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Akademický článek

Nrf2−/− regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure

Autor: Mengjie Wu, Menghui Jiang, Hao Ding, Siying Tang, Daochuan Li, Jingbo Pi, Rong Zhang, Wen Chen, Rui Chen, Yuxin Zheng, Jinmei Piao

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Cytochrome P450 (CYP450) can mediate fine particulate matter (PM2.5) exposure leading to lung injury. Nuclear factor E2-related factor 2 (Nrf2) can regulate CYP450 expression; however, the mechanism by which Nrf2−/− (KO) regulates CYP450 expressi

Externí odkaz: https://doaj.org/article/77ed1637a2a34aef8dc1cd314fd389cb

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Akademický článek

GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation

Autor: Siying Tang, Daochuan Li, Hao Ding, Menghui Jiang, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Rui Chen, Yuxin Zheng, Jinmei Piao

Publikováno v: Ecotoxicology and Environmental Safety, Vol 232, Iss , Pp 113248- (2022)

Exposure to fine particulate matter (PM2.5) could damage multiple organs and systems. Recent epidemiological studies have shown that PM2.5 can disrupt dynamic balance of thyroid hormone (TH). However, the underlying mechanism by which PM2.5 interfere

Externí odkaz: https://doaj.org/article/759e7643eaef47d78cf06d0f4d080abc

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Akademický článek

Effects of Real-Ambient PM2.5 Exposure on Lung Damage Modulated by Nrf2−/−

Autor: Hao Ding, Menghui Jiang, Daochuan Li, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Jingbo Pi, Rui Chen, Lianhua Cui, Yuxin Zheng, Jinmei Piao

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Previous studies have shown that long-term exposure to fine particulate matter (PM2.5) increases the morbidity and mortality of pulmonary diseases such as asthma, chronic obstructive pulmonary disease and pulmonary emphysema. Oxidative stress and inf

Externí odkaz: https://doaj.org/article/1c3b1fd3057b4ba8a8f48c87aa31e251

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