Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Jiri, Suttnar"'
1
Akademický článek
Imatinib therapy of chronic myeloid leukemia significantly reduces carnitine cell intake, resulting in adverse events
Autor: Pavel Burda, Alzbeta Hlavackova, Vendula Polivkova, Nikola Curik, Adam Laznicka, Jitka Krizkova, Jiri Suttnar, Pavel Klener, Katerina Machova Polakova
Publikováno v: Molecular Metabolism, Vol 88, Iss , Pp 102016- (2024)
Objective: A prominent, safe and efficient therapy for patients with chronic myeloid leukemia (CML) is inhibiting oncogenic protein BCR::ABL1 in a targeted manner with imatinib, a tyrosine kinase inhibitor. A substantial part of patients treated with
Externí odkaz: https://doaj.org/article/5291343c15e94e9fb1424c43740d28fb
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2
Akademický článek
Fibrin Clot Formation under Oxidative Stress Conditions
Autor: Jirina Kaufmanova, Jana Stikarova, Alzbeta Hlavackova, Leona Chrastinova, Martin Maly, Jiri Suttnar, Jan Evangelista Dyr
Publikováno v: Antioxidants, Vol 10, Iss 6, p 923 (2021)
During coagulation, the soluble fibrinogen is converted into insoluble fibrin. Fibrinogen is a multifunctional plasma protein, which is essential for hemostasis. Various oxidative posttranslational modifications influence fibrinogen structure as well
Externí odkaz: https://doaj.org/article/f2fe94ed175a4b309c2abdd591a4a159
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3
Akademický článek
Molecular Dynamic Simulations Suggest That Metabolite-Induced Post-Translational Modifications Alter the Behavior of the Fibrinogen Coiled-Coil Domain
Autor: Zofie Sovova, Jiri Suttnar, Jan E. Dyr
Publikováno v: Metabolites, Vol 11, Iss 5, p 307 (2021)
Fibrinogen is an abundant blood plasma protein that, inter alia, participates in blood coagulation. It polymerizes to form a fibrin clot that is among the major components of the thrombus. Fibrinogen reactions with various reactive metabolites may in
Externí odkaz: https://doaj.org/article/85a5c0b4f9084fce85c8fa524700afa1
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4
Extension of the Human Fibrinogen Database with Detailed Clinical Information—The αC-Connector Segment
Autor: Zofie Sovova, Klara Pecankova, Pavel Majek, Jiri Suttnar
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 132, p 132 (2022)
International Journal of Molecular Sciences
Fibrinogen, an abundant plasma glycoprotein, is involved in the final stage of blood coagulation. Decreased fibrinogen levels, which may be caused by mutations, are manifested mainly in bleeding and thrombotic disorders. Clinically relevant mutations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ababe5f51a123ec623d905191b916c80
https://www.mdpi.com/1422-0067/23/1/132
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5
Akademický článek
Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease
Autor: Martin Hajsl, Alzbeta Hlavackova, Karolina Broulikova, Martin Sramek, Martin Maly, Jan E. Dyr, Jiri Suttnar
Publikováno v: Metabolites, Vol 10, Iss 5, p 208 (2020)
Atherosclerosis is a leading cause of major vascular events, myocardial infarction, and ischemic stroke. Tryptophan (TRP) catabolism was recognized as an important player in inflammation and immune response having together with oxidative stress (OS)
Externí odkaz: https://doaj.org/article/b1bb9d730fd34a5583d28faa8b43987c
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6
Akademický článek
Effect of Blood Component Coatings of Enosseal Implants on Proliferation and Synthetic Activity of Human Osteoblasts and Cytokine Production of Peripheral Blood Mononuclear Cells
Autor: Lucie Himmlova, Dana Kubies, Hana Hulejova, Jirina Bartova, Tomas Riedel, Jana Stikarova, Jiri Suttnar, Vlasta Pesakova
Publikováno v: Mediators of Inflammation, Vol 2016 (2016)
The study monitored in vitro early response of connective tissue cells and immunocompetent cells to enosseal implant materials coated by different blood components (serum, activated plasma, and plasma/platelets) to evaluate human osteoblast prolifera
Externí odkaz: https://doaj.org/article/76f7dc76c9454f9d98dcc3161c78905f
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7
Incorporation of Fibrin, Platelets, and Red Blood Cells into a Coronary Thrombus in Time and Space
Autor: Martin Hajšl, Ondrej Kucerka, Jan E. Dyr, Petr Tousek, John W. Weisel, Jirina Kaufmanova, Martin Maly, Jiri Suttnar, Jana Štikarová, Roman Kotlín, Tomáš Riedel
Publikováno v: Thrombosis and haemostasis. 122(3)
We describe the internal structure, spatial organization and dynamic formation of coronary artery thrombi from ST-segment elevation myocardial infarction patients. Scanning electron microscopy (SEM) revealed significant differences among four groups
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73edd644f3f4c3e9c6a7c4864fcb133
https://pubmed.ncbi.nlm.nih.gov/34781375
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10
Molecular Dynamic Simulations Suggest That Metabolite-Induced Post-Translational Modifications Alter the Behavior of the Fibrinogen Coiled-Coil Domain
Autor: Jiri Suttnar, Jan E. Dyr, Zofie Sovova
Publikováno v: Metabolites
Volume 11
Issue 5
Metabolites, Vol 11, Iss 307, p 307 (2021)
Fibrinogen is an abundant blood plasma protein that, inter alia, participates in blood coagulation. It polymerizes to form a fibrin clot that is among the major components of the thrombus. Fibrinogen reactions with various reactive metabolites may in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d8adad9fb6b3fd73f1eb4f25464b80
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