Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Jiri Gut"'
Autor:
Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Md Mahmudul Hasan, Peter Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiri Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite de
Externí odkaz:
https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7
Autor:
Yonathan de Jesus Parra, Rosa Elena Ferrer, Julia Bruno-Colmenarez, Jaime Charris, Gricela Lobo, Neira Gamboa de Domínguez, Philip J. Rosenthal, Jiri Gut
Publikováno v:
Orbital: The Electronic Journal of Chemistry, Vol 9, Iss 4, Pp 308-314 (2017)
A simple synthesis and study by UV-vis, IR, NMR, ESI-CID-MS2 and X-ray diffraction of ((2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl}ethylidene)hydrazinecarbothioamide is reported. It was tested in vitro against chloroquine-resistant strain (W2)
Externí odkaz:
https://doaj.org/article/6c062354ade9479ea7227361d43c7a05
Autor:
Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, Philip J. Rosenthal
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Benzoxaboroles have been shown to be active against different pathogens. Here, the authors show that the benzoxaborole AN3661 inhibitsPlasmodium falciparum in vitroand in mouse models, and identify a homologue of a mammalian cleavage and polyadenylat
Externí odkaz:
https://doaj.org/article/0a61f14362894ce98b395b6ccf63a199
Autor:
Chelsea Fischer, Iosune Ibiricu Urriza, Christina A Bulman, K C Lim, Jiri Gut, Sophie Lachau-Durand, Marc Engelen, Ludo Quirynen, Fetene Tekle, Benny Baeten, Brenda Beerntsen, Sara Lustigman, Judy Sakanari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0006787 (2019)
River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are re
Externí odkaz:
https://doaj.org/article/242d359b1ba14723bac1cecbb901a1d9
Autor:
Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust, Adam R. Renslo
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 15-25 (2013)
Inhibition of the Trypanosoma cruzi cysteine protease cruzain has been proposed as a therapeutic approach for the treatment of Chagas’ disease. Among the best-studied cruzain inhibitors to date is the vinylsulfone K777 (1), which has proven effecti
Externí odkaz:
https://doaj.org/article/e62bfad262f447a899c4489a4219fb1f
Autor:
Christoph Gelhaus, Matthias Leippe, Tanja Schirmeister, Philip J. Rosenthal, Jiri Gut, Gabriele Pradel, Saskia Heppner, Birgit Vedder, Franziska Schulz, Markus Schiller, Monika Herb, Ulrich Kaeppler, Marie-Adrienne Dude
Publikováno v:
Molecules, Vol 14, Iss 1, Pp 19-35 (2008)
A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series d
Externí odkaz:
https://doaj.org/article/4565cec2b0ab47c490c6d71ee08fe49e
Autor:
Bathelemy Ngameni, Jean Watchueng, Fabrice Fekam Boyom, Felix Keumedjio, Bonaventure T. Ngadjui, Jiri Gut, B.M. Abegaz, Philip J. Rosenthal
Publikováno v:
ARKIVOC, Vol 2007, Iss 13, Pp 116-123 (2007)
Externí odkaz:
https://doaj.org/article/71f57ac8f3484a07a8b1100568c7bd6f
Autor:
Christina A Bulman, Chelsea M Bidlow, Sara Lustigman, Fidelis Cho-Ngwa, David Williams, Alberto A Rascón, Nancy Tricoche, Moses Samje, Aaron Bell, Brian Suzuki, K C Lim, Nonglak Supakorndej, Prasit Supakorndej, Alan R Wolfe, Giselle M Knudsen, Steven Chen, Chris Wilson, Kean-Hooi Ang, Michelle Arkin, Jiri Gut, Chris Franklin, Chris Marcellino, James H McKerrow, Anjan Debnath, Judy A Sakanari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003534 (2015)
Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC), and albendazole are used in control programs for
Externí odkaz:
https://doaj.org/article/1872fa3e64e84c4c88486f9960a5d481
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 1, p e1494 (2012)
Lymphatic filariasis is caused by filarial nematode parasites, including Brugia malayi. Adult worms live in the lymphatic system and cause a strong immune reaction that leads to the obstruction of lymph vessels and swelling of the extremities. Chroni
Externí odkaz:
https://doaj.org/article/ebd960d316c44dc49e4f387c4bc1a225
Autor:
Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1736 (2012)
BACKGROUND:Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due
Externí odkaz:
https://doaj.org/article/0fedffa603054e8faa798a38e8ca4f82