Intra-tumoral administration of CHST15 siRNA remodels tumor microenvironment and augments tumor-infiltrating T cells in pancreatic cancer

Autor: Juanjuan Ye, Futoshi Suizu, Keiko Yamakawa, Yuri Mukai, Hiroyuki Yoneyama, Jiro Kondo, Motohiko Kato, Akira Nishiyama, Naohisa Yahagi, Kyuichi Kadota

Publikováno v: Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200812- (2024)

The dense stroma is one cause of poor efficacy of T cell-mediated immunotherapy in pancreatic ductal adenocarcinoma (PDAC). Carbohydrate sulfotransferase 15 (CHST15) is a proteoglycan-synthetic enzyme responsible for remodeling tumor stroma. Intra-tu

Externí odkaz: https://doaj.org/article/f3913de0323e46ddb401ad4843348eff

Structural Bases for the Fitness Cost of the Antibiotic-Resistance and Lethal Mutations at Position 1408 of 16S rRNA

Autor: Jiro Kondo, Mai Koganei

Publikováno v: Molecules, Vol 25, Iss 1, p 159 (2019)

To understand a structural basis for the fitness cost of the A1408G antibiotic-resistance mutation in the ribosomal A-site RNA, we have determined crystal structures of its A1408C and A1408U lethal mutants, and made comparison with previously solved

Externí odkaz: https://doaj.org/article/36a1610d1fe24761a1b4038635612771

BasePairPuzzle: Molecular Models for Manipulating the Concept of Hydrogen Bonds and Base Pairs in Nucleic Acids

Autor: Jiro Kondo, Shota Nakamura

Publikováno v: Journal of Chemical Education. 100:946-954

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdcf356cce3af5077652d1d000b6c7d6
https://doi.org/10.1021/acs.jchemed.2c00964

Constipation Is a Frequent Problem Associated with Vascular Complications in Patients with Type 2 Diabetes: A Cross-sectional Study

Autor: Hiroyuki, Ito, Kiyoko, Ito, Mahika, Tanaka, Mayumi, Hokamura, Mari, Tanaka, Eiji, Kusano, Jiro, Kondo, Takuma, Izutsu, Suzuko, Matsumoto, Hideyuki, Inoue, Shinichi, Antoku, Tomoko, Yamasaki, Toshiko, Mori, Michiko, Togane

Publikováno v: Internal Medicine. 61:1309-1317

Objective Diabetes is recognized as an underlying disease of constipation. However, the prevalence of constipation varies according to the diagnostic criteria applied. We investigated the prevalence of constipation based on the new guideline for cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1642472026a8e09af99ec3319f0401
https://doi.org/10.2169/internalmedicine.7676-21

Chloride ligands on DNA-stabilized silver nanoclusters

Autor: Anna Gonzàlez-Rosell, Sami Malola, Rweetuparna Guha, Nery R. Arevalos, María Francisca Matus, Meghen E. Goulet, Esa Haapaniemi, Benjamin B. Katz, Tom Vosch, Jiro Kondo, Hannu Häkkinen, Stacy M. Copp

Publikováno v: Gonzàlez-Rosell, A, Malola, S, Guha, R, Arevalos, N R, Matus, M F, Goulet, M E, Haapaniemi, E, Katz, B B, Vosch, T, Kondo, J, Häkkinen, H & Copp, S M 2023, ' Chloride Ligands on DNA-Stabilized Silver Nanoclusters ', Journal of the American Chemical Society, vol. 145, no. 19, pp. 10721−10729 . https://doi.org/10.1021/jacs.3c01366
Journal of the American Chemical Society, vol 145, iss 19

DNA-stabilized silver nanoclusters (AgN-DNAs) are known to have one or two DNA oligomer ligands per nanocluster. Here, we present the first evidence that AgN-DNA species can possess additional chloride ligands that lead to increased stability in biol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bf2760a6b84cad1514485670a2414e
https://doi.org/10.26434/chemrxiv-2023-m9txt