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Akademický článek

Isoflurane-lipid emulsion injection as an anticonvulsant and neuroprotectant treatment for nerve agent exposure

Autor: Jishnu K. S. Krishnan, John R. Moffett, Narayanan Puthillathu, Erik A. Johnson, Aryan M. Namboodiri

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

We have shown that briefly inhaled isoflurane rapidly halts convulsions and protects the central nervous system (CNS) from organophosphate-induced neuronal loss when administered at 5% for 5 min, even as late as 1 h after organophosphate exposure. In

Externí odkaz: https://doaj.org/article/098b19a13bb943d995d423f75d976f02

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Electron Attachment to Wobble Base Pairs

Autor: J, Jishnu Narayanan S, Bachhar, Arnab, Tripathi, Divya, Dutta, Achintya Kumar

We have analyzed the low-energy electron attachment to wobble base pairs using the equation motion coupled cluster method and extended basis sets. A doorway mechanism exists for the attachment of the additional electron to the base pairs, where the i

Externí odkaz: http://arxiv.org/abs/2210.07965

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A Doorway mechanism for Electron Attachment Induced DNA Strand Break

Autor: J, Jishnu Narayanan S, Tripathi, Divya, Dutta, Achintya Kumar

We report a new doorway mechanism for the dissociative electron attachment to genetic materials. The dipole-bound state of the nucleotide anion acts as the doorway for electron capture in the genetic material. The electron gets subsequently transferr

Externí odkaz: http://arxiv.org/abs/2106.10518

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Akademický článek

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Akademický článek

Brief isoflurane administration as an adjunct treatment to control organophosphate-induced convulsions and neuropathology

Autor: Narayanan Puthillathu, John R. Moffett, Alexandru Korotcov, Asamoah Bosomtwi, Ranjini Vengilote, Jishnu K. S. Krishnan, Erik A. Johnson, Peethambaran Arun, Aryan M. Namboodiri

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Organophosphate-based chemical agents (OP), including nerve agents and certain pesticides such as paraoxon, are potent acetylcholinesterase inhibitors that cause severe convulsions and seizures, leading to permanent central nervous system (CNS) damag

Externí odkaz: https://doaj.org/article/81330480203f4bd7bdbf175537380d88

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