Zobrazeno 1 - 10
of 466
pro vyhledávání: '"Jiri Mestecky"'
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Secretory (S) IgA antibodies against severe acute respiratory syndrome (SARS)-CoV-2 are induced in saliva and upper respiratory tract (URT) secretions by natural infection and may be critical in determining the outcome of initial infection.
Externí odkaz:
https://doaj.org/article/02c388e98eaf4c87b91edcca962902f1
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IgA nephropathy (IgAN) is an autoimmune disease in which poorly galactosylated IgA1 is the antigen recognized by naturally occurring anti-glycan antibodies, leading to formation of nephritogenic circulating immune complexes. Incidence of IgAN display
Externí odkaz:
https://doaj.org/article/bb7e6d959cc84ddbb8726035db2e82cc
Autor:
Michael W. Russell, Jiri Mestecky
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact with the immune system, likely through the nasal passages and Waldeyer
Externí odkaz:
https://doaj.org/article/b67936c14ca543ca82dd80189ae60bba
Autor:
Jiri Mestecky
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 2 (2022)
Extensive experiments performed mostly in a variety of animal models convincingly demonstrated the protective effect of polyclonal or monoclonal antibodies administered by the mucosal route. Because of the independence of the mucosal and systemic com
Externí odkaz:
https://doaj.org/article/33e896e96aea4379be915b128ed7c84f
Autor:
Katerina Zachova, Petr Kosztyu, Josef Zadrazil, Karel Matousovic, Karel Vondrak, Petr Hubacek, Klara Kostovcikova, Helena Tlaskalova Hogenova, Jiri Mestecky, Milan Raska
Publikováno v:
Biomedical Papers, Vol 164, Iss 3, Pp 247-254 (2020)
Aims: Epstein-Barr virus (EBV) targets predominantly B cells and these cells could acquire new phenotype characteristics. Here we analyzed whether EBV-infected and -uninfected B cells from healthy subjects differ in proportion of dominant phenotypes,
Externí odkaz:
https://doaj.org/article/c79a8d1ab0aa4c6e86eb7fbfa9d9721e
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The mucosal immune system is the largest component of the entire immune system, having evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS-CoV-2 initially infects the upper respiratory tract, its first interacti
Externí odkaz:
https://doaj.org/article/d3059528b49d453fa36c63cc3e4a1d3c
Autor:
Katerina Zachova, Petr Kosztyu, Josef Zadrazil, Karel Matousovic, Karel Vondrak, Petr Hubacek, Bruce A. Julian, Zina Moldoveanu, Zdenek Novak, Klara Kostovcikova, Milan Raska, Jiri Mestecky
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African Americans. Polymeric IgA1 with galactose-deficient hinge-region glycans is recognized as auto-
Externí odkaz:
https://doaj.org/article/beb2f4e99f604688887524e5bc2314c4
Autor:
Petr Kosztyu, Martin Hill, Jana Jemelkova, Lydie Czernekova, Leona Raskova Kafkova, Miroslav Hruby, Karel Matousovic, Karel Vondrak, Josef Zadrazil, Ivan Sterzl, Jiri Mestecky, Milan Raska
Publikováno v:
Kidney & Blood Pressure Research, Vol 43, Iss 2, Pp 350-359 (2018)
Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomer
Externí odkaz:
https://doaj.org/article/57f47fc2fc59432991c238c9c39f9f3b
Autor:
David C. Moylan, Paul A. Goepfert, Mirjam-Colette Kempf, Michael S. Saag, Holly E. Richter, Jiri Mestecky, Steffanie Sabbaj
Publikováno v:
Pathogens and Immunity, Vol 1, Iss 2, Pp 371-389 (2017)
Background:Tissue resident memory T cells (TrM) provide an enhanced response against infection at mucosal surfaces, yet their function has not been extensively studied in humans, including the female genital tract (FGT). Methods: Using polychromatic
Externí odkaz:
https://doaj.org/article/1380b56cadd54ea185106b344ec7bcd8
Autor:
Jiri Mestecky, Michael E. Lamm, Pearay L. Ogra, Warren Strober, John Bienenstock, Jerry R. McGhee, Lloyd Mayer
Mucosal immunology is so important since most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes. Mucosal Immunology, now in its third edition, is the only comprehens
