Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jiongjia Cheng"'
For 2017, the estimated lifetime risk of developing colorectal cancer was 1 in 22. Even though preventative colonoscopy screening and standard-of-care surgery, radiation, and chemotherapy have decreased the death rate from colorectal cancer, new ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b82d912fe5924639ea536af375397f
https://doi.org/10.1158/0008-5472.c.6510210.v1
https://doi.org/10.1158/0008-5472.c.6510210.v1
Publikováno v:
Journal of medicinal chemistry.
Therapeutic peptides have revolutionized treatment for a number of human diseases. In particular, the past two decades have witnessed rapid progress of stapled helical peptides in drug discovery. Stapled helical peptides are chemically modified and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47fa939a79bb64445da83e7a1754c73
https://pubmed.ncbi.nlm.nih.gov/36580278
https://pubmed.ncbi.nlm.nih.gov/36580278
Publikováno v:
Tissue engineering. Part C, Methods, vol 26, iss 11
Tissue Eng Part C Methods
Tissue Eng Part C Methods
Despite considerable research effort, there is a significant need for safe agents that stimulate bone formation. Treatment of large or complex bone defects remains a challenge. Implantation of small molecule-induced human bone marrow-derived mesenchy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1c1b7d44b993db4e4b39b3dd751956
https://doi.org/10.1089/ten.tec.2020.0217
https://doi.org/10.1089/ten.tec.2020.0217
Autor:
Jiongjia Cheng, John R. Cashman
Publikováno v:
Investigational New Drugs. 39:131-141
Today, pancreatic cancer (PC) is a major health problem in the United States. It remains a challenge to develop efficacious clinically useful PC therapies. New avenues, based on translational approaches and innovative validated biomarkers could be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb86321641aa0b659d1bed7475027ee
https://doi.org/10.1007/s10637-020-00998-z
https://doi.org/10.1007/s10637-020-00998-z
Autor:
John R. Cashman, Jiongjia Cheng
Publikováno v:
Medicinal Chemistry Research. 29:1147-1159
Cancer is a major worldwide public health problem and is still the leading cause of death in the United States. There are many types of cancer treatment but completely successful results are oftentimes not attained. It remains a challenge to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb50792b452611b738a81b7c9ad1a957
https://doi.org/10.1007/s00044-020-02575-8
https://doi.org/10.1007/s00044-020-02575-8
Autor:
John R. Cashman, Jiongjia Cheng
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Today, pancreatic cancer (PC) remains a major health problem in the US. The fact that cancer stem cells (CSCs) become enriched in humans following anti-cancer therapy implicates CSCs as key contributors to tumor dormancy, metastasis, and relapse in P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c5895edef9d706fe539f17faf41ee5
http://europepmc.org/articles/PMC7280251
http://europepmc.org/articles/PMC7280251
Publikováno v:
Cancer Research. 78:5072-5083
For 2017, the estimated lifetime risk of developing colorectal cancer was 1 in 22. Even though preventative colonoscopy screening and standard-of-care surgery, radiation, and chemotherapy have decreased the death rate from colorectal cancer, new ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0e7d421d16eb53db6636b006d5bca2
https://doi.org/10.1158/0008-5472.can-17-2642
https://doi.org/10.1158/0008-5472.can-17-2642
Autor:
Emily A. Cashman, Stephanie Moore, John R. Cashman, Mary Dwyer, Karl J. Okolotowicz, Mark Mercola, Jiongjia Cheng, Daniel P. Ryan
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:4441-4451
For adult women in the United States, breast cancer is the most prevalent form of cancer. Compounds that target dysregulated signal transduction can be efficacious anti-cancer therapies. A prominent signaling pathway frequently dysregulated in breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43040e69a28156b3994d59e09e374a97
https://doi.org/10.1016/j.bmc.2018.07.042
https://doi.org/10.1016/j.bmc.2018.07.042
Autor:
Dong-Hoon Lee, Jiongjia Cheng, Karl J. Okolotowicz, Jorge Gomez-Galeno, Stephanie Moore, John R. Cashman
Publikováno v:
J Pharmacol Exp Ther
Prostate cancer (PCa) is the second leading cause of cancer-related death for men in the United States. Approximately 35% of PCa recurs and is often transformed to castration-resistant prostate cancer (CRPCa), the most deadly and aggressive form of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cc7ba85e8f9c73d769b2fd8122c150
https://pubmed.ncbi.nlm.nih.gov/31582422
https://pubmed.ncbi.nlm.nih.gov/31582422
Autor:
Isaac Perea-Gil, Joseph C. Wu, Joseph J. Lancman, Karl J. Okolotowicz, Travis L. Biechele, Paul J. Bushway, P. Duc Si Dong, Randall T. Moon, Justine Quach, Arne A. N. Bruyneel, Wesley L. McKeithan, Jiongjia Cheng, Mark Mercola, Jaechol Lee, Nirmal Vadgama, Mary Dwyer, Ioannis Karakikes, John R. Cashman, Masanao Tsuda, Dennis Schade, Alexandre R. Colas
Publikováno v:
Cell Chem Biol
Summary Wnt signaling plays a central role in tissue maintenance and cancer. Wnt activates downstream genes through β-catenin, which interacts with TCF/LEF transcription factors. A major question is how this signaling is coordinated relative to tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d6a9872a25e9967041888044eeee60
https://doi.org/10.1016/j.chembiol.2021.01.001
https://doi.org/10.1016/j.chembiol.2021.01.001