Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jinwang Ye"'
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 7, Pp 1489-1498 (2024)
Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older adults. Primary features of Alzheimer’s disease include extracellular aggregation of amyloid-β plaques and the accumulation of neurofibrillary tangles, formed by
Externí odkaz:
https://doaj.org/article/51fe74dfcc27414db5d0886d6638cd6c
Publikováno v:
Geomatics, Natural Hazards & Risk, Vol 14, Iss 1 (2023)
AbstractUnder global warming, the acceleration of the water cycle has increased the risk of drought in the Yellow River Basin. Revealing the drought driving mechanisms in the basin and understanding the risk situation of drought have become particula
Externí odkaz:
https://doaj.org/article/7b39d5d1f20e443699caf951c7d70c94
Publikováno v:
Molecules, Vol 28, Iss 9, p 3964 (2023)
Intracellular tau accumulation is a hallmark pathology of Alzheimer’s disease (AD) and other tauopathies. Tau protein, in the hyperphosphorylated form, is the component of paired helical filaments (PHFs) and neurofibrillary tangles (NFTs) in AD. Bl
Externí odkaz:
https://doaj.org/article/60e286ad132b44e5bde3dc937890d619
Autor:
Yanchao Liu, Shujuan Zhang, Benrong He, Liangkai Chen, Dan Ke, Shi Zhao, Yao Zhang, Wei Wei, Zhipeng Xu, Zihui Xu, Ying Yin, Wen Mo, Yanni Li, Yang Gao, Shihong Li, Weijin Wang, Huiling Yu, Dongqin Wu, Guilin Pi, Tao Jiang, Mingmin Deng, Rui Xiong, Huiyang Lei, Na Tian, Ting He, Fei Sun, Qiuzhi Zhou, Xin Wang, Jinwang Ye, Mengzhu Li, Nan Hu, Guoda Song, Wenju Peng, Chenghong Zheng, Huaqiu Zhang, Jian-Zhi Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Introduction: Type 2 diabetes mellitus (T2DM) is an independent risk factor of Alzheimer’s disease (AD), and populations with mild cognitive impairment (MCI) have high incidence to suffer from AD. Therefore, discerning who may be more vulnerable to
Externí odkaz:
https://doaj.org/article/b29d99b7765d4e7599b106d0eaac20e8
Autor:
Dongqin Wu, Di Gao, Haitao Yu, Guilin Pi, Rui Xiong, Huiyang Lei, Xin Wang, Enjie Liu, Jinwang Ye, Huilin Yu, Yang Gao, Ting He, Tao Jiang, Fei Sun, Jingfen Su, Guoda Song, Wenju Peng, Ying Yang, Jian‐Zhi Wang
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Abstract Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation in cholinergic lesion is elusive. Here, we observed an aberrant tau accumulation in the medi
Externí odkaz:
https://doaj.org/article/88ab01d94fe1451495d1b25853e669bc
Publikováno v:
Molecular Neurobiology. 59:6141-6157
Class IIa histone deacetylases (HDAC) have been shown to drive innate immune cell-mediated inflammation in the peripheral system, but their roles in cerebral inflammatory responses remain largely unknown. Here, we elucidate that HDAC7 is selectively
Autor:
Minmin Deng, Jinwang Ye, Qiuzhi Zhou, Weijin Wang, Tao Jiang, Dan Ke, Xin Wang, Yanchao Liu, Jian-Zhi Wang, Qun Wang, Jie Zheng, Shihong Li, Yipeng Wang
Publikováno v:
Theranostics
Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting tau could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) is a novel drug discovery strategy for
Class IIa histone deacetylase s (HDAC) have been shown to drive innate immune cell-mediated inflammation in the peripheral system, but their roles in cerebral inflammatory responses remain largely unknown. Here, we elucidate that HDAC7 is selectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71981f19f269c0d18de76e2f95fdeeb8
https://doi.org/10.21203/rs.3.rs-1462010/v1
https://doi.org/10.21203/rs.3.rs-1462010/v1
Autor:
Di Gao, Huiyang Lei, Rui Xiong, Tao Jiang, Fei Sun, Jinwang Ye, Dongqin Wu, Enjie Liu, Ting He, Jian-Zhi Wang, Xin Wang, Yang Gao, Guoda Song, Ying Yang, Huilin Yu, Jingfen Su, Guilin Pi, Haitao Yu, Wenju Peng
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Clinical and Translational Medicine
Clinical and Translational Medicine
Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation in cholinergic lesion is elusive. Here, we observed an aberrant tau accumulation in the medial septum
Autor:
Huaqiu Zhang, Yue Zuo, Mengzhu Li, Di Gao, Jian-Zhi Wang, Jinwang Ye, Yaling Yin, Ying Yin, Jun Li, Dan Ke, Yanchao Liu, Hua-Li Wan, Lu Wang
Publikováno v:
Aging Cell
Intracellular accumulating of the hyperphosphorylated tau plays a pivotal role in neurodegeneration of Alzheimer disease (AD), but the mechanisms underlying the gradually aggravated tau hyperphosphorylation remain elusive. Here, we show that increasi