Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Jiri, Damborsky"'
Autor:
Gabin de La Bourdonnaye, Tereza Ghazalova, Petr Fojtik, Katerina Kutalkova, David Bednar, Jiri Damborsky, Vladimir Rotrekl, Veronika Stepankova, Radka Chaloupkova
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 942-951 (2024)
FGF21 is an endocrine signaling protein belonging to the family of fibroblast growth factors (FGFs). It has emerged as a molecule of interest for treating various metabolic diseases due to its role in regulating glucogenesis and ketogenesis in the li
Externí odkaz:
https://doaj.org/article/dfa7bab639fc453cbad54a637e1e360f
Autor:
Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Ihor Arefiev, Joan Planas-Iglesias, Adam Dobias, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Ondrej Slaby, Jiri Damborsky, Stanislav Mazurenko, David Bednar
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Every year, more than 19 million cancer cases are diagnosed, and this number continues to increase annually. Since standard treatment options have varying success rates for different types of cancer, understanding the biology of an individua
Externí odkaz:
https://doaj.org/article/138a77a9475c4a66973983bff91f0986
Autor:
Gabin de La Bourdonnaye, Martin Marek, Tereza Ghazalova, Jiri Damborsky, Petr Pachl, Jiri Brynda, Veronika Stepankova, Radka Chaloupkova
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100112- (2024)
Fibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation. T
Externí odkaz:
https://doaj.org/article/4ac9464e85cb425fb008c0c9b8444e8b
Autor:
Sérgio M. Marques, Petr Kouba, Anthony Legrand, Jiri Sedlar, Lucas Disson, Joan Planas-Iglesias, Zainab Sanusi, Antonin Kunka, Jiri Damborsky, Tomas Pajdla, Zbynek Prokop, Stanislav Mazurenko, Josef Sivic, David Bednar
Publikováno v:
JACS Au, Vol 4, Iss 6, Pp 2228-2245 (2024)
Externí odkaz:
https://doaj.org/article/7910a03b1e3c466486a988ae2dbf68c8
Autor:
Michal Nemergut, Daniel Pluskal, Jana Horackova, Tereza Sustrova, Jan Tulis, Tomas Barta, Racha Baatallah, Glwadys Gagnot, Veronika Novakova, Marika Majerova, Karolina Sedlackova, Sérgio M. Marques, Martin Toul, Jiri Damborsky, Zbynek Prokop, David Bednar, Yves L. Janin, Martin Marek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational techniques are combined, revealing that imidazopyrazinone luciferins bind to an
Externí odkaz:
https://doaj.org/article/02510bf81fd243d0bfed12a6fdc366d5
Autor:
Michal Nemergut, Sérgio M. Marques, Lukas Uhrik, Tereza Vanova, Marketa Nezvedova, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonin Kunka, Anthony Legrand, Hana Hribkova, Veronika Pospisilova, Jiri Sedmik, Jan Raska, Zbynek Prokop, Jiri Damborsky, Dasa Bohaciakova, Zdenek Spacil, Lenka Hernychova, David Bednar, Martin Marek
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-25 (2023)
Abstract Background Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor for late-onset Alzheimer’s Disease (AD). Although ApoE4 differs from its non-pathological ApoE3 isoform only by the C112R mutation, the molecular mechanism o
Externí odkaz:
https://doaj.org/article/3de537d320b7425ab0b3c676809f76bd
Autor:
Jan Vilim, Tereza Ghazalova, Eliska Petulova, Aneta Horackova, Veronika Stepankova, Radka Chaloupkova, David Bednar, Jiri Damborsky, Zbynek Prokop
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5144-5152 (2023)
The fibroblast growth factors (FGF) family holds significant potential for addressing chronic diseases. Specifically, recombinant FGF18 shows promise in treating osteoarthritis by stimulating cartilage formation. However, recent phase 2 clinical tria
Externí odkaz:
https://doaj.org/article/b9882663e7f7404ab12a98d53a7f7ccd
Autor:
Milos Musil, Andrej Jezik, Marie Jankujova, Jan Stourac, Jakub Galgonek, Saltuk Mustafa Eyrilmez, Jiri Vondrasek, Jiri Damborsky, David Bednar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6512-6518 (2022)
Protein tunnels are essential in transporting small molecules into the active sites of enzymes. Tunnels' geometrical and physico-chemical properties influence the transport process. The tunnels are attractive hot spots for protein engineering and dru
Externí odkaz:
https://doaj.org/article/14aa7edb75b64030812052db2895149c
Autor:
Jan Velecký, Marie Hamsikova, Jan Stourac, Milos Musil, Jiri Damborsky, David Bednar, Stanislav Mazurenko
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6339-6347 (2022)
Protein solubility is an attractive engineering target primarily due to its relation to yields in protein production and manufacturing. Moreover, better knowledge of the mutational effects on protein solubility could connect several serious human dis
Externí odkaz:
https://doaj.org/article/01996fd690c34e7e8edd9de1f51b18d1
Autor:
Dmitri Nikitin, Jan Mican, Martin Toul, David Bednar, Michaela Peskova, Patricia Kittova, Sandra Thalerova, Jan Vitecek, Jiri Damborsky, Robert Mikulik, Sarel J. Fleishman, Zbynek Prokop, Martin Marek
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1366-1377 (2022)
Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type. The discovery of bacterial and human plasminogen activators and their use as thrombolytic dru
Externí odkaz:
https://doaj.org/article/190a12128de241f4a06bec66f667421d