Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jitender Verma"'
Autor:
Chin Fei Chee, Kavitha Nellore, Shatrah Othman, K. Satish Reddy, Yean Kee Lee, Hosahalli Subramanya, Jitender Verma, Noorsaadah Abd Rahman, Iskandar Abdullah, Thomas Antony, Siva Sanjeeva Rao Thunuguntla, Kong Wai Mun
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4669-4680
Poly (ADP-ribose) polymerases (PARPs) play diverse roles in various cellular processes that involve DNA repair and programmed cell death. Amongst these polymerases is PARP-1 which is the key DNA damage-sensing enzyme that acts as an initiator for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3269b1789d32cda0e51c922a508a5b
https://doi.org/10.1016/j.bmc.2015.05.051
https://doi.org/10.1016/j.bmc.2015.05.051
Publikováno v:
Indian Journal of Orthopaedics
Indian Journal of Orthopaedics, Vol 46, Iss 5, Pp 531-535 (2012)
Indian Journal of Orthopaedics, Vol 46, Iss 5, Pp 531-535 (2012)
Background: The diagnosis of knee joint tuberculosis, especially in early stages of synovial disease, has more often been based on clinicoradiological suspicion, with no single test claiming to be a dependable rapid diagnostic test with high sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec579ca53e274fa5fbf51748a9a6ca66
http://europepmc.org/articles/PMC3491786
http://europepmc.org/articles/PMC3491786
Autor:
Raghuvir R. S. Pissurlenkar, Mushtaque S. Shaikh, Vijay M. Khedkar, Premlata K. Ambre, Jitender Verma, Evans C. Coutinho
Publikováno v:
Journal of Molecular Modeling. 16:1251-1268
HIV-1 protease is an obligatory enzyme in the replication process of the HIV virus. The abundance of structural information on HIV-1PR has made the enzyme an attractive target for computer-aided drug design strategies. The daunting ability of the vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67db6bcb7592b1019d3f15e1b7db23f
https://doi.org/10.1007/s00894-009-0636-5
https://doi.org/10.1007/s00894-009-0636-5
Publikováno v:
Current Topics in Medicinal Chemistry. 10:95-115
Quantitative structure-activity relationships (QSAR) have been applied for decades in the development of relationships between physicochemical properties of chemical substances and their biological activities to obtain a reliable statistical model fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a372f3ae1bd6e71266150b5a20c50c8a
https://doi.org/10.2174/156802610790232260
https://doi.org/10.2174/156802610790232260
Local Indices for Similarity Analysis (LISA)—A 3D-QSAR Formalism Based on Local Molecular Similarity
Autor:
Radhakrishnan P. Iyer, Santosh A. Khedkar, Alpeshkumar K. Malde, Jitender Verma, Evans C. Coutinho
Publikováno v:
Journal of Chemical Information and Modeling. 49:2695-2707
A simple quantitative structure activity relationship (QSAR) approach termed local indices for similarity analysis (LISA) has been developed. In this technique, the global molecular similarity is broken up as local similarity at each grid point surro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7334a9921347f82a2a6c7421cfa571
https://doi.org/10.1021/ci900224u
https://doi.org/10.1021/ci900224u
Publikováno v:
Journal of Molecular Modeling. 15:233-245
Since the recognition of HIV-1 integrase as a novel and rational target for HIV therapeutics, remarkable progress has been made in the development of integrase inhibitors. Computational techniques have played a critical role in accelerating research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830eebf89e8178f58ab7d2c22ba3d9b
https://doi.org/10.1007/s00894-008-0399-4
https://doi.org/10.1007/s00894-008-0399-4
Publikováno v:
Molecular informatics. 31(6-7)
A simple and directly applicable 3D-QSAR method, termed Comparative Occupancy Analysis (CoOAn), has been developed. The method is based on the comparison of local occupancies of fragments of an aligned set of molecules in a 3D-grid space. The formali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d10d9b976c00aaed69937212d2a459f
https://pubmed.ncbi.nlm.nih.gov/27477462
https://pubmed.ncbi.nlm.nih.gov/27477462
Publikováno v:
Drug Absorption Studies ISBN: 9780387749006
The blood-brain barrier (BBB) is the single most important factor hindering the development of neurotherapeutics. Experimental methods of BBB permeation determination are cumbersome and expensive; thus, in silico methods for BBB permeation prediction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75ec24b716091d41398e7438efd476f
https://doi.org/10.1007/978-0-387-74901-3_22
https://doi.org/10.1007/978-0-387-74901-3_22
Autor:
Vijay M. Khedkar, Jitender Verma, Arati Prabhu, Alpeshkumar K. Malde, Santosh A. Khedkar, Evans C. Coutinho
Publikováno v:
Journal of computer-aided molecular design. 22(2)
Quantitative Structure-Activity Relationships (QSAR) are being used since decades for prediction of biological activity, lead optimization, classification, identification and explanation of the mechanisms of drug action, and prediction of novel struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba827e0e343c5b7bcde53b520bcfbb1d
https://pubmed.ncbi.nlm.nih.gov/18219446
https://pubmed.ncbi.nlm.nih.gov/18219446
Autor:
Kuldip Upadhyay, Evans C. Coutinho, Hrishikesh Acharya, Vijay Virsodia, Anamik Shah, Atul Manvar, Jitender Verma, Alpeshkumar K. Malde, Arun Mishra
Publikováno v:
European journal of medicinal chemistry. 43(11)
A set of 25 coumarin-4-acetic acid benzylidene hydrazides were synthesized and characterized by NMR, IR and mass spectroscopic techniques. The compounds were evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfa803943ca6f4ddced41b7f5e30ba2
https://pubmed.ncbi.nlm.nih.gov/18328603
https://pubmed.ncbi.nlm.nih.gov/18328603