Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jiri Masin"'
Autor:
Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo, Jiri Masin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the acylated segment of the RTX adenylate cyclas
Externí odkaz:
https://doaj.org/article/6f873568b2e4490a9da5948d8fb80b36
Autor:
Adriana Osickova, Nataliya Balashova, Jiri Masin, Miroslav Sulc, Jana Roderova, Tomas Wald, Angela C. Brown, Evan Koufos, En Hyung Chang, Alexander Giannakakis, Edward T. Lally, Radim Osicka
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-15 (2018)
Abstract Kingella kingae is a member of the commensal oropharyngeal flora of young children. Improvements in detection methods have led to the recognition of K. kingae as an emerging pathogen that frequently causes osteoarticular infections in childr
Externí odkaz:
https://doaj.org/article/0ad24cd2bb474f8e83870cb95223ed73
Autor:
Jana Holubova, Attila Juhasz, Jiri Masin, Ondrej Stanek, David Jurnecka, Adriana Osickova, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11655 (2021)
The whooping cough agent, Bordetella pertussis, secretes an adenylate cyclase toxin–hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal activities of hos
Externí odkaz:
https://doaj.org/article/0803fecdd7814728ba5514a977f1ed41
Publikováno v:
Toxins, Vol 11, Iss 6, p 336 (2019)
Cytolytic leukotoxins of the repeat in toxin (RTX) family are large proteins excreted by gram-negative bacterial pathogens through the type 1 secretion system (T1SS). Due to low yields and poor stability in cultures of the original pathogens, it is u
Externí odkaz:
https://doaj.org/article/1dc05b4503764fa582bcba2113948f1d
Publikováno v:
Toxins, Vol 10, Iss 6, p 245 (2018)
The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis. The toxin penetrates target cell membranes and exhibits three distinct b
Externí odkaz:
https://doaj.org/article/fd1fbc95a09946588edf506840724f29
Autor:
Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka
Publikováno v:
Toxins, Vol 9, Iss 10, p 300 (2017)
Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin–hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated acti
Externí odkaz:
https://doaj.org/article/c6ee91ce9982438d94d1b3ecb891ef0a
Autor:
Irena Adkins, Jana Kamanova, Aneta Kocourkova, Martina Svedova, Jakub Tomala, Hana Janova, Jiri Masin, Barbora Chladkova, Ladislav Bumba, Marek Kovar, Padraig J Ross, Ludmila Tuckova, Radek Spisek, Kingston H G Mills, Peter Sebo
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104064 (2014)
Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that subverts cellular signaling
Externí odkaz:
https://doaj.org/article/4e60af0e4ce6475bbe8900143a0c5749
Autor:
Radovan Fiser, Jiri Masin, Ladislav Bumba, Eva Pospisilova, Catherine Fayolle, Marek Basler, Lenka Sadilkova, Irena Adkins, Jana Kamanova, Jan Cerny, Ivo Konopasek, Radim Osicka, Claude Leclerc, Peter Sebo
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002580 (2012)
Bordetella adenylate cyclase toxin-hemolysin (CyaA) penetrates the cytoplasmic membrane of phagocytes and employs two distinct conformers to exert its multiple activities. One conformer forms cation-selective pores that permeabilize phagocyte membran
Externí odkaz:
https://doaj.org/article/61bbaf2f46a14d88aeb943ef33d85b35
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000901 (2010)
Bordetella adenylate cyclase toxin (CyaA) binds the alpha(M)beta(2) integrin (CD11b/CD18, Mac-1, or CR3) of myeloid phagocytes and delivers into their cytosol an adenylate cyclase (AC) enzyme that converts ATP into the key signaling molecule cAMP. We
Externí odkaz:
https://doaj.org/article/61e2561695af418790e7c6f6a82db51e
Autor:
Nela Klimova, Humaira Khaliq, Peter Sebo, David Jurnecka, Adriana Osickova, Jiri Masin, Radim Osicka
Publikováno v:
J Biol Chem
The Bordetella adenylate cyclase toxin-hemolysin (CyaA) and the α-hemolysin (HlyA) of Escherichia coli belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins. HlyA preferentially binds the α(L)β(2) integrin LFA-1 (CD11a/C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530c7aa2f5b82f4b74cc9c16010fb520
https://doi.org/10.1074/jbc.ra120.013630
https://doi.org/10.1074/jbc.ra120.013630