Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Jiraporn Ousingsawat"'
Autor:
Jiraporn Ousingsawat, Raquel Centeio, Nicole Reyne, Alexandra McCarron, Patricia Cmielewski, Rainer Schreiber, Gabriella diStefano, Dorothee Römermann, Ursula Seidler, Martin Donnelley, Karl Kunzelmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion. In the present study we investigated
Externí odkaz:
https://doaj.org/article/06c1135f56334127a708313a72426579
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9998 (2024)
Anoctamin 6 (ANO6, TMEM16F) is a phospholipid (PL) scramblase that moves PLs between both plasma membrane (PM) leaflets and operates as an ion channel. It plays a role in development and is essential for hemostasis, bone mineralization and immune def
Externí odkaz:
https://doaj.org/article/0f452d11a1b040139a043386fba58378
Autor:
Karl Kunzelmann, Raquel Centeio, Jiraporn Ousingsawat, Khaoula Talbi, Ursula Seidler, Rainer Schreiber
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTSLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gaine
Externí odkaz:
https://doaj.org/article/4fe0fe1fe0f14cb381bb1534fce08f9c
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss 5, Pp 590-604 (2021)
Externí odkaz:
https://doaj.org/article/d9d5f31db00c4ccda77fc5b462d6d210
Autor:
Karl Kunzelmann, Jiraporn Ousingsawat, Andre Kraus, Julien H. Park, Thorsten Marquardt, Rainer Schreiber, Björn Buchholz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13278 (2023)
The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to have more in common than initially suspected, as they all participate in the pathogenic process and clinical outcomes of airway and renal diseases. In the present rev
Externí odkaz:
https://doaj.org/article/60f567e65cd24e109be21a5d6bb4818e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
All vertebrate cells activate Cl– currents (ICl,swell) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1. However, apart from VRAC, the Ca2+-activated Cl– channel (CaCC) TMEM1
Externí odkaz:
https://doaj.org/article/cdbe9840da60450498b4ebddf3a7f66a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2998 (2022)
SLC26A9 is an epithelial anion transporter with a poorly defined function in airways. It is assumed to contribute to airway chloride secretion and airway surface hydration. However, immunohistochemistry showing precise localization of SLC26A9 in airw
Externí odkaz:
https://doaj.org/article/e474e2347fe84649a02b26322a973379
Autor:
Jiraporn Ousingsawat, Raquel Centeio, Inês Cabrita, Khaoula Talbi, Oliver Zimmer, Moritz Graf, Achim Göpferich, Rainer Schreiber, Karl Kunzelmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1085 (2022)
Repurposing of the anthelminthic drug niclosamide was proposed as an effective treatment for inflammatory airway diseases such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Niclosamide may also be effective for the treatment
Externí odkaz:
https://doaj.org/article/aed0ab4c2caa4ffba7172cf1eaf2cc07
Publikováno v:
Membranes, Vol 11, Iss 9, p 723 (2021)
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent phos
Externí odkaz:
https://doaj.org/article/5e0882f327974cd7ae8d780429728ead
Autor:
Raquel Centeio, Jiraporn Ousingsawat, Inês Cabrita, Rainer Schreiber, Khaoula Talbi, Roberta Benedetto, Tereza Doušová, Eric K. Verbeken, Kris De Boeck, Isaac Cohen, Karl Kunzelmann
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7852 (2021)
Activation of the Ca2+ activated Cl− channel TMEM16A is proposed as a treatment in inflammatory airway disease. It is assumed that activation of TMEM16A will induce electrolyte secretion, and thus reduce airway mucus plugging and improve mucociliar
Externí odkaz:
https://doaj.org/article/7df563b8230b4606afa44c639172b86c