Phytocannabinoids, the Endocannabinoid System and Male Reproduction

Autor: Jinhwan Lim, Erica Squire, Kwang-Mook Jung

Publikováno v: The World Journal of Men's Health, Vol 41, Iss 1, Pp 1-13 (2023)

The endocannabinoid system (ECS) is comprised of a set of lipid-derived messengers (the endocannabinoids, ECBs), proteins that control their production and degradation, and cell-surface cannabinoid (CB) receptors that transduce their actions. ECB m

Externí odkaz: https://doaj.org/article/27d01ab33688416f9338268b642d95d4

Adolescent exposure to low-dose Δ9-tetrahydrocannabinol depletes the ovarian reserve in female mice

Autor: Jinhwan Lim, Hye-Lim Lee, Julie Nguyen, Joyce Shin, Samantha Getze, Caitlin Quach, Erica Squire, Kwang-Mook Jung, Stephen V Mahler, Ken Mackie, Daniele Piomelli, Ulrike Luderer

Publikováno v: Toxicological Sciences. 193:31-47

Cannabis use by adolescents is widespread, but its effects on the ovaries remain largely unknown. Δ9-tetrahydrocannabinol (THC) exerts its pharmacological effects by activating, and in some conditions hijacking, cannabinoid receptors (CBRs). We hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bcfcbb08950f9b7fd8e89230fbb2509
https://doi.org/10.1093/toxsci/kfad027

Sex Differences in Embryonic Gonad Transcriptomes and Benzo[a]pyrene Metabolite Levels After Transplacental Exposure

Autor: Ulrike Luderer, Jinhwan Lim, Kathleen Leon Parada, Aramandla Ramesh, Toshi Shioda

Publikováno v: Endocrinology

Polycyclic aromatic hydrocarbons like benzo[a]pyrene (BaP) are generated during incomplete combustion of organic materials. Prior research has demonstrated that BaP is a prenatal ovarian toxicant and carcinogen. However, the metabolic pathways active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f115760bbbb4e768efece72445950
https://doi.org/10.1210/endocr/bqab228

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

Autor: Yoon J. Lee, Jinhwan Lim, Bo Youn Choi, Jae Hoon Sul, Jin Su Park, Jihoon Han, Gahee Bahn, Jeung Whan Han, Mark P. Mattson, Ui Jeong Yun, Thiruma V. Arumugam, Sang-Ha Baik, Jong-Sung Park, Yoon Suk Cho, Soo Han Bae, Hark Kyun Kim, Seung Hyun Baek, Dong-Gyu Jo, Yuri Choi, Nobunao Wakabayashi

Publikováno v: Proceedings of the National Academy of Sciences. 116:12516-12523

Significance Considering that Alzheimer’s disease (AD) is a chronic disease progressing over a long period of time, even a slight increase of BACE1 expression may have a profound effect on Aβ accumulation. We describe a previously unknown mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25248fd7dcb62ee97a9638f3aa9a83e
https://doi.org/10.1073/pnas.1819541116

Glutathione-Deficient Mice Have Increased Sensitivity to Transplacental Benzo[a]pyrene-Induced Premature Ovarian Failure and Ovarian Tumorigenesis

Autor: Jinhwan Lim, Brooke N. Nakamura, Laura Ortiz, Ulrike Luderer, Gregory W. Lawson, Terrance J. Kavanagh, Jin A. Hur

Publikováno v: Lim, J; Lawson, GW; Nakamura, BN; Ortiz, L; Hur, JA; Kavanagh, TJ; et al.(2013). Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis. Cancer Research, 73(2), 908-917. doi: 10.1158/0008-5472.CAN-12-3636. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4tx304vn

Polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (BaP) are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Prenatal exposure to BaP causes premature reproductive senescence in mice, and other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4481d6257ead8911b308ba236971a01
https://doi.org/10.1158/0008-5472.can-12-3636