Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jinyue Pu"'
Publikováno v:
eLife, Vol 10 (2021)
The roles of chance, contingency, and necessity in evolution are unresolved because they have never been assessed in a single system or on timescales relevant to historical evolution. We combined ancestral protein reconstruction and a new continuous
Externí odkaz:
https://doaj.org/article/cbd4a960942f48688a4bc4cbdf8ec653
Publikováno v:
Biochemistry.
The structurally conserved B-cell Lymphoma 2 (Bcl-2) family of proteins function to promote or inhibit apoptosis through an exceedingly complex web of specific, intrafamilial protein-protein interactions. The critical role of these proteins in lympho
Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl‑1 and Bcl‑2.
Publikováno v:
Biochemistry; 6/6/2023, Vol. 62 Issue 11, p1619-1630, 12p
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The roles of chance, contingency, and necessity in evolution are unresolved because they have never been assessed in a single system or on timescales relevant to historical evolution. We combined ancestral protein reconstruction and a new continuous
Autor:
Chao Peng, Gong-Li Tang, Wan-Hong Wen, Man-Cheng Tang, Yue Zhang, Liwen Zhang, Yuquan Xu, Jinyue Pu
Publikováno v:
Proceedings of the National Academy of Sciences. 115:11232-11237
Understanding how antibiotic-producing bacteria deal with highly reactive chemicals will ultimately guide therapeutic strategies to combat the increasing clinical resistance crisis. Here, we uncovered a distinctive self-defense strategy featured by a
Publikováno v:
ACS Chemical Biology. 13:431-437
Systems to control Cas9 with spatial and temporal precision offer opportunities to decrease side effects, protect sensitive tissues, and create gene therapies that are only activated at defined times and places. Here, we present the design of new Cas
Publikováno v:
Journal of the American Chemical Society. 139:11964-11972
We report the development of a new technology for monitoring multidimensional protein-protein interactions (PPIs) inside live mammalian cells using split RNA polymerase (RNAP) tags. In this new system, a protein-of-interest is tagged with an N-termin
Evolution of C-Terminal Modification Tolerance in Full-Length and Split T7 RNA Polymerase Biosensors
Publikováno v:
Chembiochem
T7 RNA polymerase (RNAP) is a powerful protein scaffold for the construction of synthetic biology tools and biosensors. However, both T7 RNAP and its split variants are intolerant to C-terminal modifications or fusions, placing a key limitation on it
Autor:
Xie, Victoria Cochran, Jinyue Pu, Metzger, Brian PH, Thornton, Joseph W., Dickinson, Bryan C.
Publikováno v:
eLife; 7/15/2021, p1-34, 34p