Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jitendra R. Harjani"'
Autor:
Noel P. Pitcher, Jitendra R. Harjani, Yichao Zhao, Jianwen Jin, Daniel R. Knight, Lucy Li, Papanin Putsathit, Thomas V. Riley, Glen P. Carter, Jonathan B. Baell
Publikováno v:
ACS Omega, Vol 7, Iss 8, Pp 6737-6759 (2022)
Externí odkaz:
https://doaj.org/article/2cb2c9b176f449c28e66dba1e8d0cf30
Autor:
Helena Barker, Amanda De Paoli, Erin Tay, Given Lee, Sandra Duffy, Susan A. Charman, Robert T. Jacobs, Jitendra R. Harjani, Longjin Zhong, Marina Chavchich, Wen Wang, Da Hua Shi, Mitch Mathiew, Stephen Brand, Vicky M. Avery, Michael D. Edstein, Jonathan B. Baell, Darren J. Creek, Daniel L. Priebbenow, David M. Shackleford, Julia G. Beveridge, Karen L. White, Elly Crighton
Publikováno v:
Journal of medicinal chemistry. 64(7)
Novel 3,3'-disubstituted-5,5'-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. To improve the pharmacokinetic properties of the triazine derivatives, a new structure-activity
Autor:
Thuy G. Le, Yaqing Jiao, Robin B. Gasser, Yuezhou Zhang, Yiyue Xie, Silvia C. Teguh, Min Hu, Aya C Taki, Solomon Tadesse, Jitendra R. Harjani, Sarah Preston, Andreas Hofmann, Jose F. Garcia-Bustos, Swapna Varghese, Jonathan B. Baell, Jephthah O. Odiba, Banfeng Ruan, Abdul Jabbar
Publikováno v:
European journal of medicinal chemistry. 190
Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause substantive socioeconomic losses due to the diseases that they cause. The control of nematodes in livestock animals relies heavily on the use of anthelmintic d
Autor:
Jonathan B. Baell, Jitendra R. Harjani, Timothy P. Stinear, Noel P. Pitcher, Yi Nong, Benjamin P Howden, Glen P. Carter, Lucy Li, Deborah A Williamson, Thomas V. Riley
Publikováno v:
Journal of Antimicrobial Chemotherapy. 73:1562-1569
Background: Enterococcus faecium is an important nosocomial pathogen. It has a high propensity for horizontal gene transfer, which has resulted in the emergence of MDR strains that are difficult to treat. The most notorious of these, vancomycin-resis
Autor:
Luigi Aurelio, Sandeep Chhabra, Meghan Hattarki, Matthew L. Dennis, Bim Graham, James D. Swarbrick, Jonathan B. Baell, Ben Cleary, Jeremy Shonberg, Thomas S. Peat, Nicholas Barlow, Michael D. Lee, Zhong-Chang Wang, Noel P. Pitcher, Jitendra R. Harjani, Aaron DeBono, Olan Dolezal, Raphaël Rahmani, Mohamed H. Ahmed
Publikováno v:
Chemistry - A European Journal. 24:1922-1930
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the l
Autor:
Zong-Ming Tang, Da-Hua Shi, Wen-Tao Yang, Chen Lu, Song Xiaokai, Xiao-Dong Ma, Wei-Wei Liu, Meng-Qiu Song, Jitendra R. Harjani, Zhu Huilong, Yu-Wei Liu
Publikováno v:
ChemistrySelect. 2:10572-10579
Autor:
Sandra Duffy, Marina Chavchich, Grennady Wirjanata, Silvia Teguh, Susan A. Charman, Rintis Noviyanti, Jitendra R. Harjani, Leonardo Lucantoni, Lian Xue, Jutta Marfurt, Michael D. Edstein, Ric N. Price, Tamir Dingjan, Stuart A. Ralph, Julia G. Beveridge, Michael A. Walters, Katherine M. Ellis, Scott Blundell, Jonathan B. Baell, Darren J. Creek, Fei Huang, Sabine Fletcher, Sarah Diab, Vicky M. Avery, Jayme L. Dahlin, Francis C. K. Chiu, Kung Ban, Jessica M. Strasser, Matthew E. Cuellar, Da Hua Shi
Publikováno v:
Journal of Medicinal Chemistry. 62(5)
A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, 6k, with an IC50 (50% inhibitory concentration) of 0.008 μM,
Autor:
Martin J. Scanlon, Beow Keat Yap, Raymond S. Norton, Andrew J. Lucke, David K. Chalmers, Jonathan B. Baell, Eleanor W. W. Leung, Sandra E. Nicholson, Philip E. Thompson, Jitendra R. Harjani
Publikováno v:
Journal of Medicinal Chemistry. 59:5799-5809
SPRY domain-containing suppressor of cytokine signaling box protein (SPSB) 2-deficient macrophages have been found to exhibit prolonged expression of inducible nitric oxide synthase (iNOS) and enhanced killing of persistent pathogens, suggesting that
Publikováno v:
Tetrahedron. 72:3256-3261
A new method for the synthesis of cystathionine containing cyclic peptides has been developed. Conventionally such systems are typically made with relatively late-stage on-resin cyclisation involving reaction between a chlorohomoalanine and cysteine
Publikováno v:
European Journal of Organic Chemistry. 2016:2842-2850
In our attempts to synthesize 3-(alkylthio)- and 3-(alkoxy)-1,2,4-triazines without substituents at the 5- or 6-position, the synthesis of their anticipated precursor 3-(methylsulfonyl)-1,2,4 triazine was also optimized. The reactivity of 3-(methylsu