Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Jinwoo Ahn"'
Autor:
Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We observe that approximately 1–5% of CD4+ T cells from the bloo
Externí odkaz:
https://doaj.org/article/a62a5df966d346acae50282c12b35957
Autor:
Kwangrok Jung, Suhyun Choi, Hyunjoo Song, Kyuhan Kwak, Soyeon Anh, Jae Hyup Jung, Bomi Kim, Jinwoo Ahn, Jaihwan Kim, Jin-Hyeok Hwang, Jong-chan Lee
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: FOLFIRINOX, used in metastatic pancreatic cancer (MPC), is highly efficacious but also toxic. Various dose modifications for FOLFIRINOX have been introduced to reduce toxicity. However, these studies lack a unified pattern for ‘planned
Externí odkaz:
https://doaj.org/article/6b1ec99d35654bffb71305ea7a6d22ae
Autor:
Jong-Chan Lee, Brian J Lee, Changhee Park, Hyunjoo Song, Chan-Young Ock, Hyojae Sung, Sungjin Woo, Yuna Youn, Kwangrok Jung, Jae Hyup Jung, Jinwoo Ahn, Bomi Kim, Jaihwan Kim, Jinwook Seo, Jin-Hyeok Hwang
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281422 (2023)
PubMed is the most extensively used database and search engine in the biomedical and healthcare fields. However, users could experience several difficulties in acquiring their target papers facing massive numbers of search results, especially in thei
Externí odkaz:
https://doaj.org/article/0b0f0a881dfd4fbfbc9f09a421d174a8
Autor:
In-Ja L. Byeon, Guillermo Calero, Ying Wu, Chang H. Byeon, Jinwon Jung, Maria DeLucia, Xiaohong Zhou, Simon Weiss, Jinwoo Ahn, Caili Hao, Jacek Skowronski, Angela M. Gronenborn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Vpr is a HIV-1 accessory virulence factor that also interacts with the human DNA repair protein hHR23A. Here, the authors present the structure of Vpr in complex with the C-terminal half of hHR23A comprising the XPC-binding and ubiquitin-associated d
Externí odkaz:
https://doaj.org/article/f2cad48d7439439680a1cc4a66c3934c
Autor:
Jae Hyup Jung, Changhoon Song, In Ho Jung, Jinwoo Ahn, Bomi Kim, Kwangrok Jung, Jong-Chan Lee, Jaihwan Kim, Jin-Hyeok Hwang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionFOLFIRINOX (the combination of 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) is the preferred systemic regimen for locally advanced pancreatic cancer (LAPC). Furthermore, stereotactic body radiation therapy (SBRT) is a promisin
Externí odkaz:
https://doaj.org/article/e3b4c458fc414af0978b54cc05a2cbf5
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-9 (2021)
Abstract Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection. HIV-1 Vpr mediates proteasome-dependent degradation of several DNA repair/modification
Externí odkaz:
https://doaj.org/article/70e6a957d7ba4e07a87704d7c270a618
Autor:
Zhou Zhong, Jiying Ning, Emerson A. Boggs, Sooin Jang, Callen Wallace, Cheryl Telmer, Marcel P. Bruchez, Jinwoo Ahn, Alan N. Engelman, Peijun Zhang, Simon C. Watkins, Zandrea Ambrose
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
HIV is the causative agent of AIDS, which has no cure. The protein shell that encases the viral genome, the capsid, is critical for HIV replication in cells at multiple steps.
Externí odkaz:
https://doaj.org/article/7b45f007fb61477e9bb4e09bfd2fad63
Autor:
Chaoyi Xu, Douglas K Fischer, Sanela Rankovic, Wen Li, Robert A Dick, Brent Runge, Roman Zadorozhnyi, Jinwoo Ahn, Christopher Aiken, Tatyana Polenova, Alan N Engelman, Zandrea Ambrose, Itay Rousso, Juan R Perilla
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001015 (2020)
Reverse transcription, an essential event in the HIV-1 life cycle, requires deoxynucleotide triphosphates (dNTPs) to fuel DNA synthesis, thus requiring penetration of dNTPs into the viral capsid. The central cavity of the capsid protein (CA) hexamer
Externí odkaz:
https://doaj.org/article/1aa20b004af54e01aac2ef7867b6cf2f
Autor:
Junpeng Yan, Ming-Chieh Shun, Caili Hao, Yi Zhang, Juan Qian, Kasia Hrecka, Maria DeLucia, Christina Monnie, Jinwoo Ahn, Jacek Skowronski
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Viral accessory proteins hijack host cell E3 ubiquitin ligases to antagonize innate/intrinsic defenses and thereby provide a more permissive environment for virus replication. Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr
Externí odkaz:
https://doaj.org/article/56ce2447f8324b7eadd44ac5a495e2e4
Autor:
Chuang Liu, Juan R. Perilla, Jiying Ning, Manman Lu, Guangjin Hou, Ruben Ramalho, Benjamin A. Himes, Gongpu Zhao, Gregory J. Bedwell, In-Ja Byeon, Jinwoo Ahn, Angela M. Gronenborn, Peter E. Prevelige, Itay Rousso, Christopher Aiken, Tatyana Polenova, Klaus Schulten, Peijun Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid t
Externí odkaz:
https://doaj.org/article/3b563f433dd146d4b7f6b78da7c03c54