Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jitender, Mehla"'
Autor:
Pedro D. Manrique, Inga V. Leus, César A. López, Jitender Mehla, Giuliano Malloci, Silvia Gervasoni, Attilio V. Vargiu, Rama K. Kinthada, Liam Herndon, Nicolas W. Hengartner, John K. Walker, Valentin V. Rybenkov, Paolo Ruggerone, Helen I. Zgurskaya, S. Gnanakaran
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The ability Gram-negative pathogens have at adapting and protecting themselves against antibiotics has increasingly become a public health threat. Data-driven models identifying molecular properties that correlate with outer membrane (OM) pe
Externí odkaz:
https://doaj.org/article/45d6aee426a544c597e58b71c5e0adb4
Autor:
Silvia Gervasoni, Jitender Mehla, Charles R. Bergen, Inga V. Leus, Enrico Margiotta, Giuliano Malloci, Andrea Bosin, Attilio V. Vargiu, Olga Lomovskaya, Valentin V. Rybenkov, Paolo Ruggerone, Helen I. Zgurskaya
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Transporters of the resistance-nodulation-cell division (RND) superfamily of proteins are the dominant multidrug efflux power of Gram-negative bacteria. The major RND efflux pump of Pseudomonas aeruginosa is MexAB-OprM, in which the inner me
Externí odkaz:
https://doaj.org/article/09f8ee5600f347ba91948b10681d1d33
Autor:
Jitender Mehla, Giuliano Malloci, Rachael Mansbach, Cesar A. López, Ruslan Tsivkovski, Keith Haynes, Inga V. Leus, Sally B. Grindstaff, Robert H. Cascella, Napoleon D’Cunha, Liam Herndon, Nicolas W. Hengartner, Enrico Margiotta, Alessio Atzori, Attilio V. Vargiu, Pedro D. Manrique, John K. Walker, Olga Lomovskaya, Paolo Ruggerone, S. Gnanakaran, Valentin V. Rybenkov, Helen I. Zgurskaya
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and efflux pumps
Externí odkaz:
https://doaj.org/article/ad1e5b88030c459fa539ac7120f5edba
Autor:
Casey M, Stevens, Svitlana O, Babii, Amitkumar N, Pandya, Wei, Li, Yupeng, Li, Jitender, Mehla, Robyn, Scott, Pooja, Hegde, Pavan K, Prathipati, Atanu, Acharya, Jinchan, Liu, James C, Gumbart, Jeffrey, North, Mary, Jackson, Helen I, Zgurskaya
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(30)
Transporters belonging to the Resistance-Nodulation-cell Division (RND) superfamily of proteins such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9af94afe2d55ff44c95044b95c1fc0f
https://pubmed.ncbi.nlm.nih.gov/35939679
https://pubmed.ncbi.nlm.nih.gov/35939679
Autor:
Casey M. Stevens, Svitlana O. Babii, Amitkumar N. Pandya, Wei Li, Yupeng Li, Jitender Mehla, Robyn Scott, Pooja Hegde, Pavan K. Prathipati, Atanu Acharya, Jinchan Liu, James C. Gumbart, Jeffrey North, Mary Jackson, Helen I. Zgurskaya
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Transporters belonging to the Resistance-Nodulation-cell Division (RND) superfamily of proteins such as Mycobacterium tuberculosis MmpL3 and its analogs are the focus of intense investigations due to their importance in the physiology of Corynebacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae53713c9b504d24cabff20e540cd2a5
https://doi.org/10.1073/pnas.2113963119
https://doi.org/10.1073/pnas.2113963119
Autor:
Vincent Bonifay, Shibin Zhao, Helen I. Zgurskaya, Jitender Mehla, Justyna W. Adamiak, Derek S. Tan
Publikováno v:
Nat Chem Biol
We live in the era of antibiotic resistance, and this problem will progressively worsen if no new solutions emerge. In particular, Gram-negative pathogens present both biological and chemical challenges that hinder the discovery of new antibacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da71679955acbb81263f47257018522c
https://doi.org/10.1038/s41589-020-00674-6
https://doi.org/10.1038/s41589-020-00674-6
Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-Negative Bacteria
Autor:
John K. Walker, Valentin V. Rybenkov, Nicolas W. Hengartner, Sandrasegaram Gnanakaran, Jitender Mehla, Inga V. Leus, Rachael A. Mansbach, Helen I. Zgurskaya, Cesar A. Lopez
Publikováno v:
J Chem Inf Model
Drug discovery faces a crisis. The industry has used up the “obvious” space in which to find novel drugs for biomedical applications, and productivity is declining. One strategy to combat this is rational approaches to expand the search space wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3f6424e982597ca7e8ff7aeac1e887
https://doi.org/10.1021/acs.jcim.0c00352
https://doi.org/10.1021/acs.jcim.0c00352
Autor:
Valentin V. Rybenkov, Olga Lomovskaya, Sandrasegaram Gnanakaran, Robert H. Cascella, Ruslan Tsivkovski, Cesar A. Lopez, Giuliano Malloci, Helen I. Zgurskaya, Nicolas W. Hengartner, Enrico Margiotta, Rachael A. Mansbach, Napoleon D’Cunha, Alessio Atzori, Sally B. Grindstaff, Paolo Ruggerone, Inga V. Leus, Liam Herndon, Pedro D. Manrique, Jitender Mehla, Attilio Vittorio Vargiu, John K. Walker, Keith M. Haynes
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
mBio
mBio
Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and efflux pumps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e70ac41699c55d5e6772078eb1d0d24
https://journals.asm.org/doi/10.1128/mBio.02785-20
https://journals.asm.org/doi/10.1128/mBio.02785-20
Autor:
Mary Brockett, J. Harry Caufield, Gaetano T. Montelione, Peter Uetz, George W. Liechti, Ali Hosseinnia, Tanneke den Blaauwen, Sadhna Phanse, Neha Sakhawalkar, Sergey M. Vorobiev, Alla Gagarinova, Randy M. Morgenstein, Jitender Mehla, John F. Hunt, Rong Xiao, Mohan Babu
YhcB, an uncharacterized protein conserved across gamma-proteobacteria, is composed predominantly of a single Domain of Unknown Function (DUF 1043) with an N-terminal transmembrane α-helix. Here, we show that E. coli YhcB is a conditionally essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e9c842e751ee6e7f00eb437b8be0c18
https://doi.org/10.1101/2020.12.31.425005
https://doi.org/10.1101/2020.12.31.425005
Autor:
Jitender Mehla, J. Harry Caufield, Jeroen Wagemans, Allison Johnson, Rebekah M. Dedrick, Peter Uetz, Graham F. Hatfull, Neha Sakhawalkar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Mycobacteriophage are viruses that infect mycobacteria. More than 1,400 mycobacteriophage genomes have been sequenced, coding for over one hundred thousand proteins of unknown functions. Here we investigate mycobacteriophage Giles-host protein-protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb2897a5aba89e8442ec9f3970c8b2a
http://link.springer.com/article/10.1038/s41598-017-16303-7
http://link.springer.com/article/10.1038/s41598-017-16303-7