Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jinnan Xiang"'
A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche
Autor:
Jinnan Xiang, Jigang Guo, Shaoyang Zhang, Hongguang Wu, Ye-Guang Chen, Junping Wang, Baojie Li, Huijuan Liu
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background The nutrient-absorbing villi of small intestines are renewed and repaired by intestinal stem cells (ISCs), which reside in a well-organized crypt structure. Genetic studies have shown that Wnt molecules secreted by telocytes, Gli1
Externí odkaz:
https://doaj.org/article/f6f8689f796447e3bb47d4a24365f0aa
Autor:
Dan He, Hongguang Wu, Jinnan Xiang, Xinsen Ruan, Peike Peng, Yuanyuan Ruan, Ye-Guang Chen, Yibin Wang, Qiang Yu, Hongbing Zhang, Samy L. Habib, Ronald A. De Pinho, Huijuan Liu, Baojie Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be amelio
Externí odkaz:
https://doaj.org/article/2b693f1be87a4d81b68d6deb696ecba7
Autor:
Jinnan Xiang, Yiqun Zhang, Dandan Bao, Na Cao, Xin Zhang, Ping Li, Shoutao Qiu, Jigang Guo, Dan He, Baojie Li, Liqing Yao, Huijuan Liu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The gastrointestinal tract is responsible for food digestion and absorption. The muscularis propria propels the foodstuff through the GI tract and defects in intestine motility may cause obstruction disorders. Our present genetic studies ide
Externí odkaz:
https://doaj.org/article/ef9cd61f8ffb4cf0936115d01b4c0c06
Autor:
Huijuan Liu, Ping Li, Shaoyang Zhang, Jinnan Xiang, Ruichen Yang, Jiajia Liu, Md Shafiquzzaman, Soma Biswas, Zhanying Wei, Zhenlin Zhang, Xin Zhou, Feng Yin, Yangli Xie, Stephen P. Goff, Lin Chen, Baojie Li
Publikováno v:
Nature Genetics. 54:1946-1958
Specialized connective tissues, including bone and adipose tissues, control various physiological activities, including mineral and energy homeostasis. However, the identity of stem cells maintaining these tissues throughout adulthood remains elusive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cbe3f12e00c4c41a67d2dbd70f5a97
https://doi.org/10.1038/s41588-022-01227-4
https://doi.org/10.1038/s41588-022-01227-4
Autor:
Ronald A. De Pinho, Yuanyuan Ruan, Samy L. Habib, Jinnan Xiang, Qiang Yu, Yibin Wang, Xinsen Ruan, Ye-Guang Chen, Dan He, Peike Peng, Hongbing Zhang, Huijuan Liu, Hongguang Wu, Baojie Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear. Here, we show that aging-caused intestinal villus structural and functional decline is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96f88339b9570381ddcd131017d56a7
https://doaj.org/article/2b693f1be87a4d81b68d6deb696ecba7
https://doaj.org/article/2b693f1be87a4d81b68d6deb696ecba7
Autor:
Hongguang Wu, Liang Gao, Zhuo Wang, Baojie Li, Jinnan Xiang, Huijuan Liu, Yizhou Xu, Ye-Guang Chen, Gang Shu, Zhengting Wang, Huasheng Zhang, Shuxiang Yu, Lei Shen, Qian Yu, Tianyu Zhang, Shaoyang Zhang, Lu Shen
Publikováno v:
Science Translational Medicine. 13
Inflammatory bowel disease (IBD) affects 0.3% of the global population, yet the etiology remains poorly understood. Anti-inflammation therapy has shown great success, but only 60% of patients with IBD benefit from it, indicating that new targets are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a40ac3eec92e888c347fdf79346f3ae
https://doi.org/10.1126/scitranslmed.abb5071
https://doi.org/10.1126/scitranslmed.abb5071
Autor:
Ruiyao Xu, Shentian Li, Weidong Li, Baojie Li, Andrew J. Brown, Shuxiang Yu, Hongshang Chu, Hongyuan Yang, Yuhong Xu, Shaoyang Zhang, Dengshun Miao, Huijuan Liu, Soma Biswas, Jinnan Xiang
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(4)
Obesity is common in the middle aged population and it increases the risks of diabetes, cardiovascular diseases, certain cancers, and dementia. Yet, its etiology remains incompletely understood. Here, we show that ectopic expression of HB-EGF, an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124d6b3688d59ae55e8d11ac77eee850
https://pubmed.ncbi.nlm.nih.gov/33715219
https://pubmed.ncbi.nlm.nih.gov/33715219
Autor:
Ping Li, Dan He, Baojie Li, Li-Qing Yao, Yiqun Zhang, Na Cao, Xin Zhang, Jinnan Xiang, Dandan Bao, Shoutao Qiu, Jigang Guo, Huijuan Liu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
The gastrointestinal tract is responsible for food digestion and absorption. The muscularis propria propels the foodstuff through the GI tract and defects in intestine motility may cause obstruction disorders. Our present genetic studies identified n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f490c117174589cc99fd9854e11eed8
https://doi.org/10.1038/s41598-017-03569-0
https://doi.org/10.1038/s41598-017-03569-0
Publikováno v:
Scientific Reports
Ect2 is a BRCT-containing guanidine exchange factor for Rho GTPases. It is essential for cytokinesis and is also involved in tumorigenesis. Since most BRCT-containing proteins are involved in DNA damage response and/or DNA repair, we tested whether E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ee5908be7e610d7f22d41a6a58a45a
https://pubmed.ncbi.nlm.nih.gov/27074761
https://pubmed.ncbi.nlm.nih.gov/27074761
Autor:
Jinnan Xiang, Shaoyang Zhang, Ruiyao Xu, Hongshang Chu, Biswas, Soma, Shuxiang Yu, Dengshun Miao, Weidong Li, Shentian Li, Brown, Andrew J., Hongyuan Yang, Yuhong Xu, Baojie Li, Huijuan Liu
Publikováno v:
FASEB Journal; Apr2021, Vol. 35 Issue 4, p1-1, 1p