Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jinu S. Mathew"'
Autor:
Fiona L. Rawlinson, Jones Matthew Cameron, Steven J. Fussell, John Pearce, Robert Walton, Clare L. Crook, Nieves Castro, Douglas James Critcher, Alexandra E. Sherlock, Lynne McMillan, Matthew Badland, Katherine J. Jones, E. Kougoulos, Adam T. Gillmore, Jinu S. Mathew
Publikováno v:
Organic Process Research & Development. 16:1897-1904
Novel PARP inhibitor 1 is a promising new candidate for treatment of breast and ovarian cancer. A modified synthetic route to 1 has been developed and demonstrated on 7 kg scale. In order to scale up the synthesis to multikilogram scale, several synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b0ec3b9d8b748f13b91ae07c03438d
https://doi.org/10.1021/op200238p
https://doi.org/10.1021/op200238p
Autor:
Jean-Philippe Crochard, Melissa Birch, Amy Luan, Jinu S. Mathew, Philip Peach, Neil McDowall, David Sebastien Fradet, Stephen Challenger, Kevin Meldrum, Charles M. Gordon, Hayley Jackman, Stephen Yeo, Evelyn Madigan
Publikováno v:
Organic Process Research & Development. 15:1358-1364
The development of a highly efficient two-step process for the manufacture of the α2δ-ligand imagabalin hydrochloride 1 is described in 50% overall yield from (R)-3-methylhexanoic acid 2. Key aspec...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9685f05fa65964e82bc79b3bfd7a2f4a
https://doi.org/10.1021/op2002326
https://doi.org/10.1021/op2002326
Autor:
Andrew J. Bibb, Petar I. Nikiforov, Stuart Field, Steven J. Fussell, Olivier Dirat, Mason Clive Philip, Alan John Pettman, Colin M. Burns, Green Stuart, Ian B. Moses, Jinu S. Mathew, Graham Checksfield, Barry Richard Dillon, Flavien Susanne, Suju Mathew
Publikováno v:
Organic Process Research & Development. 15:1010-1017
We report the discovery and optimization of an amine-promoted Friedel–Crafts alkylation of cinnamaldehyde with 4-hydroxymethyl phenol. This reaction has been used successfully on commercial scale (200 kg) in the context of the manufacture of fesote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac12c5d6e2599650d59bca0d61c550ab
https://doi.org/10.1021/op200107g
https://doi.org/10.1021/op200107g
Autor:
Colin Brennan, Donna G. Blackmond, Ian W. Ashworth, Malcolm Purdy, Antonio C. Ferretti, Jinu S. Mathew
Publikováno v:
Advanced Synthesis & Catalysis. 350:1007-1012
Healthy competition: The Pd(binap)-catalyzed amination of aryl halides demonstrates how the results from competitive reactions can be strikingly different from those obtained from study of the separate reactions. We show how the competitive network p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff6e004b390993273a0ce73af744531
https://doi.org/10.1002/adsc.200800006
https://doi.org/10.1002/adsc.200800006
Publikováno v:
Industrial & Engineering Chemistry Research. 46:8584-8589
Reaction calorimetry can be employed for kinetic studies of complex catalytic reactions. In the calorimeter, the enthalpy balance around the reactor is continuously monitored and gives a profile of reaction heat vs time, which can be easily expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8959e959115a65d710110f8be9fe0eb7
https://doi.org/10.1021/ie070050d
https://doi.org/10.1021/ie070050d
Autor:
Caroline Loew, Andreas Pfaltz, Jinu S. Mathew, Thorsten Rosner, Thomas Schultz, Donna G. Blackmond
Publikováno v:
Synlett. 2006:3135-3139
Comprehensive kinetic screening of Pd catalysts for Heck reactions via a consecutive pulse reaction methodology allows a more informed choice of catalyst for a particular transformation, taking into account not only initial reactivity but also long-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::016d6c73dce5a55ea793b81df0988b5f
https://doi.org/10.1055/s-2006-951514
https://doi.org/10.1055/s-2006-951514
Autor:
Per Ryberg, Shashank Shekhar, Jinu S. Mathew, Eric R. Strieter, Donna G. Blackmond, John F. Hartwig, Stephen L. Buchwald
Publikováno v:
Journal of the American Chemical Society. 128:3584-3591
Two previous mechanistic studies of the amination of aryl halides catalyzed by palladium complexes of 1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine) (BINAP) are reexamined by the authors of both studies. This current work includes a detailed stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c815cd12a17603a9f0119816931961
https://doi.org/10.1021/ja045533c
https://doi.org/10.1021/ja045533c
Publikováno v:
Catalysis of Organic Reactions ISBN: 9781420070767
Catalysis of Organic Reactions: Twenty-second Conference
Catalysis of Organic Reactions: Twenty-second Conference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4e0e9b30b1e9c1e3ab57b270ab61fab
https://doi.org/10.1201/9781420070774.ch26
https://doi.org/10.1201/9781420070774.ch26
Investigations of Pd-Catalyzed ArX Coupling Reactions Informed by Reaction Progress Kinetic Analysis
Autor:
Jinu S. Mathew, Donna G. Blackmond, Alan Futran, Martin Klussmann, Hiroshi Iwamura, Fernando E. Valera, Emma Anna Carolina Emanuelsson
Publikováno v:
ChemInform. 37
This Perspective highlights how the methodology of reaction progress kinetic analysis can provide a rapid and comprehensive kinetic profile of complex catalytic reaction networks under synthetically relevant conditions in a fraction of the number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3819aac7dc709a01d026008996bc2d5
https://doi.org/10.1002/chin.200643223
https://doi.org/10.1002/chin.200643223
Autor:
Melissa Birch, Stephen Challenger, Jean-Philippe Crochard, David Fradet, Hayley Jackman, Amy Luan, Evelyn Madigan, Jinu S. Mathew, Neil McDowall, Kevin Meldrum, Charles M. Gordon, Philip Peach, Stephen Yeo
Publikováno v:
Organic Process Research & Development; Nov2011, Vol. 15 Issue 6, p1358-1364, 7p