Výsledky vyhledávání - "Jishnu K. S. Krishnan"

Akademický článek

Isoflurane-lipid emulsion injection as an anticonvulsant and neuroprotectant treatment for nerve agent exposure

Autor: Jishnu K. S. Krishnan, John R. Moffett, Narayanan Puthillathu, Erik A. Johnson, Aryan M. Namboodiri

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

We have shown that briefly inhaled isoflurane rapidly halts convulsions and protects the central nervous system (CNS) from organophosphate-induced neuronal loss when administered at 5% for 5 min, even as late as 1 h after organophosphate exposure. In

Externí odkaz: https://doaj.org/article/098b19a13bb943d995d423f75d976f02

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Akademický článek

Brief isoflurane administration as an adjunct treatment to control organophosphate-induced convulsions and neuropathology

Autor: Narayanan Puthillathu, John R. Moffett, Alexandru Korotcov, Asamoah Bosomtwi, Ranjini Vengilote, Jishnu K. S. Krishnan, Erik A. Johnson, Peethambaran Arun, Aryan M. Namboodiri

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Organophosphate-based chemical agents (OP), including nerve agents and certain pesticides such as paraoxon, are potent acetylcholinesterase inhibitors that cause severe convulsions and seizures, leading to permanent central nervous system (CNS) damag

Externí odkaz: https://doaj.org/article/81330480203f4bd7bdbf175537380d88

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Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation

Autor: Narayanan Puthillathu Vasudevan, Dharmendra K. Soni, John R. Moffett, Jishnu K. S. Krishnan, Abhilash P. Appu, Sarani Ghoshal, Peethambaran Arun, John M. Denu, Thomas P. Flagg, Roopa Biswas, Aryan M. Namboodiri

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3673

The coordination of cellular biological processes is regulated in part via metabolic enzymes acting to match cellular metabolism to current conditions. The acetate activating enzyme, acyl-coenzyme A synthetase short-chain family member 2 (Acss2), has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca847e0aa70671ab5fb4d4e55f69c0a

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Akademický článek

Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease

Autor: Abhilash P. Appu, John R. Moffett, Peethambaran Arun, Sean Moran, Vikram Nambiar, Jishnu K. S. Krishnan, Narayanan Puthillathu, Aryan M. A. Namboodiri

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise involvement of elevated NAA in the pathogenesis of Canavan disease is an ongoing debate. In the pre

Externí odkaz: https://doaj.org/article/e1631f1ff95845ab838fe1462d225129

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