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pro vyhledávání: '"Jintong Zhou"'
Autor:
Jintong Zhou, Mingyu Xia, Zhenghui Huang, Hang Qiao, Guang Yang, Yunan Qian, Peifeng Li, Zhaolun Zhang, Xinai Gao, Lubin Jiang, Jing Wang, Wei Li, Pengfei Fang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code, serving as attractive drug targets. Within this family, the lysyl-tRNA synthetase (LysRS) constitutes a promising antimalarial target. ASP3026, an ana
Externí odkaz:
https://doaj.org/article/74cbcfff29fa40fc9e97ade5313b1537
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Structures of E. coli threonyl-tRNA synthetase in complex with natural product obafluorin (OB) reveal that OB is a unique covalent inhibitor.
Externí odkaz:
https://doaj.org/article/55ae5078a05f471b8069e492fd5a00e5
Aminoacyl-tRNA synthetases (AARSs), a family of essential protein synthesis enzymes, are attractive targets for drug development. Although several different types of AARS inhibitors have been identified, AARS covalent inhibitors have not been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c0ba0c9438be884e043e88e5b58b66
https://doi.org/10.21203/rs.3.rs-2245093/v1
https://doi.org/10.21203/rs.3.rs-2245093/v1
Publikováno v:
Biochemical and Biophysical Research Communications. 549:164-170
General control nonderepressible 2 (GCN2) is a serine/threonine protein kinase, detecting a variety of stresses including amino acid starvation, reactive oxygen species, etc. in eukaryotic cells. Activation of GCN2 requires the interaction of the N-t
Autor:
Yu Biao, Zhoufei Hei, Zhenghui Huang, Li Zheng, Jing Wang, Jintong Zhou, Zhi-Yong Wang, Lubin Jiang, Pengfei Fang
Publikováno v:
Nucleic Acids Research
Aminoacyl-tRNA synthetases are attractive targets for the development of antibacterial, antifungal, antiparasitic agents and for the treatment of other human diseases. Lysyl-tRNA synthetase (LysRS) from this family has been validated as a promising t
Publikováno v:
ACS Chemical Biology. 15:1016-1025
Aminoacyl-tRNA synthetases, the essential enzyme family for protein translation, are attractive targets for developing antibacterial, antifungal, and antiparasitic agents and for treating other human diseases. The antimalarial natural product cladosp
Publikováno v:
Biochemical and biophysical research communications. 554
Aminoacyl-tRNA synthetases (AARSs) catalyze the ligation of amino acids to their cognate tRNAs and therefore play an essential role in protein biosynthesis in all living cells. The KARS gene in human encodes both cytosolic and mitochondrial lysyl-tRN