akademický článek

TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC.

Autor: Zhi-Ning Zhao, Jiu-Xu Bai, Qiang Zhou, Bo Yan, Wei-Wei Qin, Lin-Tao Jia, Yan-Ling Meng, Bo-Quan Jin, Li-Bo Yao, Tao Wang, An-Gang Yang

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45133 (2012)

Histone deacetylase (HDAC) inhibitors are emerging as a novel class of anti-tumor agents and have manifested the ability to decrease proliferation and increase apoptosis in different cancer cells. A significant number of genes have been identified as

Externí odkaz: https://doaj.org/article/6c0c4d0b3746482c92a2d45fe3fb3cb1

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Erythropoietin Inhibits Hypoxia–Induced Epithelial-To-Mesenchymal Transition via Upregulation of miR-200b in HK-2 Cells

Autor: Ning Cao, Xiao-ling Zhang, Jiu-xu Bai, Cui Hanmin, Jing-ming Han, Xiao Xiao, Jun-Feng Hao

Publikováno v: Cellular Physiology and Biochemistry, Vol 42, Iss 1, Pp 269-280 (2017)

Background/Aims: Renal tubular epithelial-mesenchymal transition (EMT) is regarded as an important factor leading to renal interstitial fibrosis. Erythropoietin (EPO) has been reported to attenuate renal fibrosis. The mechanism underlying this protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2491e6830bfb836070dd0d1dbfe98089
https://doi.org/10.1159/000477327

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Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5/6 nephrectomy rat model

Autor: Ning Cao, Jun-Feng Hao, Xiao-ling Zhang, Jiu-xu Bai, Cui Hanmin, Jing-ming Han

Publikováno v: BMC Nephrology

Background Endothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal EndoMT in chronic kidney dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cd5ce1c5a1b32b03ef54da64a7132b
https://pubmed.ncbi.nlm.nih.gov/27176224

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Identification of potential biomarkers for clear cell renal cell carcinoma based on microRNA-mRNA pathway relationships

Autor: Jun-Feng Hao, Kai-ming Ren, Bing Shao, Wang Shounan, Cao Ning, Jiu-Xu Bai, Li Xu

Publikováno v: Journal of Cancer Research and Therapeutics, Vol 10, Iss 7, Pp 167-177 (2014)

Background: MicroRNAs (miRNAs) play important roles in tumor genesis. miRNA dysregulation has been widely studied and demonstrated in clear cell renal cell carcinoma (ccRCC). Materials and Methods: We applied a newly proposed method for selecting miR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9171a75819f67cd1a6bcf0c9138cd5d
https://pubmed.ncbi.nlm.nih.gov/25450277

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Tele-ICU: the way forward in geriatric care?

Autor: Jing-ming Han, Jun-Feng Hao, Cui Hanmin, Jiu-xu Bai, Ning Cao, Xiaohua Song

Publikováno v: Aging clinical and experimental research. 26(6)

Aging population is set to increase in the near future, and will need specialized care when admitted to ICUs. The elderly are beset with chronic conditions, such as cardiovascular, COPD, diabetes, renal complications and depression. Specialist opinio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9035553c24f898d98701940a36837d
https://pubmed.ncbi.nlm.nih.gov/24803284

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Tamoxifen represses miR-200 microRNAs and promotes epithelial-to-mesenchymal transition by up-regulating c-Myc in endometrial carcinoma cell lines

Autor: Angang Yang, Bo Yan, Zhining Zhao, Yan-Ling Meng, Tao Wang, Xiao Xiao, Dai-Ming Fan, Jiu-Xu Bai, Weiwei Qin, Lin-Tao Jia, Boquan Jin, Rui Zhang

Publikováno v: Endocrinology. 154(2)

Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5eeca9455af775f850f1ad8f9befe55
https://pubmed.ncbi.nlm.nih.gov/23295740

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TSA Suppresses miR-106b-93-25 Cluster Expression through Downregulation of MYC and Inhibits Proliferation and Induces Apoptosis in Human EMC

Autor: Jiu-Xu Bai, Angang Yang, Libo Yao, Wei-Wei Qin, Yan-Ling Meng, Zhining Zhao, Boquan Jin, Lin-Tao Jia, Qiang Zhou, Bo Yan, Tao Wang

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 9, p e45133 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258befa3fa61910eea3c89139ffd35fc
http://europepmc.org/articles/PMC3446970

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Estrogen-induced dimerization and activation of ERα-fused caspase-8: artificial reversal of the estrogenic hormone effect in carcinogenesis

Autor: Wei Wei Qin, Bo Yan, Zhining Zhao, Yi Li, Jiu-Xu Bai, Lin-Tao Jia, Angang Yang, Tao Wang, Qiang Zhou

Publikováno v: Cancer biologytherapy. 11(9)

The cascade of caspase processing and activation is the core of apoptotic cell signaling. Initiator caspases are activated by adaptor-mediated clustering, which allows the intermolecular autoprocessing of the zymogens in close proximity. Caspase-8, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80a7664cc33e0fcd13e0c3d1e35319c
https://pubmed.ncbi.nlm.nih.gov/21364316

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