Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jiri Hejnar"'
Autor:
Filip Senigl, Yaakov Maman, Ravi K. Dinesh, Jukka Alinikula, Rashu B. Seth, Lubomira Pecnova, Arina D. Omer, Suhas S.P. Rao, David Weisz, Jean-Marie Buerstedde, Erez Lieberman Aiden, Rafael Casellas, Jiri Hejnar, David G. Schatz
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3902-3915.e8 (2019)
Summary: Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible
Externí odkaz:
https://doaj.org/article/2f5ff53bf6664a26b0aa7baa83fb62a9
Autor:
Besma Aouar, Denisa Kovarova, Sebastien Letard, Albert Font-Haro, Jonathan Florentin, Jan Weber, David Durantel, Laurence Chaperot, Joel Plumas, Katerina Trejbalova, Jiri Hejnar, Jacques A Nunès, Daniel Olive, Patrice Dubreuil, Ivan Hirsch, Ruzena Stranska
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156063 (2016)
Crosslinking of regulatory immunoreceptors (RR), such as BDCA-2 (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses production of type-I interferon (IFN)-α/β and other cytokines in response to Toll-like receptor (
Externí odkaz:
https://doaj.org/article/31bcf670f149405b9ee89d6a63e165cf
Autor:
Antonio R L Teixeira, Clever Gomes, Nadjar Nitz, Alessandro O Sousa, Rozeneide M Alves, Maria C Guimaro, Ciro Cordeiro, Francisco M Bernal, Ana C Rosa, Jiri Hejnar, Eduardo Leonardecz, Mariana M Hecht
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e1000 (2011)
BackgroundThe administration of anti-trypanosome nitroderivatives curtails Trypanosoma cruzi infection in Chagas disease patients, but does not prevent destructive lesions in the heart. This observation suggests that an effective treatment for the di
Externí odkaz:
https://doaj.org/article/e77f8743521043178c263dfa06d9d255
Autor:
Jana Blazkova, Katerina Trejbalova, Françoise Gondois-Rey, Philippe Halfon, Patrick Philibert, Allan Guiguen, Eric Verdin, Daniel Olive, Carine Van Lint, Jiri Hejnar, Ivan Hirsch
Publikováno v:
PLoS Pathogens, Vol 5, Iss 8, p e1000554 (2009)
DNA methylation of retroviral promoters and enhancers localized in the provirus 5' long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that allows retroviruses to evade host immune responses and antiretroviral dr
Externí odkaz:
https://doaj.org/article/307694fc57d043948033a9ae08853063
Autor:
Magda Matoušková, Jiří Plachý, Dana Kučerová, Ľubomíra Pecnová, Markéta Reinišová, Josef Geryk, Vít Karafiát, Tomáš Hron, Jiří Hejnar
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012468 (2024)
Genetic editing of the germline using CRISPR/Cas9 technology has made it possible to alter livestock traits, including the creation of resistance to viral diseases. However, virus adaptability could present a major obstacle in this effort. Recently,
Externí odkaz:
https://doaj.org/article/67999101ee64415f8be86a564cc413ce
Autor:
Krystof Stafl, Martin Travnicek, Dana Kucerova, Lubomira Pecnova, Veronika Krchlikova, Eliska Galikova, Jiri Hejnar, Katerina Trejbalova
BackgroundHuman Syncytin-1 is an envelope glycoprotein of retroviral origin. After interaction with ASCT2, its cellular receptor, Syncytin-1 triggers cell-cell fusion and formation of a multinuclear syncytiotrophoblast layer of the placenta. The ASCT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1752a9e74689b07fe391269133c9eb7a
https://doi.org/10.21203/rs.3.rs-227071/v1
https://doi.org/10.21203/rs.3.rs-227071/v1
Autor:
David G. Schatz, Jean-Marie Buerstedde, Suhas S.P. Rao, Jukka Alinikula, Filip Šenigl, Yaakov Maman, Ravi K. Dinesh, Lubomira Pecnova, David Weisz, Jiri Hejnar, Rafael Casellas, Rashu B. Seth, Arina D. Omer, Erez Lieberman Aiden
Publikováno v:
Cell reports
Cell Reports, Vol 29, Iss 12, Pp 3902-3915.e8 (2019)
Cell Reports, Vol 29, Iss 12, Pp 3902-3915.e8 (2019)
SUMMARY Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible
Autor:
Laurence Chaperot, Joel Plumas, Ruzena Wiersum Stranska, Jacques A. Nunès, Daniel Olive, Jonathan Florentin, Jiri Hejnar, Sébastien Letard, Patrice Dubreuil, Besma Aouar, Jan Weber, Katerina Trejbalova, Denisa Kovarova, Ivan Hirsch, Albert Font-Haro, David Durantel
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0156063. ⟨10.1371/journal.pone.0156063⟩
PLoS ONE, 2016, 11 (6), pp.e0156063. ⟨10.1371/journal.pone.0156063⟩
PLoS ONE, Vol 11, Iss 6, p e0156063 (2016)
PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0156063. ⟨10.1371/journal.pone.0156063⟩
PLoS ONE, 2016, 11 (6), pp.e0156063. ⟨10.1371/journal.pone.0156063⟩
PLoS ONE, Vol 11, Iss 6, p e0156063 (2016)
International audience; Crosslinking of regulatory immunoreceptors (RR), such as BDCA-2 (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses production of type-I interferon (IFN)-α/β and other cytokines in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45e8250982a8db881a3a64fc54b4518
https://www.hal.inserm.fr/inserm-01357267/document
https://www.hal.inserm.fr/inserm-01357267/document
Publikováno v:
BMC Veterinary Research, Vol 18, Iss 1, Pp 1-9 (2022)
Abstract Background Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longe
Externí odkaz:
https://doaj.org/article/b1efbb7711f7492f8f38e545135340e2
Publikováno v:
Journal of Virology. 84:4204-4211
Retroviruses and retrovirus-derived vectors integrate nonrandomly into the genomes of host cells with specific preferences for transcribed genes, gene-rich regions, and CpG islands. However, the genomic features that influence the transcriptional act