Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Jiong Lan"'
Autor:
Yini Wang, Bowen Zhong, Caixia Xu, Dongdong Zhan, Songhao Zhao, Hongxing Wu, Mingwei Liu, Xiaoling Lan, Danni Cai, Qian Ding, Biao Zheng, Jiong Lan, Qiang Lv, Yi Wang, Jun Qin
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106080- (2023)
Summary: KRAS inhibitor AMG510 covalently modifies the G12C residue and inactivates the KRAS/G12C function. Because there are many reactive cysteines in the proteome, it is important to characterize AMG510 on-target modification and off-targets. Here
Externí odkaz:
https://doaj.org/article/9a4afe9420004336b5267b4bc69fddcf
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 166K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ad7594fcd5df49250ddfdaff9459d2
https://doi.org/10.1158/1541-7786.22511388
https://doi.org/10.1158/1541-7786.22511388
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 74K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab586f9613d97b5fef19284a31f81a52
https://doi.org/10.1158/1541-7786.22511394
https://doi.org/10.1158/1541-7786.22511394
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 28K, Percent Inhibition of MDA-MB-231 or H358 cells when grown as colonies on Scivax plates in the presence of LJI308.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac94484c1d0dc1a9aeed55e1da54f5f1
https://doi.org/10.1158/1541-7786.22511382
https://doi.org/10.1158/1541-7786.22511382
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
PDF file - 650K, Figure S1. RSK N-terminal Kinase Directly Phosphorylates YB1 on Ser102. COS7 cells either (A) untransfected or (B) transiently expressing WT RSK2 or T493M RSK2 were placed under serum starvation conditions for 20 hrs, followed by 3 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0775c12e2c455a77f0f6170b2bd449e4
https://doi.org/10.1158/1541-7786.22511391
https://doi.org/10.1158/1541-7786.22511391
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
The p90 ribosomal S6 kinase (RSK) family of serine/threonine kinases is expressed in a variety of cancers and its substrate phosphorylation has been implicated in direct regulation of cell survival, proliferation, and cell polarity. This study charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8ae1dcb5259c892f097fe0a3db0af33
https://doi.org/10.1158/1541-7786.c.6539931.v1
https://doi.org/10.1158/1541-7786.c.6539931.v1
Autor:
Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik
XLSX file - 27K, Competition binding of LJH685, LJI308, BI-D1870-AE, and FMK-PA at 10 microM concentration to either 96 or 492 kinases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c710e99010aa509d4e83e6d2196235f
https://doi.org/10.1158/1541-7786.22511385.v1
https://doi.org/10.1158/1541-7786.22511385.v1
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers and show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b7a0911566c282b44322df88773977
https://doi.org/10.1158/1078-0432.c.6522398
https://doi.org/10.1158/1078-0432.c.6522398
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Figure 3. KINO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cf370c3ede2546f0f7aab800bf1d63
https://doi.org/10.1158/1078-0432.22452158.v1
https://doi.org/10.1158/1078-0432.22452158.v1
Autor:
Pablo Garcia, Gisele Nishiguchi, Wooseok Han, Mika Lindvall, Cornelia Bellamacina, Yumin Dai, Matthew Burger, John L. Langowski, Richard Zang, Zheng Chen, Gordana Atallah, Song Lin, Paul Feucht, Jiong Lan, Yu Ding, Alice Rico, Tatiana Zavorotinskaya
Publikováno v:
Journal of Medicinal Chemistry. 63:14885-14904
Overexpression of PIM 1, 2, and 3 kinases is frequently observed in many malignancies. Previously, we discovered a potent and selective pan-PIM kinase inhibitor, compound 2, currently in phase I clinical trials. In this work, we were interested in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a2e2a773b3d977656af5f3b13f2c0a
https://doi.org/10.1021/acs.jmedchem.0c01279
https://doi.org/10.1021/acs.jmedchem.0c01279