Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jinping, Pang"'
Autor:
Xueping Hu, Jinping Pang, Jintu Zhang, Chao Shen, Xin Chai, Ercheng Wang, Haiyi Chen, Xuwen Wang, Mojie Duan, Weitao Fu, Lei Xu, Yu Kang, Dan Li, Hongguang Xia, Tingjun Hou
Publikováno v:
Advanced Science, Vol 9, Iss 3, Pp n/a-n/a (2022)
Abstract Binding of different ligands to glucocorticoid receptor (GR) may induce different conformational changes and even trigger completely opposite biological functions. To understand the allosteric communication within the GR ligand binding domai
Externí odkaz:
https://doaj.org/article/983e9ea946634a7692f9406784185741
Autor:
Wenfang Zhou, Mojie Duan, Weitao Fu, Jinping Pang, Qin Tang, Huiyong Sun, Lei Xu, Shan Chang, Dan Li, Tingjun Hou
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 16, Iss 6, Pp 416-427 (2018)
Androgen receptor (AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the co
Externí odkaz:
https://doaj.org/article/aa671940c5c34c26b05f3e2792f75ec6
Autor:
Dan Li, Xiaodong Bao, Jinping Pang, Xueping Hu, Longling Wang, Jiajia Wang, Zhaoxu Yang, Lei Xu, Siyu Wang, Qinjie Weng, Sunliang Cui, Tingjun Hou
Publikováno v:
Journal of Medicinal Chemistry. 65:15710-15724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8335a312d95f7f22c49120dabc10c06
https://doi.org/10.1021/acs.jmedchem.2c01082
https://doi.org/10.1021/acs.jmedchem.2c01082
Autor:
Xin Chai, Huiyong Sun, Wenfang Zhou, Changwei Chen, Luhu Shan, Yuhui Yang, Junzhao He, Jinping Pang, Liu Yang, Xinyue Wang, Sunliang Cui, Yaqin Fu, Xiaohong Xu, Lei Xu, Xiaojun Yao, Dan Li, Tingjun Hou
Publikováno v:
Journal of Medicinal Chemistry. 65:2507-2521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc26bb38c9f8641ef0366de40eafadde
https://doi.org/10.1021/acs.jmedchem.1c01938
https://doi.org/10.1021/acs.jmedchem.1c01938
Autor:
Qing Tang, Mojie Duan, Luhu Shan, Xuwen Wang, Yi-Xuan Lei, Weitao Fu, Xin Chai, Jianing Liao, Zhou Gong, Xiaohong Xu, Tingjun Hou, Dan Li, Minkui Zhang, Chun Tang, Jinping Pang, Rong Sheng
Publikováno v:
Journal of Medicinal Chemistry. 64:17221-17238
Androgen receptor (AR) has proved to be a vital drug target for treating prostate cancer. Here, we reported the discovery of a novel AR antagonist 92 targeting the AR ligand-binding pocket, but distinct from the marketed drug enzalutamide (Enz), 92 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ea50e6057d00771c5aa8aa56b94b5a
https://doi.org/10.1021/acs.jmedchem.1c01287
https://doi.org/10.1021/acs.jmedchem.1c01287
Publikováno v:
Journal of Chemical Information and Modeling. 62:5233-5245
As a major drug target for anti-inflammatory therapy, the glucocorticoid receptor (GR) regulates a wide range of physiological processes through transactivation (TA) or transrepression. GR TA is involved in many adverse effects of GR-targeting drugs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a270b13d36c4db7aaf486e39a57f8c5f
https://doi.org/10.1021/acs.jcim.1c00150
https://doi.org/10.1021/acs.jcim.1c00150
Autor:
Xueping Hu, Tingjun Hou, Xiaohong Xu, Lei Xu, Dan Li, Li Xiao, Ying Shao, Yunxia Wang, Dan-yan Zhu, Jinping Pang, Chao Shen, Wenfang Zhou, Xin Chai, Feng Zhu, Luhu Shan
Publikováno v:
Acta Pharmacol Sin
Background and Purpose: Androgen receptor (AR), a ligand-activated transcription factor, is a master regulator in the development and progress of prostate cancer (PCa). A major challenge for the clinically used AR antagonists is the rapid emergence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06034a5211db44638ab7323211dc418
https://doi.org/10.1038/s41401-021-00632-5
https://doi.org/10.1038/s41401-021-00632-5
Autor:
Xin Chai, Gaoqi Weng, Junbo Gao, Tingjun Hou, Yu Kang, Dan Li, Hongyan Du, Jinping Pang, Junjie Ding, Dong-Sheng Cao
Publikováno v:
Nucleic Acids Research
Inhibitors that form covalent bonds with their targets have traditionally been considered highly adventurous due to their potential off-target effects and toxicity concerns. However, with the clinical validation and approval of many covalent inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b85245046099509beb95136a1bbd11
https://doi.org/10.1093/nar/gkaa876
https://doi.org/10.1093/nar/gkaa876
Publikováno v:
Drug Discovery Today. 25:1453-1461
The androgen receptor is a ligand-dependent transcriptional factor and an essential therapeutic target for prostate cancer. Competitive binding of antagonists to the androgen receptor can alleviate aberrant activation of the androgen receptor in pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542048a41196b4f9a6d45892085e458d
https://doi.org/10.1016/j.drudis.2020.04.004
https://doi.org/10.1016/j.drudis.2020.04.004
Autor:
Xin, Chai, Huiyong, Sun, Wenfang, Zhou, Changwei, Chen, Luhu, Shan, Yuhui, Yang, Junzhao, He, Jinping, Pang, Liu, Yang, Xinyue, Wang, Sunliang, Cui, Yaqin, Fu, Xiaohong, Xu, Lei, Xu, Xiaojun, Yao, Dan, Li, Tingjun, Hou
Publikováno v:
Journal of medicinal chemistry. 65(3)
Androgen receptor (AR) antagonists have been widely used for the treatment of prostate cancer (PCa). As a link between the AR and its transcriptional function, the activation function 2 (AF2) region has recently been revealed as a novel targeting sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1999233bc8b4e0b14e1d516afa089cab
https://pubmed.ncbi.nlm.nih.gov/35077161
https://pubmed.ncbi.nlm.nih.gov/35077161