Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jitka Špačková"'
Autor:
Klára Gotvaldová, Jitka Špačková, Jiří Novotný, Kamila Baslarová, Petr Ježek, Lenka Rossmeislová, Jan Gojda, Katarína Smolková
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has been associated with the host dysmetabolism of branched-chain amino acids (BCAAs), however, the implications for the role of BCAA metabolism in PDAC development or progression are not cl
Externí odkaz:
https://doaj.org/article/9c8e633d23934de4801d995632b21d73
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Pancreatic-β-cell-specifying transcription factor Nkx6.1, indispensable for embryonic development of the pancreatic epithelium and commitment to β-cell lineage, directly controls the expression of a glucose transporter (Glut2), pyruvate ca
Externí odkaz:
https://doaj.org/article/242b49292f1641c19aed45be9d917bce
Autor:
Katarína Smolková, Jitka Špačková, Klára Gotvaldová, Aleš Dvořák, Alena Křenková, Martin Hubálek, Blanka Holendová, Libor Vítek, Petr Ježek
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Wild type mitochondrial isocitrate dehydrogenase (IDH2) was previously reported to produce oncometabolite 2-hydroxyglutarate (2HG). Besides, mitochondrial deacetylase SIRT3 has been shown to regulate the oxidative function of IDH2. However,
Externí odkaz:
https://doaj.org/article/20506b7cea8046529d75499febad66a9
Biochemical Background in Mitochondria Affects 2HG Production by IDH2 and ADHFE1 in Breast Carcinoma
Autor:
Jitka Špačková, Klára Gotvaldová, Aleš Dvořák, Alexandra Urbančoková, Kateřina Pospíšilová, David Větvička, Alberto Leguina-Ruzzi, Petra Tesařová, Libor Vítek, Petr Ježek, Katarína Smolková
Publikováno v:
Cancers, Vol 13, Iss 7, p 1709 (2021)
Mitochondrial production of 2-hydroxyglutarate (2HG) can be catalyzed by wild-type isocitrate dehydrogenase 2 (IDH2) and alcohol dehydrogenase, iron-containing 1 (ADHFE1). We investigated whether biochemical background and substrate concentration in
Externí odkaz:
https://doaj.org/article/4de32f8c3757401caa147e255ca6976b
Autor:
Jan Ježek, Blanka Holendová, Tomáš Špaček, Lydie Plecitá-Hlavatá, Jan Tauber, Klára Gotvaldová, Vladimír Křen, Lucie Petrásková, Hana Engstová, Andrea Dlasková, Petr Ježek, Katarína Smolková, Jitka Špačková
Publikováno v:
Antioxidants & Redox Signaling
Aims: Glucose-stimulated insulin secretion (GSIS) in pancreatic β cells was expected to enhance mitochondrial superoxide formation. Hence, we elucidated relevant redox equilibria. Results: Unexpectedly, INS-1E cells at transitions from 3 (11 mM; pan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1863:148852
Autor:
Martin Hubálek, Katarína Smolková, Blanka Holendová, Libor Vítek, Alena Křenková, Aleš Dvořák, Klára Gotvaldová, Jitka Špačková, Petr Ježek
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Wild type mitochondrial isocitrate dehydrogenase (IDH2) was previously reported to produce oncometabolite 2-hydroxyglutarate (2HG). Besides, mitochondrial deacetylase SIRT3 has been shown to regulate the oxidative function of IDH2. However, regulatio
Autor:
Lydie Plecitá-Hlavatá, Lukáš Alán, Andrea Dlasková, Jitka Špačková, Vendula Stradalova, Jan Tauber, Petr Ježek, Joerg Bewersdorf, Jan Malínský, Tomáš Špaček, Mark D. Lessard, Hana Engstová, Katarína Smolková
Publikováno v:
The FASEB Journal. 30:1941-1957
The relationship of the inner mitochondrial membrane (IMM) cristae structure and intracristal space (ICS) to oxidative phosphorylation (oxphos) is not well understood. Mitofilin (subunit Mic60) of the mitochondrial contact site and cristae organizing
Autor:
Katarína Smolková, Andrea Dlasková, Jitka Špačková, Anežka Kahancová, Hana Engstová, Martin Bartoš, Petr Ježek, Vojtěch Pavluch, Tomáš Špaček, Lydie Hlavatá
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1859(9)
3D super-resolution microscopy based on the direct stochastic optical reconstruction microscopy (dSTORM) with primary Alexa-Fluor-647-conjugated antibodies is a powerful method for accessing changes of objects that could be normally resolved only by
Autor:
Petr Ježek, Andrea Dlasková, Hana Engstová, Tomáš Špaček, Anežka Kahancová, Vojtěch Pavluch, Katarína Smolková, Jitka Špačková, Lydie Plecitá–Hlavatá
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859:e13