Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jinshan M. Chen"'
Autor:
Kanak Raina, Chris D. Forbes, Rebecca Stronk, Jonathan P. Rappi, Kyle J. Eastman, Samuel W. Gerritz, Xinheng Yu, Hao Li, Amit Bhardwaj, Mia Forgione, Abigail Hundt, Madeline P. King, Zoe M. Posner, Allison Denny, Andrew McGovern, David E. Puleo, Ethan Garvin, Rebekka Chenard, Nilesh Zaware, James J. Mousseau, Jennifer Macaluso, Michael Martin, Kyle Bassoli, Kelli Jones, Marco Garcia, Katia Howard, Levi M. Smith, Jinshan M. Chen, Cesar A. De Leon, John Hines, Katherine J. Kayser-Bricker, Craig M. Crews
While specific cell signaling pathway inhibitors have yielded great success in oncology, directly triggering cancer cell death is one of the great drug discovery challenges facing biomedical research in the era of precision oncology. Attempts to erad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23ae61c78302824016b90ccec8643f82
https://doi.org/10.1101/2023.01.01.522436
https://doi.org/10.1101/2023.01.01.522436
Autor:
Jennifer A. Young, Mark Edward Flanagan, Jinshan M. Chen, Carmen N. Garcia-Irizarry, R. Scott Obach, Brandon P. Schuff, Jeremy T. Starr, Upendra P. Dahal, Daniel P. Uccello, Adam M. Gilbert
Publikováno v:
MedChemComm. 7:864-872
Covalent drugs contain a reactive electrophilic moiety or covalent reactive group (CRG), which forms an irreversible bond between the drug and a biological target. Consequently, the intrinsic reactivity of the CRG is an important consideration in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef76804ac11f6e5b90506d0944cbc187
https://doi.org/10.1039/c6md00017g
https://doi.org/10.1039/c6md00017g
Autor:
Daniel P. Uccello, Jeremy T. Starr, Matthew Merrill Hayward, R. Scott Obach, Mark C. Noe, Adam M. Gilbert, Justin I. Montgomery, Mark Edward Flanagan, Veerabahu Shanmugasundaram, Dennis P. Anderson, Ann Aulabaugh, Ye Che, Matthew Frank Brown, Michael J. Shapiro, Chao Li, Tim F. Ryder, Stacey R. Oppenheimer, Laurence Philippe, Gregory S. Walker, Yan Wu, Brandon P. Schuff, Joseph A. Abramite, Jinshan M. Chen, Justin G. Stroh, Upendra P. Dahal
Publikováno v:
Journal of Medicinal Chemistry. 57:10072-10079
Interest in drugs that covalently modify their target is driven by the desire for enhanced efficacy that can result from the silencing of enzymatic activity until protein resynthesis can occur, along with the potential for increased selectivity by ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63f9459b6f272dc5eca40673816be92
https://doi.org/10.1021/jm501412a
https://doi.org/10.1021/jm501412a
Autor:
Jean S. Beebe, William M. Hungerford, Nandini Chaturbhai Patel, Heather N. Frost, Susan Deborah Lagreca, Cathy Soderstrom, Shefali Kakar, Doug Savage, Matthew David Wessel, Matthew A. Marx, Merin Boehm, Thompson Carl Brian, Jinshan M. Chen, Connell Richard D, Nandell F. Keene, Elizabeth Knauth, Gary Borzillo, Aaron Kanter, Yong Lu, Joel Morris, Martin A. Berliner, Patrick Vincent, Bruce D. Cohen, George T. Tkalcevic, Joel T. Arcari, Deborah A. Gordon, James J. Valentine, Tracey Clark, Louis Martinez-Alsina, Vincent Bernardo, Felix Vajdos, Norma Jacqueline Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3059-3063
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4094fb50746e9612e49cef7a5bc7bf6
https://doi.org/10.1016/j.bmcl.2013.03.012
https://doi.org/10.1016/j.bmcl.2013.03.012
Autor:
Li Xing, Jane M. Withka, Guoyun Bai, Mark E. Bunnage, Bruce Allen Lefker, Leslie Anthony Dakin, Sheng Tan, Shenping Liu, Mary Ellen Banker, Parag Sahasrabudhe, Ariamala Gopalsamy, Atli Thorarensen, Hua Xu, Jennifer A. Young, Joerg Bussenius, Boris A. Chrunyk, Jinshan M. Chen, Kieran F. Geoghegan, Stephen W. Wright, Suman Shanker, Jeremy T. Starr, Paul Balbo, Xiayang Qiu, Zuojun Guo, Wei Li, Lyn H. Jones, Fabien Vincent, Lise R. Hoth
Publikováno v:
Scientific Reports
Interleukin-17A (IL-17A) is a principal driver of multiple inflammatory and immune disorders. Antibodies that neutralize IL-17A or its receptor (IL-17RA) deliver efficacy in autoimmune diseases, but no small-molecule IL-17A antagonists have yet progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d84fd35679a6248c177be87226d5378
Autor:
Lisa Mullins, Daniel P. Uccello, Justin I. Montgomery, Ye Che, John P. O'Donnell, Mark S. Plummer, Joseph A. Abramite, Seung Won Chung, Loren M. Price, Mark C. Noe, Laura A. McAllister, Rose Barham, Mark J. Mitton-Fry, Andrew P. Tomaras, Usa Reilly, Matthew Frank Brown, Jinshan M. Chen, Joseph Penzien, Carol A. Menard, Veerabahu Shanmugasundaram, Robert M. Oliver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6832-6838
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the oute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698632622184881fc9d9e040335da17
https://doi.org/10.1016/j.bmcl.2012.09.058
https://doi.org/10.1016/j.bmcl.2012.09.058