Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jinxu Cao"'
Autor:
Yixian Li, Peng Yang, Ran Meng, Shuting Xu, Lingling Zhou, Kang Qian, Pengzhen Wang, Yunlong Cheng, Dongyu Sheng, Minjun Xu, Tianying Wang, Jing Wu, Jinxu Cao, Qizhi Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1380-1399 (2024)
Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer's disease (AD) collectively culminate in neuronal deterioration. In the context of AD, autophagy dysfunction, a multi-link obstacle involving autophagy down
Externí odkaz:
https://doaj.org/article/8bd04ee938174169b40471e454fdf68d
Autor:
Shuting Xu, Peng Yang, Kang Qian, Yixian Li, Qian Guo, Pengzhen Wang, Ran Meng, Jing Wu, Jinxu Cao, Yunlong Cheng, Minjun Xu, Qizhi Zhang
Publikováno v:
Bioactive Materials, Vol 11, Iss , Pp 300-316 (2022)
Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis, which represents a hallmark of Alzheimer's disease (AD) and other age-related neurodegenerative disorders. Growing evidence has implic
Externí odkaz:
https://doaj.org/article/38cdd5f5995b4da78d49ad7b81c7193b
Autor:
Qian Guo, Xiaoyao Zheng, Peng Yang, Xiaoying Pang, Kang Qian, Pengzhen Wang, Shuting Xu, Dongyu Sheng, Liuchang Wang, Jinxu Cao, Wei Lu, Qizhi Zhang, Xinguo Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 3, Pp 590-603 (2019)
Gene therapy represents a promising treatment for the Alzheimer׳s disease (AD). However, gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able
Externí odkaz:
https://doaj.org/article/bb849093345041d0b3fd7ec9bb9ad94e
Autor:
Qian Guo, Yixian Li, Shuting Xu, Pengzhen Wang, Kang Qian, Peng Yang, Dongyu Sheng, Liuchang Wang, Yunlong Cheng, Ran Meng, Jinxu Cao, Haichang Luo, Yan Wei, Qizhi Zhang
Publikováno v:
Journal of Controlled Release. 355:604-621
Publikováno v:
New Journal of Chemistry. 47:5773-5779
Bio-activity conservation of biomolecules after immobilizing in nanomaterials has been a tough challenge, especially in biomedical applications.
Autor:
Yunlong Cheng, Xiaoying Pang, Jing Wu, Lingling Zhou, Jinxu Cao, Liuchang Wang, Kang Qian, Peng Yang, Minjun Xu, Dongyu Sheng, Ran Meng, Pengzhen Wang, Qian Guo, Shuting Xu, Yan Wei, Qizhi Zhang
Publikováno v:
Drug Delivery and Translational Research.
Autor:
Yunlong Cheng, Qizhi Zhang, Jing Wu, Yixian Li, Ran Meng, Shuting Xu, Qian Guo, Peng Yang, Pengzhen Wang, Kang Qian, Minjun Xu, Jinxu Cao
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 11, Iss, Pp 300-316 (2022)
Bioactive Materials, Vol 11, Iss, Pp 300-316 (2022)
Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis, which represents a hallmark of Alzheimer's disease (AD) and other age-related neurodegenerative disorders. Growing evidence has implic
Autor:
Kang Qian, Xiaoyan Bao, Yixian Li, Pengzhen Wang, Qian Guo, Peng Yang, Shuting Xu, Fazhi Yu, Ran Meng, Yunlong Cheng, Dongyu Sheng, Jinxu Cao, Minjun Xu, Jing Wu, Tianying Wang, Yonghui Wang, Qiong Xie, Wei Lu, Qizhi Zhang
Publikováno v:
ACS nano. 16(7)
Mitochondrial dysfunction in neurons has recently become a promising therapeutic target for Alzheimer's disease (AD). Regulation of dysfunctional mitochondria through multiple pathways rather than antioxidation monotherapy indicates synergistic thera
Autor:
Kang Qian, Dongyu Sheng, Jinxu Cao, Qian Guo, Qizhi Zhang, Peng Yang, Shuting Xu, Shuai Lu, Pengzhen Wang, Wei Lu
Publikováno v:
Journal of Controlled Release. 320:347-362
The presence of blood-brain barrier (BBB) and specificity of neuron targeting remain two challenges in the effective delivery of nanotherapeutics for the treatment of Alzheimers disease (AD). Traditional strategy of nanocarriers for AD treatment invo
Autor:
Pengzhen Wang, Peng Yang, Kang Qian, Yixian Li, Shuting Xu, Ran Meng, Qian Guo, Yunlong Cheng, Jinxu Cao, Minjun Xu, Wei Lu, Qizhi Zhang
Publikováno v:
Biomaterials. 281
Intervention of the over-activated microglia-aggravated neuroinflammation represents a promising therapeutic strategy for Alzheimer's disease (AD). Upregulation of triggering receptor expressed on myeloid cells-2 (TREM2) attenuates the neuroinflammat