Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jinsai Shang"'
Autor:
Qi Yang, Bao Xue, Fengjiang Liu, Yongzhi Lu, Jielin Tang, Mengrong Yan, Qiong Wu, Ruyi Chen, Anqi Zhou, Lijie Liu, Junjun Liu, Changbin Qu, Qingxin Wu, Muqing Fu, Jiayi Zhong, Jianwei Dong, Sijie Chen, Fan Wang, Yuan Zhou, Jie Zheng, Wei Peng, Jinsai Shang, Xinwen Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using high-throughput antiviral screen
Externí odkaz:
https://doaj.org/article/01b39b7fef754488ac712a26b84c51be
Autor:
Jinsai Shang, Douglas J Kojetin
Publikováno v:
eLife, Vol 13 (2024)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor transcription factor that regulates gene expression programs in response to ligand binding. Endogenous and synthetic ligands, including covalent antagonist inhibitors GW9
Externí odkaz:
https://doaj.org/article/fb8838a62f4b4e72936073ad314cfa87
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 190 (2024)
Lung cancer is one of the most lethal malignancies worldwide. Peroxisome proliferator-activated receptor gamma (PPARγ, NR1C3) is a ligand-activated transcriptional factor that governs the expression of genes involved in glucolipid metabolism, energy
Externí odkaz:
https://doaj.org/article/4de49547ebec40fba46858060180e0ac
Publikováno v:
eLife, Vol 12 (2023)
Small molecule compounds that activate transcription of Nurr1-retinoid X receptor alpha (RXRα) (NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of neurodegenerative disorders, but function through poorly understood mechani
Externí odkaz:
https://doaj.org/article/63d92d0c1fcc4fdfb65d10b132435773
Autor:
Jinsai Shang, Sarah A. Mosure, Jie Zheng, Richard Brust, Jared Bass, Ashley Nichols, Laura A. Solt, Patrick R. Griffin, Douglas J. Kojetin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome prolifera
Externí odkaz:
https://doaj.org/article/9d32e7db99b24a56b787934b31a56130
Autor:
Richard Brust, Jinsai Shang, Jakob Fuhrmann, Sarah A. Mosure, Jared Bass, Andrew Cano, Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Anne-Laure Blayo, Patrick R. Griffin, Theodore M. Kamenecka, Travis S. Hughes, Douglas J. Kojetin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a target for insulin sensitizing drugs. Here the authors combine NMR, X-ray crystallography and MD simulations and report a structural mechanism for eliciting PPARγ inverse agonism, where
Externí odkaz:
https://doaj.org/article/83045b413545471dafc949ec4db32b64
Autor:
Ian M. Chrisman, Michelle D. Nemetchek, Ian Mitchelle S. de Vera, Jinsai Shang, Zahra Heidari, Yanan Long, Hermes Reyes-Caballero, Rodrigo Galindo-Murillo, Thomas E. Cheatham, Anne-Laure Blayo, Youseung Shin, Jakob Fuhrmann, Patrick R. Griffin, Theodore M. Kamenecka, Douglas J. Kojetin, Travis S. Hughes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor. Here the authors provide insights into PPARγ activation by combining fluorine (19F) NMR and molecular dynamics simulations to characterize the nuclear receptor conforma
Externí odkaz:
https://doaj.org/article/85e8ea413a844fe895eaaf28a09a3b89
Autor:
Mohammed Amir, Sweena Chaudhari, Ran Wang, Sean Campbell, Sarah A. Mosure, Laura B. Chopp, Qun Lu, Jinsai Shang, Oliver B. Pelletier, Yuanjun He, Christelle Doebelin, Michael D. Cameron, Douglas J. Kojetin, Theodore M. Kamenecka, Laura A. Solt
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3733-3749.e8 (2018)
Summary: RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH17) cell development. However, the cell-intrinsic mechanisms that negatively regulate TH17 cell development and autoimmunity remain poorly understood.
Externí odkaz:
https://doaj.org/article/5543335c68ab4cb7b10b6c0611e56c76
Autor:
Jinsai Shang, Richard Brust, Sarah A Mosure, Jared Bass, Paola Munoz-Tello, Hua Lin, Travis S Hughes, Miru Tang, Qingfeng Ge, Theodore M Kamenekca, Douglas J Kojetin
Publikováno v:
eLife, Vol 7 (2018)
Crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) have revealed overlapping binding modes for synthetic and natural/endogenous ligands, indicating competition for the orthosteric pocket. Here we show that cobinding of a
Externí odkaz:
https://doaj.org/article/a02167cd994848e18bdd02c3743d1314
Autor:
Xiangsheng Huang, HaJeung Park, Deborah Schady, Alexander Rodriguez-Palacios, Guohui Wang, Mei Lan Chen, Yujin Liu, Casey T. Weaver, Douglas J. Kojetin, Amber Eliason, David D. Moore, Jinsai Shang, Matthew E. Pipkin, Huitian Diao, Blake Frey, Laura A. Solt, Mark S. Sundrud, Courtney Hegner, Hongtao Wang, Sarah A. Mosure
Publikováno v:
Nature
Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine1. As detergents, bile acids can cause toxicity and inflammation in enterohepatic ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f9859e3dc924c36f9f51ca55a06332
https://doi.org/10.1038/s41586-021-03421-6
https://doi.org/10.1038/s41586-021-03421-6