Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jinshu Xu"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Kidney formation and nephrogenesis are controlled by precise spatiotemporal gene expression programs, which are coordinately regulated by cell-cycle, cell type-specific transcription factors and epigenetic/chromatin regulators. However, the roles of
Externí odkaz:
https://doaj.org/article/8112a2758bcd4603adb1c9655cd4b4a7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The vertebrate Six1 and Six2 arose by gene duplication from the Drosophila sine oculis and have since diverged in their developmental expression patterns. Both genes are expressed in nephron progenitors of human fetal kidneys, and mutations in SIX1 o
Externí odkaz:
https://doaj.org/article/6d96adcb07114176b44b7858d0659540
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regener
Externí odkaz:
https://doaj.org/article/5cd0e2b5a4a4481b8d6ad089c0a2794f
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1006967 (2017)
The organ of Corti in the cochlea is a two-cell layered epithelium: one cell layer of mechanosensory hair cells that align into one row of inner and three rows of outer hair cells interdigitated with one cell layer of underlying supporting cells alon
Externí odkaz:
https://doaj.org/article/345e6aaff4e7482e8872ddbdee6b90c5
Autor:
Jianyun Yan, Lu Zhang, Jinshu Xu, Nishat Sultana, Jun Hu, Xiaoqiang Cai, Jun Li, Pin-Xian Xu, Chen-Leng Cai
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104503 (2014)
Proper formation of ureteral smooth muscle cells (SMCs) during embryogenesis is essential for ureter peristalsis that propels urine from the kidney to the bladder in mammals. Currently the molecular factors that regulate differentiation of ureteral m
Externí odkaz:
https://doaj.org/article/a7a68747a5c3480589eeab7e79bc4c6a
Autor:
Jun Li, Chunming Cheng, Jinshu Xu, Ting Zhang, Bengu Tokat, Georgia Dolios, Aarthi Ramakrishnan, Li Shen, Rong Wang, Pin-Xian Xu
Publikováno v:
Nucleic acids research. 50(18)
Eya1 is critical for establishing and maintaining nephron progenitor cells (NPCs). It belongs to a family of proteins called phosphatase-transcriptional activators but without intrinsic DNA-binding activity. However, the spectrum of the Eya1-centered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c36de262cf5187968086cfd8cbad0c7
https://pubmed.ncbi.nlm.nih.gov/36130284
https://pubmed.ncbi.nlm.nih.gov/36130284
Autor:
Jianqiang Ding, Pin-Xian Xu, Li Shen, Yong-Hwee E. Loh, Aarthi Ramakrishnan, Jun Li, Ting Zhang, Jinshu Xu, Bernd Fritzsch, Elaine Wong
Publikováno v:
Nucleic Acids Research
The transcription factor Six1 is essential for induction of sensory cell fate and formation of auditory sensory epithelium, but how it activates gene expression programs to generate distinct cell-types remains unknown. Here, we perform genome-wide ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3aec01bbde689a54c33ae24d9eefa9
https://doi.org/10.1093/nar/gkaa012
https://doi.org/10.1093/nar/gkaa012
Publikováno v:
J Am Soc Nephrol
Background Eya1 is a critical regulator of nephron progenitor cell specification and interacts with Six2 to promote NPC self-renewal. Haploinsufficiency of these genes causes kidney hypoplasia. However, how the Eya1-centered network operates remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5ba9a47f4ee8373fcf8ed855873d3a
https://pubmed.ncbi.nlm.nih.gov/34716237
https://pubmed.ncbi.nlm.nih.gov/34716237
Publikováno v:
Dev Dyn
BACKGROUND: Eya2 expression during mouse development has been studied by in situ hybridization and it has been shown to be involved skeletal muscle development and limb formation. Here, we generated Eya2 knockout (Eya2(−)) and a lacZ knockin report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02634ac7061558c21ca300e17d1f2f9b
https://europepmc.org/articles/PMC8438093/
https://europepmc.org/articles/PMC8438093/
Autor:
Ting Zhang, Huihui Jiang, Bernd Fritzsch, Jun Li, Li Shen, Aarthi Ramakrishnan, Pin-Xian Xu, Jinshu Xu
Publikováno v:
Proc Natl Acad Sci U S A
Specification of Sox2(+) proneurosensory progenitors within otic ectoderm is a prerequisite for the production of sensory cells and neurons for hearing. However, the underlying molecular mechanisms driving this lineage specification remain unknown. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb3c5e7a2dfe74875f2d0aea607c3f8
https://doi.org/10.1073/pnas.2025196118
https://doi.org/10.1073/pnas.2025196118