Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jiqing Guo"'
Autor:
Williams E. Miranda, Jiqing Guo, Haydee Mesa-Galloso, Valentina Corradi, James P. Lees-Miller, D. Peter Tieleman, Henry J. Duff, Sergei Yu. Noskov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiol
Externí odkaz:
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
Autor:
Jiqing Guo, Junlin Zhou
Publikováno v:
Asian Journal of Surgery, Vol 45, Iss 11, Pp 2339-2340 (2022)
Externí odkaz:
https://doaj.org/article/6d6f411d932d4d3ebbe4f34430e233f4
Autor:
Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, Farhan Zahid, James Lees-Miller, Sergei Yu. Noskov, Henry J. Duff
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Human-ether-a-go-go-related channel (hERG1) is the pore-forming domain of the delayed rectifier K+ channel in the heart which underlies the IKr current. The channel has been extensively studied due to its propensity to bind chemically diverse group o
Externí odkaz:
https://doaj.org/article/879c8e1fbdac4643966727b7d6174254
Autor:
Laura L. Perissinotti, Pablo M. De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C. Lee, Colleen E. Clancy, Henry J. Duff, Sergei Y. Noskov
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in h
Externí odkaz:
https://doaj.org/article/55a6b48ac7ca4144877062bf442031c9
Autor:
Jiqing Guo, Serdar Durdagi, Mohamed Changalov, Laura L Perissinotti, Jason M Hargreaves, Thomas G Back, Sergei Y Noskov, Henry J Duff
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e105553 (2014)
One of the main culprits in modern drug discovery is apparent cardiotoxicity of many lead-candidates via inadvertent pharmacologic blockade of K+, Ca2+ and Na+ currents. Many drugs inadvertently block hERG1 leading to an acquired form of the Long QT
Externí odkaz:
https://doaj.org/article/f7a4836d5fd74443b08ab39ad724be7c
Autor:
Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, James Lees-Miller, Mahdi Mousaei, Williams Miranda, Van A. Ngo, Sergei Yu Noskov, D. Peter Tieleman, Henry J. Duff
Publikováno v:
Biophysical Journal. 121:4585-4599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895d852b87ba1d2943131dcfe5ebfb59
https://doi.org/10.1016/j.bpj.2022.10.032
https://doi.org/10.1016/j.bpj.2022.10.032
Autor:
Joslyn Jung, Soren Wacker, Andrew D. Fant, Jiqing Guo, Williams E. Miranda, Mary Kudaibergenova, Sergei Y. Noskov, Henry J. Duff, Lei Shi, Andy Guan, Jianjing Cao, Kuo Hao Lee, Amy Hauck Newman, Therese Ku
Publikováno v:
J Chem Inf Model
Psychostimulant drugs, such as cocaine, inhibit dopamine reuptake via blockading the dopamine transporter (DAT), which is the primary mechanism underpinning their abuse. Atypical DAT inhibitors are dissimilar to cocaine and can block cocaine- or meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2210ef7eba1109d021c6032ff145c0da
https://doi.org/10.1021/acs.jcim.1c00856
https://doi.org/10.1021/acs.jcim.1c00856
Autor:
Henry J. Duff, James P. Lees-Miller, Valentina Corradi, Jiqing Guo, Williams E. Miranda, Haydee Mesa-Galloso, D. Peter Tieleman, Sergei Y. Noskov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity in various cell types. In this work, we combine molecular dynamics simulations, mutagenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ebaa10fb709ec926051bfcce623e66
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
Autor:
Sergei Y. Noskov, Williams E. Miranda, Colleen E. Clancy, Jiqing Guo, Henry J. Duff, Igor Vorobyov, Kevin R. DeMarco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 6
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
The human ether-á-go-go–related gene (hERG1) channel conducts small outward K(+) currents that are critical for cardiomyocyte membrane repolarization. The gain-of-function mutation N629D at the outer mouth of the selectivity filter (SF) disrupts i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f48c95afcebb85f80b44335862ef76
https://doi.org/10.1073/pnas.1909196117
https://doi.org/10.1073/pnas.1909196117
Publikováno v:
Biophys J
The human ether-a-go-go-related gene (hERG) encodes the voltage gated potassium channel (KCNH2 or Kv11.1, commonly known as hERG). This channel plays a pivotal role in the stability of phase 3 repolarization of the cardiac action potential. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ee5b116c2f3cc0233dba71dc6a8038
https://doi.org/10.1101/2020.09.11.293266
https://doi.org/10.1101/2020.09.11.293266
