Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jirí Novotný"'
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-33 (2024)
Abstract Amyloid β42 (Aβ42) plays a decisive role in the pathology of Alzheimer’s disease. The Aβ42 peptide can aggregate into various supramolecular structures, with oligomers being the most toxic form. However, different Aβ species that cause
Externí odkaz:
https://doaj.org/article/4f151de0003645d299688fddb0eefb4d
Autor:
Pinky Sultana, Jiri Novotny
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 912-936 (2024)
Clusterin is a ubiquitously expressed glycoprotein that is involved in a whole range of biological processes. This protein is known to promote tumor survival and resistance to therapy in cancer, which contrasts sharply with its neuroprotective functi
Externí odkaz:
https://doaj.org/article/cb168150b3c14bf3b7d596fb074aaeb0
Autor:
Daniel Vašek, Natálie Fikarová, Vendula Nagy Marková, Ondřej Honc, Lenka Pacáková, Bianka Porubská, Veronika Somova, Jiří Novotný, Barbora Melkes, Magdaléna Krulová
Publikováno v:
Journal of Inflammation, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background The transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reactions remains enigmatic. The conflicting data on its inflammatory role, suggesting both pro-inflammatory and
Externí odkaz:
https://doaj.org/article/9d52793d6d1144b881fc564f0d947549
Autor:
Lucie Hejnova, Zdenka Drastichova, Almos Boroš, Jaroslav Hrdlicka, Michal Behuliak, Jan Neckar, Josef Zicha, Jiri Novotny
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundThe consequences at the molecular level and the mechanisms involved in a possible cardioprotective effect of antihypertensive treatment are not yet fully understood. Here, the efficacy of pyridostigmine (PYR) and trandolapril (TRA) as antih
Externí odkaz:
https://doaj.org/article/4f179291797b43a19147cb6a315b3409
Autor:
Klára Gotvaldová, Jitka Špačková, Jiří Novotný, Kamila Baslarová, Petr Ježek, Lenka Rossmeislová, Jan Gojda, Katarína Smolková
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has been associated with the host dysmetabolism of branched-chain amino acids (BCAAs), however, the implications for the role of BCAA metabolism in PDAC development or progression are not cl
Externí odkaz:
https://doaj.org/article/9c8e633d23934de4801d995632b21d73
Publikováno v:
Journal of High Energy Physics, Vol 2023, Iss 12, Pp 1-86 (2023)
Abstract In this paper, we study celestial amplitudes of Goldstone bosons and conformal soft theorems. Motivated by the success of soft bootstrap in momentum space and the important role of the soft limit behavior of tree-level amplitudes, our goal i
Externí odkaz:
https://doaj.org/article/06859896dec846b7a6ad1bd27af3ecc2
Autor:
Pavla Taborska, Pavol Lukac, Dmitry Stakheev, Lenka Rajsiglova, Katerina Kalkusova, Karolina Strnadova, Lukas Lacina, Barbora Dvorankova, Jiri Novotny, Michal Kolar, Milena Vrana, Hana Cechova, Sarka Ransdorfova, Marie Valerianova, Karel Smetana, Luca Vannucci, Daniel Smrz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Soft tissue sarcomas are aggressive mesenchymal-origin malignancies. Undifferentiated pleomorphic sarcoma (UPS) belongs to the aggressive, high-grade, and least characterized sarcoma subtype, affecting multiple tissues and metastasizing to m
Externí odkaz:
https://doaj.org/article/1c9be3a664094753adfc79a34419345c
Autor:
Aneta Marvanova, Petr Kasik, Barbara Elsnicova, Veronika Tibenska, František Galatik, Daniela Hornikova, Veronika Zvolska, Pavel Vebr, Petr Vodicka, Lucie Hejnova, Petr Matous, Barbara Szeiff Bacova, Matus Sykora, Jiri Novotny, Jiri Neuzil, Frantisek Kolar, Olga Novakova, Jitka M. Zurmanova
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Moderate cold acclimation (MCA) is a non-invasive intervention mitigating effects of various pathological conditions including myocardial infarction. We aim to determine the shortest cardioprotective regimen of MCA and the response of β1/2/
Externí odkaz:
https://doaj.org/article/d34e3872bd694fb2a062b611ded5301a
Autor:
Vladimir Rudajev, Jiri Novotny
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-23 (2023)
Abstract Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and
Externí odkaz:
https://doaj.org/article/6f3c8bd9b9994db2951afd8edf5c355a
Autor:
Tereza Tykvartova, Matus Miklovic, Martin Kotrc, Petra Skaroupkova, Ludmila Kazdova, Jaroslava Trnovska, Vojtech Skop, Michal Kolar, Jiri Novotny, Vojtech Melenovsky
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract While phosphodiesterase‐5 inhibition (PED5i) may prevent hypertrophy and failure in pressure‐overloaded heart in an experimental model, the impact of PDE5i on volume‐overload (VO)‐induced hypertrophy is unknown. It is also unclear wh
Externí odkaz:
https://doaj.org/article/d062805e3709438687a940351a7af7a8