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Akademický článek

Transcription factor network analysis based on single cell RNA-seq identifies that Trichostatin-a reverses docetaxel resistance in prostate Cancer

Autor: Patricia M. Schnepp, Aqila Ahmed, June Escara-Wilke, Jinlu Dai, Greg Shelley, Jill Keller, Atsushi Mizokami, Evan T. Keller

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)

Abstract Background Overcoming drug resistance is critical for increasing the survival rate of prostate cancer (PCa). Docetaxel is the first cytotoxic chemotherapeutical approved for treatment of PCa. However, 99% of PCa patients will develop resista

Externí odkaz: https://doaj.org/article/d20bcba51bc24959b570b2ddf87858d9

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Akademický článek

Pheno-SELEX: Engineering Anti-Metastatic Aptamers through Targeting the Invasive Phenotype Using Systemic Evolution of Ligands by Exponential Enrichment

Autor: Greg Shelley, Jinlu Dai, Jill M. Keller, Evan T. Keller

Publikováno v: Bioengineering, Vol 8, Iss 12, p 212 (2021)

Multiple methods (e.g., small molecules and antibodies) have been engineered to target specific proteins and signaling pathways in cancer. However, many mediators of the cancer phenotype are unknown and the ability to target these phenotypes would he

Externí odkaz: https://doaj.org/article/4a9f7ddffa154f15acc832d5e8a4ecef

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Akademický článek

Immune mediators in the tumor microenvironment of prostate cancer

Autor: Jinlu Dai, Yi Lu, Hernan Roca, Jill M. Keller, Jian Zhang, Laurie K. McCauley, Evan T. Keller

Publikováno v: Chinese Journal of Cancer, Vol 36, Iss 1, Pp 1-8 (2017)

Abstract Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor origi

Externí odkaz: https://doaj.org/article/a9a9a294caed4bd08663813cde6320fe

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Akademický článek

Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling

Autor: Wenchu Wang, Lihui Wang, Atsushi Mizokami, Junlin Shi, Chunlin Zou, Jinlu Dai, Evan T. Keller, Yi Lu, Jian Zhang

Publikováno v: Chinese Journal of Cancer, Vol 36, Iss 1, Pp 1-13 (2017)

Abstract Background The chemoresistance of prostate cancer (PCa) is invariably associated with the aggressiveness and metastasis of this disease. New emerging evidence indicates that the epithelial-to-mesenchymal transition (EMT) may play pivotal rol

Externí odkaz: https://doaj.org/article/520d84e0733442dfb904a51097f1d1bb

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Akademický článek

Prevalence of Prostate Cancer Metastases after Intravenous Inoculation Provides Clues into the Molecular Basis of Dormancy in the Bone Marrow Microenvironment

Autor: Younghun Jung, Yusuke Shiozawa, Jingcheng Wang, Natalie McGregor, Jinlu Dai, Serk In Park, Janice E. Berry, Aaron M. Havens, Jeena Joseph, Jin Koo Kim, Lalit Patel, Peter Carmeliet, Stephanie Daignault, Evan T. Keller, Laurie K. McCauley, Kenneth J. Pienta, Russell S. Taichman

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 5, Pp 429-439 (2012)

Bone is the preferred metastasis site of advanced prostate cancer (PCa). Using an in vivo murine model of human PCa cell metastasis to bone, we noted that the majority of animals that develop skeletal metastasis have either spinal lesions or lesions

Externí odkaz: https://doaj.org/article/3ab33eedfe664f0b80bdde5459a8b390

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Akademický článek

Pheno-SELEX: Engineering Anti-Metastatic Aptamers through Targeting the Invasive Phenotype Using Systemic Evolution of Ligands by Exponential Enrichment.

Autor: Shelley, Greg¹ gregsh@med.umich.edu, Jinlu Dai¹ jldai@med.umich.edu, Keller, Jill M.² jmurtha@umich.edu, Keller, Evan T.^1,3,4 etkeller@med.umich.edu

Publikováno v: Bioengineering (Basel). Dec2021, Vol. 8 Issue 12, p1-14. 14p.

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