Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jinjing Che"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was utilized to develop a technique for the simultaneous quantification of icariin and its primary metabolites in mouse urine. The levels of icariin, icariside
Externí odkaz:
https://doaj.org/article/1c2dbf4a33314f24b2f4ebd5275e25c7
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Icariin, a Chinese medicinal herb with significant effects on Alzheimer’s disease, lacks pharmacokinetic data in mice. To address this, a UPLC-MS/MS method was developed and validated for quantifying Icariin and its metabolites, Icariside I and Ica
Externí odkaz:
https://doaj.org/article/81aef6546dc449b192f48f4b37e9d597
Publikováno v:
Molecules, Vol 28, Iss 4, p 1849 (2023)
The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified as a promising target for the treatment of influenza. To expand the chemical space of the known influenza polymerase PB2 inhibitor–pimodivir (formerly VX-787)
Externí odkaz:
https://doaj.org/article/bd1d0ff22f444f6093f3f5fe011cc35b
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Encapsulating the antisense oligonucleotide drug MK-ASODN with nanoliposomes greatly improved its potency and targeting to the heparin-binding growth factor midkine. The disposition and pharmacokinetic (PK) parameters of MK-ASODN nanoliposomes were s
Externí odkaz:
https://doaj.org/article/9080c8052a95453896fb0f55f2435f5e
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1789 (2022)
αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from Conus generalis, a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR)
Externí odkaz:
https://doaj.org/article/624a0a1f62184745a94f40087b8643a6
Autor:
Chuanxi Li, Yingying Ma, Xiao Liu, Renliang Huang, Rongxin Su, Wei Qi, Jinjing Che, Zhimin He
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 214, Iss , Pp 112115- (2021)
Nanoplastics (NPs) are becoming an emerging pollutant of global concern. A potential risk of NPs is that they can serve as carriers and synergistically function with other contaminants to cause diseases. A variety of diseases such as Alzheimer’s di
Externí odkaz:
https://doaj.org/article/1ec26d4143284fa284f6bb1733b75dbe
Publikováno v:
Molecules, Vol 26, Iss 22, p 6944 (2021)
Influenza A virus is the main cause of worldwide epidemics and annual influenza outbreaks in humans. In this study, a virtual screen was performed to identify compounds that interact with the PB2 cap-binding domain (CBD) of influenza A polymerase. A
Externí odkaz:
https://doaj.org/article/69117a614db3484cbfd8d337b0ade3c6
Autor:
Lei Zhao, Jinjing Che, Qian Zhang, Yiming Li, Xiaojia Guo, Lixia Chen, Hua Li, Ruiyuan Cao, Xingzhou Li
Publikováno v:
Molecules, Vol 25, Iss 22, p 5291 (2020)
To discover novel inhibitors that target the influenza polymerase basic protein 2 (PB2) cap-binding domain (CBD), commercial ChemBridge compound libraries containing 384,796 compounds were screened using a cascade docking of LibDock–LigandFit–GOL
Externí odkaz:
https://doaj.org/article/e25e90224f5641dab95afef486c297bf
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171567 (2017)
Most mechanistic studies on human immunodeficiency virus (HIV) peptide fusion inhibitors have focused on the interactions between fusion inhibitors and viral envelope proteins. However, the interactions of fusion inhibitors with viral membranes are a
Externí odkaz:
https://doaj.org/article/37b3b35df50d43c4be79ca1c9b57210a
Autor:
Chenguang Cai, Jinjing Che, Long Xu, Qiang Guo, Yirong Kong, Ling Fu, Junjie Xu, Yuanguo Cheng, Wei Chen
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20646 (2011)
Anthrax toxin is the major virulence factor produced by Bacillus anthracis. The toxin consists of three protein subunits: protective antigen (PA), lethal factor, and edema factor. Inhibition of PA binding to its receptors, tumor endothelium marker-8
Externí odkaz:
https://doaj.org/article/921ada67cec147d497c7f6121ee819ac