Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jinle Tang"'
Autor:
Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Wenning Zhu, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism o
Externí odkaz:
https://doaj.org/article/e0b510d04f0846f9afbec3f3b04bc27e
Autor:
Jinle Tang, Yi Zheng, Lipei Fang, Juanli Pan, Yaoqi Zhou, Yunxia Xu, Wei Xu, Yanhong Ma, Jian Zhan, Yingshou Lei, Danting Zhang, Xin Chen, Ke Chen, Bao Zhang
Publikováno v:
International Journal of Biological Macromolecules
COVID-19 is a disease caused by SARS-CoV-2, which has led to more than 4 million deaths worldwide. As a result, there is a worldwide effort to develop specific drugs for targeting COVID-19. Papain-like protease (PLpro) is an attractive drug target be
Autor:
Dan Cao, Ziyang Fu, Jinle Tang, Yuxian Xiong, Yong Juan Zhao, Zhihong Liu, Guoliang Zhang, Jihui Li, Hao Huang, Huan Zhou, Ming Liu, Wenning Zhu, Bin Huang, Shuyan Liu, Yuxin Ye, Xiaogang Niu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus maturation, dysregulation of host inflammation, and antiviral immune respon
Autor:
Hao Huang, Beihua Dong, Frank Sicheri, Yize Li, Robert H. Silverman, Jinle Tang, Christina Gaughan, Daniel Mao, Shuvojit Banerjee, Nicolas Tavernier, Gerald D. Gish, Manisha Talukdar, Salima Daou, Susan R. Weiss, Babal K. Jha, Abiodun A. Ogunjimi, Nicole M. Duffy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The OAS–RNase L system is an innate immunity pathway activated by viral infection. Viral dsRNA stimulates OAS enzymes to produce short 2′,5′-oligoadenylates (2-5A) that activate RNase L, resulting in cleavage of single-stranded (ss
Autor:
Ziyang Fu, Zhihong Liu, Yingjie Wang, Jihui Li, Yuxin Ye, Jinle Tang, Jiali Gao, Dante Neculai, Manisha Talukdar, Hao Huang, Huan Zhou
Publikováno v:
Biochemical Journal. 477:3387-3399
The pseudokinase (PK) RNase L is a functional ribonuclease and plays important roles in human innate immunity. The ribonuclease activity of RNase L can be regulated by the kinase inhibitor sunitinib. The combined use of oncolytic virus and sunitinib
Autor:
Jinle Tang, Zhengshuang Xu, Robert H. Silverman, Abhishek Asthana, Christina Gaughan, Guoliang Zhang, Hao Huang, Huan Zhou, Ming Liu, Beihua Dong, Xiaogang Niu, Shuyan Liu
Publikováno v:
Journal of medicinal chemistry. 65(2)
The pseudokinase-endoribonuclease RNase L plays important roles in antiviral innate immunity and is also implicated in many other cellular activities. The inhibition of RNase L showed therapeutic potential for Aicardi-Goutieres syndrome (AGS). Thus,
Autor:
Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease has been implicated in virus maturation, dysregulation of host inflammation and antiviral immune responses. We showed that PLpro preferably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f78589d342e21e7519c712edd0b2664
https://doi.org/10.1101/2020.07.17.208959
https://doi.org/10.1101/2020.07.17.208959
Autor:
Jiexin Zhang, Xingding Zhang, Dixie Lee Esseltine, Bart Barlogie, Lin Yang, Enrico Milan, Antje Hoering, Zhiqiang Wang, Heather Lin, John Crowley, Wen Cai Ma, Lin Qi, Simone Cenci, Hua Wang, Bin Li, Veerabhadran Baladandayuthapani, Donna M. Weber, Sheeba K. Thomas, Jianliang Xu, Jin He, Jing Yang, Qing Zhang, Hui Han Wang, Jinle Tang, Jatin J. Shah, Bing Zong Li, Robert Z. Orlowski, Elisabet E. Manasanch, Walter Hunziker, Isere Kuiatse, Richard E. Davis, Saad Z. Usmani, George Mulligan
Publikováno v:
Cancer Cell. 29:639-652
Proteasome inhibitors have revolutionized outcomes in multiple myeloma, but they are used empirically, and primary and secondary resistance are emerging problems. We have identified TJP1 as a determinant of plasma cell proteasome inhibitor susceptibi
Autor:
Jialu Li, Jinle Tang, Pengjun Jiang, Zhen-Yang Gu, Xuejun Zhu, Zhishu Gong, Yuan Yu, Juhua Yu, Huimin Meng, Dan Chen, Huyong Zheng, Xingding Zhang, Lin Yang, Gangli An, Lei Yuan, Lin Qi
Publikováno v:
Oncotarget
Various CD7-targeting immunotoxins have been tested for its potential in treating CD7+ malignant patients but none of those immunotoxins was approved clinically because of lacking enough efficacy and safety. Here we successfully constructed the monov
Autor:
Jinle Tang, Gangli An, Dan Chen, Lin Yang, Xingding Zhang, Yunhui Zong, Sisi Ye, Jianxuan Zou, Huimin Meng
Publikováno v:
Cancer Science
Bispecific antibodies play an important role in immunotherapy. They have received intense interest from pharmaceutical enterprises. The first antibody drug, OKT3 (muromonab-CD3), showed great performance in clinical treatment. We have successfully de