Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jinqiu Zhu"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The endoplasmic reticulum (ER) and lysosome are central to cellular stress responses, but it is unclear how ER stress is signaled to lysosomes. Here the authors show that ER stress activates chaperone-mediated autophagy (CMA) via direct phosphorylati
Externí odkaz:
https://doaj.org/article/fe92931b0c6143268e9973c526173436
Autor:
Bart Heldreth, Thomas J. Slaga, Daniel C. Liebler, Ronald C. Shank, Ivan J. Boyer, Jinqiu Zhu, Curtis D. Klaassen, Ronald A. Hill, James G. Marks, Wilma F. Bergfeld, Paul W. Snyder, Donald V. Belsito, Wilbur Johnson
Publikováno v:
International journal of toxicology. 39(3_suppl)
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride), which functions as a preservative in cosmetic products. The Panel reviewed relevant data relating to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef61f5aad978c0e289daed94fc84a73
https://pubmed.ncbi.nlm.nih.gov/33203268
https://pubmed.ncbi.nlm.nih.gov/33203268
Autor:
Bart Heldreth, Thomas J. Slaga, Paul W. Snyder, Ronald A. Hill, Priya Cherian, Daniel C. Liebler, Donald V. Belsito, Curtis D. Klaassen, Wilma F. Bergfeld, Ronald C. Shank, James G. Marks, Jinqiu Zhu
Publikováno v:
International journal of toxicology. 39(1_suppl)
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 21 parabens as preservatives in cosmetic products. All of these ingredients are reported to function in cosmetics as preservatives; however, 5 are reported to also functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33628e6d4f86adfa57c4b55ad6cb2f5d
https://pubmed.ncbi.nlm.nih.gov/32723119
https://pubmed.ncbi.nlm.nih.gov/32723119
Autor:
Jie Wang, Xushen Chen, Jinqiu Zhu, Michael J. Buck, Maria Tsompana, Daniel Gaile, Xuefeng Ren
Publikováno v:
Carcinogenesis. 38:378-390
Our previous studies have shown that chronic exposure to low doses of monomethylarsonous acid (MMAIII) causes global histone acetylation dysregulation in urothelial cells (UROtsa cells) during the course of malignant transformation. To reveal the rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be75a1935311f4a87fdcb040631f23c
https://doi.org/10.1093/carcin/bgx011
https://doi.org/10.1093/carcin/bgx011
Autor:
Xushen Chen, Xiaojiang Tang, Diana S. Aga, James R. Olson, Jinqiu Zhu, Wei Hu, Nina Zheng, Xuefeng Ren, Wei Sun, Yichen Ge
Publikováno v:
Chemical research in toxicology. 32(8)
Cisplatin is a platinum-based chemotherapeutic drug widely used in the treatment of various cancers such as testicular, ovarian, lung, bladder, and cervical cancers. However, its use and the dosage range applied have been limited by severe side effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468fb177a1074f05a1b9dc2e26007e63
https://pubmed.ncbi.nlm.nih.gov/31240907
https://pubmed.ncbi.nlm.nih.gov/31240907
Autor:
Zhiyue Liu, Xushen Chen, Jing Nie, Peilin Xu, Xiaojuan Guo, Jinqiu Zhu, Diana S. Aga, Martyn T. Smith, Luoping Zhang, Xiaoyan Yan, Xuefeng Ren, Hongmei Wu, Guangyun Mao, Ping He
Publikováno v:
Toxicological Sciences. 155:124-134
Chronic arsenic exposure via drinking water has become a worldwide public health concern. In humans, inorganic arsenic (iAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) mainly mediated by arsenic (+3 oxidation state)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33c0acff0c5c64a42d41fd30064b8e3
https://doi.org/10.1093/toxsci/kfw181
https://doi.org/10.1093/toxsci/kfw181
Arsenic is a known potent risk factor for bladder cancer. Increasing evidence suggests that epigenetic alterations, e.g., DNA methylation and histones posttranslational modifications (PTMs), contribute to arsenic carcinogenesis. Our previous studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d0b8b10198af1ccbc5902a7f496aab
https://europepmc.org/articles/PMC6090552/
https://europepmc.org/articles/PMC6090552/
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 76:76-82
Introduction High-throughput loss-of-function genetic screening tools in yeast or other model systems except in mammalian cells have been implemented to study human susceptibility to chemical toxicity. Here, we employed a newly developed human haploi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867e65399a1e09e4398120a612bc57b0
https://doi.org/10.1016/j.vascn.2015.08.154
https://doi.org/10.1016/j.vascn.2015.08.154
Publikováno v:
Acta Diabetologica. 52:959-969
Advanced glycation end products (AGEs) have been implicated in pulmonary and renal fibrosis. Herein, we investigated whether AGEs are associated with liver fibrosis and examined the underlying mechanism by focusing on hepatic stellate cell (HSC) acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72162f0d428a2d7d7fb94aa1e912e257
https://doi.org/10.1007/s00592-015-0763-7
https://doi.org/10.1007/s00592-015-0763-7
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Endoplasmic reticulum (ER) and lysosomes coordinate a network of key cellular processes including unfolded protein response (UPR) and autophagy in response to stress. How ER stress is signaled to lysosomes remains elusive. Here we find that ER distur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8c60577819cfdd59c556e1c2420ce8
https://doi.org/10.1038/s41467-017-01609-x
https://doi.org/10.1038/s41467-017-01609-x