Widening the Therapeutic Perspectives of Clofazimine by Its Loading in Sulfobutylether β-Cyclodextrin Nanocarriers: Nanomolar IC50 Values against MDR S. epidermidis

Autor: Francesca Bonvicini, Giovanna Gentilomi, Barbara Roda, Valentina Marassi, Éva Fenyvesi, Pierluigi Reschiglian, Ilse Manet, Jitendra Wankar, Gábor Benkovics, Milo Malanga

Publikováno v: Molecular pharmaceutics
15 (2018): 3823–3836. doi:10.1021/acs.molpharmaceut.8b00321
info:cnr-pdr/source/autori:Wankar, Jitendra; Bonvicini, Francesca; Benkovics, Gabor; Marassi, Valentina; Malanga, Milo; Fenyvesi, Eva; Gentilomi, Giovanna Angela; Reschiglian, Pierluigi; Roda, Barbara; Manet, Ilse/titolo:Widening the Therapeutic Perspectives of Clofazimine by Its Loading in Sulfobutylether beta-Cyclodextrin Nanocarriers: Nanomolar IC50 Values against MDR S. epidermidis/doi:10.1021%2Facs.molpharmaceut.8b00321/rivista:Molecular pharmaceutics (Print)/anno:2018/pagina_da:3823/pagina_a:3836/intervallo_pagine:3823–3836/volume:15

Clofazimine (CLZ) is an antibiotic with a promising behavior against Gram-positive bacteria; however, the drug is completely insoluble in water and accumulates in fat tissues. We explored nanocarriers, labeled and not labeled with rhodamine, consisti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789afe8220e2319037f7008513b8ccc3
https://doi.org/10.1021/acs.molpharmaceut.8b00321

Role of Nanomedicine in Management and Prevention of COVID-19

Autor: Jitendra Wankar, Vivek K. Chaturvedi, Raghvendra A. Bohara, Chandrashekhar Bohara, Mohan Singh

Publikováno v: Frontiers in Nanotechnology. 2

COVID-19, or the Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic. At the time of writing this (July 28, 2020), more than 17 million people have become affected and 0.7 million

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ba11cc6f2861703c083852297915a25
https://doi.org/10.3389/fnano.2020.589541

Efficient loading of ethionamide in cyclodextrin-based carriers offers enhanced solubility and inhibition of drug crystallization

Autor: Elisabetta Pancani, Jitendra Wankar, Francesco Manoli, Gábor Benkovics, Éva Fenyvesi, Ruxandra Gref, Ilse Manet, Giuseppina Salzano, Milo Malanga

Publikováno v: International journal of pharmaceutics
531 (2017): 568–576. doi:10.1016/j.ijpharm.2017.05.041
info:cnr-pdr/source/autori:Wankar J.; Salzano G.; Pancani E.; Benkovics G.; Malanga M.; Manoli F.; Gref R.; Fenyvesi E.; Manet I./titolo:Efficient loading of ethionamide in cyclodextrin-based carriers offers enhanced solubility and inhibition of drug crystallization/doi:10.1016%2Fj.ijpharm.2017.05.041/rivista:International journal of pharmaceutics (Print)/anno:2017/pagina_da:568/pagina_a:576/intervallo_pagine:568–576/volume:531

Ethionamide (ETH) is a second line antitubercular drug suffering from poor solubility in water and strong tendency to crystallize. These drawbacks were addressed by loading ETH in β-cyclodextrin (βCyD)-based carriers. The drug was incorporated in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb33bb2dce4ff4b3e613b9992949e709
https://doi.org/10.1016/j.ijpharm.2017.05.041

Rutin nanosuspension for potential management of osteoporosis: effect of particle size reduction on oral bioavailability, in vitro and in vivo activity

Autor: Gera, Sonia, Pooladanda, Venkatesh, Chandraiah Godugu, Veerabhadra Swamy Challa, Jitendra Wankar, Sujatha Dodoala, Sampathi, Sunitha

Clinical significance of Rutin (RUT) is limited by poor dissolution rate and low oral bioavailability. The study was designed to improve the physicochemical and therapeutic potential of the drug by formulating nanosuspension (NS) for osteoporosis. Ru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0597e89cebaa27ac1e7af86296cd6bba

Can mesoporous nanoparticles promote bioavailability of topical pharmaceutics?

Autor: Ilse Manet, Peter Falkman, Johan Engblom, Hanna Thomsen, Sabrina Valetti, Marica B. Ericson, Jitendra Wankar, Adam Feiler

Publikováno v: International journal of pharmaceutics
602 (2021). doi:10.1016/j.ijpharm.2021.120609
info:cnr-pdr/source/autori:Valetti, Sabrina; Thomsen, Hanna; Wankar, Jitendra; Falkman, Peter; Manet, Ilse; Feiler, Adam; Ericson, Marica B.; Engblom, Johan/titolo:Can mesoporous nanoparticles promote bioavailability of topical pharmaceutics?/doi:10.1016%2Fj.ijpharm.2021.120609/rivista:International journal of pharmaceutics (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:602

When applied to skin, particulate matter has been shown to accumulate in hair follicles. In addition to follicles, the skin topography also incorporates trench-like furrows where particles potentially can accumulate; however, the furrows have not bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275d886308f8353d61cca1db65c501e4
https://doi.org/10.1016/j.ijpharm.2021.120609