Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jinti Wang"'
Autor:
Kristin Taborn, Joseph Ligutti, Josie H. Lee, Thomas Kornecook, Dong Liu, Dawn Zhu, Stephen Altmann, Ruoyuan Yin, Xuhai Be, Robert T. Fremeau, Jinti Wang, John Roberts, David J. Matson, Danielle Johnson, Violeta Yu, Christopher P Ilch, Bryan D. Moyer, Jason A. Luther, Virginia Berry, Matthew Weiss, Danny Ortuno, Michael Jarosh, Sonya G. Lehto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:146-160
Potent and selective antagonists of the voltage-gated sodium channel NaV1.7 represent a promising avenue for the development of new chronic pain therapies. We generated a small molecule atropisomer quinolone sulfonamide antagonist AMG8379 and a less
Autor:
Jamie A. Ashby, Dennis A. Dougherty, Neil J. Harrison, Darren L. Beene, Jinti Wang, Sarah C. R. Lummis, Katherine S. Millen
Publikováno v:
ACS Chemical Neuroscience
The ligand binding site of Cys-loop receptors is dominated by aromatic amino acids. In GABA(C) receptors, these are predominantly tyrosine residues, with a number of other aromatic residues located in or close to the binding pocket. Here we examine t
Autor:
Todd Scheuer, Vladimir Yarov-Yarovoy, Michael Gurevitz, William A. Catterall, Jinti Wang, Roy Kahn, Dalia Gordon
Publikováno v:
Proceedings of the National Academy of Sciences. 108:15426-15431
The α-scorpions toxins bind to the resting state of Na + channels and inhibit fast inactivation by interaction with a receptor site formed by domains I and IV. Mutants T1560A, F1610A, and E1613A in domain IV had lower affinities for Leiurus quinques
Publikováno v:
Journal of Biological Chemistry. 282:26210-26216
gamma-Aminobutyric acid type A (GABA(A)) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. Upon agonist binding, the receptor undergoes a structural transition from the closed to the open state, but the mechanism of gati
Autor:
Jinti Wang, Dalia Gordon, Todd Scheuer, Vladimir Yarov-Yarovoy, Michael Gurevitz, Roy Kahn, William A. Catterall
Author(s): Wang, Jinti; Yarov-Yarovoy, Vladimir; Kahn, Roy; Gordon, Dalia; Gurevitz, Michael; Scheuer, Todd; Catterall, William A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8fe91ef6badb673d2d60be66c63ae7
https://europepmc.org/articles/PMC3948248/
https://europepmc.org/articles/PMC3948248/
Autor:
Michael Gurevitz, Jinti Wang, Roy Kahn, Maya Gur, Izhar Karbat, Dalia Gordon, Noa Regev, William A. Catterall
Neurotoxin receptor site-3 at voltage-gated Na(+) channels is recognized by various peptide toxin inhibitors of channel inactivation. Despite extensive studies of the effects of these toxins, their mode of interaction with the channel remained to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06aa10099cb6e70fe30707498c5d655
https://europepmc.org/articles/PMC3186375/
https://europepmc.org/articles/PMC3186375/
Publikováno v:
The Journal of biological chemistry. 280(50)
In the Cys loop superfamily of ligand-gated ion channels, a global conformational change, initiated by agonist binding, results in channel opening and the passage of ions across the cell membrane. The detailed mechanism of channel gating is a subject
Publikováno v:
Journal of Biological Chemistry. 9/7/2007, Vol. 282 Issue 36, p26210-26216. 7p. 2 Diagrams, 3 Charts, 2 Graphs.
Autor:
Todd Scheuer, Roy Kahn, William A. Catterall, Jinti Wang, Dalia Gordon, Vladimir Yarov-Yarovoy, Michael Gurevitz
Publikováno v:
Biophysical Journal. (3):422a
Voltage-gated sodium channels are responsible for initiation and propagation of action potentials in nerve and muscle. α-Scorpion toxins, including LqhII (Leiurus quinquestriatus hebraeus, type II), bind to the extracellular face of the sodium chann
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