Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jinxiu Rui"'
Autor:
Jinxiu Rui, Songyan Deng, Ana Luisa Perdigoto, Gerald Ponath, Romy Kursawe, Nathan Lawlor, Tomokazu Sumida, Maya Levine-Ritterman, Michael L. Stitzel, David Pitt, Jun Lu, Kevan C. Herold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2
Externí odkaz:
https://doaj.org/article/d2099481cf7c45539fc5dd7688d09511
Autor:
Sahar Usmani-Brown, Ana Luisa Perdigoto, Nathalie Lavoie, Pamela Clark, Maria Korah, Jinxiu Rui, Gabriel Betancur, Kevan C. Herold
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp S104-S113 (2019)
Background: The extended and clinically silent progression of Type 1 diabetes (T1D) creates a challenge for clinical interventions and for understanding the mechanisms that underlie its pathogenesis. Over the course of the development of Type 1 diabe
Externí odkaz:
https://doaj.org/article/d0abada155ca4017a79a03a6bb97ffc5
Publikováno v:
Diabetes
Diabetes, 2022, 71 (8), pp.1603-1610. ⟨10.2337/dbi21-0036⟩
Diabetes, 2022, 71 (8), pp.1603-1610. ⟨10.2337/dbi21-0036⟩
International audience; Recent reports have revived interest in the active role that β-cells may play in type 1 diabetes pathogenesis at different stages of disease. In some studies, investigators suggested an initiating role and proposed that type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2529621ffc8d5a34d499a711e2ab08a0
https://www.hal.inserm.fr/inserm-03834211
https://www.hal.inserm.fr/inserm-03834211
Autor:
Ana Luisa Perdigoto, Sahar Usmani-Brown, Pamela Clark, Gabriel Betancur, Nathalie Lavoie, Jinxiu Rui, Kevan C. Herold, Maria Korah
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 27, Iss, Pp S104-S113 (2019)
Molecular Metabolism, Vol 27, Iss, Pp S104-S113 (2019)
Background: The extended and clinically silent progression of Type 1 diabetes (T1D) creates a challenge for clinical interventions and for understanding the mechanisms that underlie its pathogenesis. Over the course of the development of Type 1 diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f22b0a4b0c7ed1c81f21dadf673274
http://europepmc.org/articles/PMC6768505
http://europepmc.org/articles/PMC6768505
Autor:
David Pitt, Jinxiu Rui, Kevan C. Herold, Ana Luisa Perdigoto, Romy Kursawe, Tomokazu Sumida, Maya Levine-Ritterman, Nathan Lawlor, Jun Lu, Gerald Ponath, Michael L. Stitzel, Songyan Deng
β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). We identified a novel role of Tet2 in regulating immune killing of β cells. Tet2 is induced in murine and human β cells with inflammation but its expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f62b70e0d06dd60514414bd782489956
https://doi.org/10.1101/2020.09.01.278028
https://doi.org/10.1101/2020.09.01.278028
Publikováno v:
Current Opinion in Immunology. 49:44-50
Studies with immunologics have shown that the natural history of Type 1 diabetes can be modified. These studies have targeted key mediators of the disease and recent analyses, together with studies in preclinical models have identified mechanisms tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578e4b3ec5a137446c61e76a47e31cc8
https://doi.org/10.1016/j.coi.2017.09.004
https://doi.org/10.1016/j.coi.2017.09.004
Autor:
Steven H. Kleinstein, Justin Garyu, Jinxiu Rui, Matt M. Staron, Jared A. Shenson, Mohamed Uduman, Kevan C. Herold, Susan M. Kaech, Alex Stewart, Songyan Deng
Publikováno v:
Journal of Biological Chemistry. 291:11230-11240
Type 1 diabetes mellitus is caused by the killing of insulin-producing β cells by CD8+T cells. The disease progression, which is chronic, does not follow a course like responses to conventional antigens such as viruses, but accelerates as glucose to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e25cbc4ee3a82e2cb85b09249793d60
https://doi.org/10.1074/jbc.m115.713362
https://doi.org/10.1074/jbc.m115.713362
Publikováno v:
Cell metabolism. 25(3)
Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune-mediated destruction of β cells. How β cells respond to immune attack is unknown. We identified a population of β cells during the progression of T1D in non-obese diabetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d037215c06824f7f4f2dcffe195b25
https://pubmed.ncbi.nlm.nih.gov/28232664
https://pubmed.ncbi.nlm.nih.gov/28232664
Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing pancreatic β cells. Immune modulators have achieved some success in modifying the course of disease progression in T1D. However, there are parallel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c78055e5da3b79db394e628aa6f2fd
https://escholarship.org/uc/item/6rc4g2pj
https://escholarship.org/uc/item/6rc4g2pj
Autor:
Justin W, Garyu, Mohamed, Uduman, Alex, Stewart, Jinxiu, Rui, Songyan, Deng, Jared, Shenson, Matt M, Staron, Susan M, Kaech, Steven H, Kleinstein, Kevan C, Herold
High levels of reactive oxygen species can facilitate DNA and protein damage beyond the control of endogenous antioxidants, resulting in oxidative stress. Oxidative stress then triggers inflammation, which can lead to pathological conditions. In gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4a17309f5a31d3861176d7b689ce6cd6
https://europepmc.org/articles/PMC4900270/
https://europepmc.org/articles/PMC4900270/