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Akademický článek

Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity assessment

Autor: Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu

Publikováno v: mAbs, Vol 16, Iss 1 (2024)

Precise measurement of the binding activity changes of therapeutic antibodies is important to determine the potential critical quality attributes (CQAs) in developability assessment at the early stage of antibody development. Here, we report a surfac

Externí odkaz: https://doaj.org/article/19cb036bf9994ae38eb022d448f32c83

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Serum IgG N‐glycans enable early detection and early relapse prediction of colorectal cancer

Autor: Yong Gu, Bensong Duan, Jichen Sha, Rongrong Zhang, Jiteng Fan, Xiaoyan Xu, Huijuan Zhao, Xiaoyun Niu, Zhi Geng, Jianxin Gu, Ben Huang, Shifang Ren

Publikováno v: International Journal of Cancer. 152:536-547

Colorectal cancer (CRC) develops mainly from colorectal advanced adenomas (AA), which are considered precancerous lesions. Novel early diagnostic biomarkers are urgently needed to distinguish CRC and AA from healthy control (HC). Alternative glycosyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa166800d9615e969066e660feb33b29
https://doi.org/10.1002/ijc.34298

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Generalized low levels of serum N‐glycans associate with better health status

Autor: Jiteng Fan, Jichen Sha, Shuwai Chang, Huijuan Zhao, Xiaoyun Niu, Yong Gu, Jianxin Gu, Shifang Ren

Publikováno v: Aging Cell.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f087746c7cc030efed488cb6058296a
https://doi.org/10.1111/acel.13855

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The B-Cell-Specific Ablation of B4GALT1 Reduces Cancer Formation and Reverses the Changes in Serum IgG Glycans during the Induction of Mouse Hepatocellular Carcinoma

Autor: Jichen Sha, Rongrong Zhang, Jiteng Fan, Yong Gu, Yiqing Pan, Jing Han, Xiaoyan Xu, Shifang Ren, Jianxin Gu

Publikováno v: Cancers; Volume 14; Issue 5; Pages: 1333

Serum immunoglobulin G (IgG) glycosylation, especially galactosylation, has been found to be related to a variety of tumors, including hepatocellular carcinoma (HCC). However, whether IgG glycan changes occur in the early stages of HCC formation rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267d9f750676eb222dc0bec815bfee66
https://pubmed.ncbi.nlm.nih.gov/35267641

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B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice

Autor: Jichen, Sha, Jiteng, Fan, Rongrong, Zhang, Yong, Gu, Xiaoyan, Xu, Shifang, Ren, Jianxin, Gu

Publikováno v: Journal of Proteomics. 268:104717

IgG N-glycans levels change with advancing age, making it a potential biomarker of aging. β-1,4-galactosyltransferase (B4GALT) gene expression levels also increase with aging. Ultra performance liquid chromatography (UPLC) was used to examine change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be87ffd39a64f13efa4fa4b98b5ad586
https://doi.org/10.1016/j.jprot.2022.104717

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