Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jinqiao, Wan"'
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions
Externí odkaz:
https://doaj.org/article/bba575b98c5347daaebc8aca8d09ed71
Autor:
Qiuxia Chen, Chuan Liu, Wei Wang, Xiaoyun Meng, Xuemin Cheng, Xianyang Li, Longying Cai, Linfu Luo, Xu He, Huan Qu, Jing Luo, Hong Wei, Sen Gao, Guansai Liu, Jinqiao Wan, David I. Israel, Jin Li, Dengfeng Dou
Publikováno v:
ACS Chemical Biology. 18:25-33
The proteolysis targeting chimera (PROTAC) strategy results in the down-regulation of unwanted protein(s) for disease treatment. In the PROTAC process, a heterobifunctional degrader forms a ternary complex with a target protein of interest (POI) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8c796851f56d9442966a69a2d72203
https://doi.org/10.1021/acschembio.2c00797
https://doi.org/10.1021/acschembio.2c00797
Autor:
Yurong Shen, Guanyu Yang, Wei Huang, Alex Shaginian, Qian Lin, Jinqiao Wan, Jin Li, Yun Deng, Guansai Liu
Publikováno v:
Organic Letters. 24:2650-2654
Herein, we report an on-DNA photoredox-mediated deaminative alkylation method for diversifying DNA-tagged acrylamide substrate with amine-derived radicals. The radicals can be conveniently generated from sterically hindered primary amines, and the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd4f60cce946af02ef12786c174cc23
https://doi.org/10.1021/acs.orglett.2c00697
https://doi.org/10.1021/acs.orglett.2c00697
Autor:
Huiyong Ma, James B. Murray, Huadong Luo, Xuemin Cheng, Qiuxia Chen, Chao Song, Cong Duan, Ping Tan, Lifang Zhang, Jian Liu, Barry A. Morgan, Jin Li, Jinqiao Wan, Lisa M. Baker, William Finnie, Lucie Guetzoyan, Richard Harris, Nicole Hendrickson, Natalia Matassova, Heather Simmonite, Julia Smith, Roderick E. Hubbard, Guansai Liu
Publikováno v:
RSC Medicinal Chemistry. 13:1341-1349
We describe a novel approach for screening fragments against a protein that combines the sensitivity of DNA-encoded library technology with the ability of fragments to explore what will bind. Each of the members of the library consists of a fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769d6828e3d693dc0b393f77ff842ff8
https://doi.org/10.1039/d2md00197g
https://doi.org/10.1039/d2md00197g
Publikováno v:
Organic Letters. 23:3486-3490
A highly efficient approach to C(sp3)-C(sp3) bond construction via on-DNA photoredox catalysis between on-DNA alkenes and N-aryl tertiary amines was developed. The methodology demonstrated 55%-95% conversions without obvious DNA damage, as seen by qP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c85393eb50b0126f386b6644fcdb17fe
https://doi.org/10.1021/acs.orglett.1c00924
https://doi.org/10.1021/acs.orglett.1c00924
Autor:
Dominik K. Kölmel, Jinqiao Wan, Barry A. Morgan, Hongyao Zhu, Mark Edward Flanagan, Sylvie K. Sakata, Anthony R. Harris
Publikováno v:
The Chemical Record. 21:616-630
This Personal Account describes the authors' foray into DNA-encoded libraries. The article addresses several key aspects of this hit generation technology, from the development of new synthetic methodology to the subsequent conception, design, and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10728fc7eb0789d60bc42ea8e82521f4
https://doi.org/10.1002/tcr.202000148
https://doi.org/10.1002/tcr.202000148
Publikováno v:
Biochemical and Biophysical Research Communications. 533:249-255
DEL selections are binding assays conducted with mixtures of chemically diverse DNA-tagged ligands and a screening target. DEL selections use DNA sequence counts to measure target binding, where ideally higher affinity ligands will have higher counts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07270831e011ceb293b086bffc365b07
https://doi.org/10.1016/j.bbrc.2020.04.029
https://doi.org/10.1016/j.bbrc.2020.04.029
Publikováno v:
Organic Letters. 22:6277-6282
Indazolone cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. In this report, a mild and efficient approach to 2-su...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8772d35b19a18d8641ec8e1dac64d5b6
https://doi.org/10.1021/acs.orglett.0c02032
https://doi.org/10.1021/acs.orglett.0c02032
Autor:
Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0b93599ae79500f98919ddfa6e48aa
https://doi.org/10.1021/acsmedchemlett.0c00029
https://doi.org/10.1021/acsmedchemlett.0c00029
Autor:
Dillon T. Flood, Xuejing Zhang, Xiang Fu, Zhenxiang Zhao, Shota Asai, Brittany B. Sanchez, Emily J. Sturgell, Julien C. Vantourout, Paul Richardson, Mark E. Flanagan, David W. Piotrowski, Dominik K. Kölmel, Jinqiao Wan, Mei‐Hsuan Tsai, Jason S. Chen, Phil S. Baran, Philip E. Dawson
Publikováno v:
Angewandte Chemie. 132:7447-7453
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ea26b46c081310a834a2d3faf385e4a
https://doi.org/10.1002/ange.201915493
https://doi.org/10.1002/ange.201915493