Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jinhua Bayford"'
Autor:
Natalia Izotova, Christine Rivat, Cristina Baricordi, Elena Blanco, Danilo Pellin, Eleanor Watt, Athina S. Gkazi, Stuart Adams, Kimberly Gilmour, Jinhua Bayford, Claire Booth, H. Bobby Gaspar, Adrian J. Thrasher, Luca Biasco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Gene therapy (GT) using haematopoietic stem cells (HSCs) provides an opportunity to trace cell fates in humans, in vivo. Here the authors present evidence in GT patients for a long term lymphoid progenitor population, surviving and maintaining de nov
Externí odkaz:
https://doaj.org/article/dced9d3e9d5c441eaba1bc9789351905
Autor:
Frank J. T. Staal, Fang Zhang, Jinhua Bayford, Manuela Wissler, Adrian J. Thrasher, H. Bobby Gaspar, Rachel Peraj, Hanno Glimm, Kerstin Schwarzwaelder, Martijn H. Brugman, Steven J. Howe, Annette Deichmann, Sonja Schmidt, Joanna Sinclair, Gerard Wagemaker, Ulrich Abel, Douglas King, Kathryn L. Parsley, Manfred Schmidt, Claudia Prinz, Christof von Kalle, Kimberly Gilmour, Christine Kinnon, Karin Pike-Overzet, Dick de Ridder
Publikováno v:
Journal of Clinical Investigation, 117(8), 2241-2249. The American Society for Clinical Investigation
We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene transfer. Those with sufficient follow-up were found to have recovered substantial immunity in the absence of any serious adverse events up to 5 years after treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4337a356b1231049d977eb4bf5e70605
https://pure.eur.nl/en/publications/8968aad0-6d43-4abd-bde6-d9560b9d1377
https://pure.eur.nl/en/publications/8968aad0-6d43-4abd-bde6-d9560b9d1377
Autor:
Cynthia C. Bartholomae, Rosemary E. Gale, Marc R. Mansour, H. Bobby Gaspar, Martijn H. Brugman, Kerstin Schwarzwaelder, Kimberly Gilmour, Christof von Kalle, Dick de Ridder, Frank J. T. Staal, Stuart Adams, S Chatters, Helena Kempski, David Webb, Kathryn L. Parsley, Manfred Schmidt, Philip Ancliff, Susannah I. Thornhill, Mike Hubank, Christine Kinnon, David C. Linch, Karin Pike-Overzet, Michelle Quaye, Lucie Brown, Jinhua Bayford, Steven J. Howe, Adrian J. Thrasher
Publikováno v:
Journal of Clinical Investigation, 118(9), 3143-3150. The American Society for Clinical Investigation
X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional gammaretroviral vectors. Here, we describe the occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL) promoted by insertional mutagenesis in a completed ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57c969af41717e39674dd69b1efbfe2
https://pubmed.ncbi.nlm.nih.gov/18688286
https://pubmed.ncbi.nlm.nih.gov/18688286
Autor:
Adrian J. Thrasher, L Brown, Lynette D. Fairbanks, Jinhua Bayford, Emma Bjorkegren, Fang Zhang, Paul Veys, Christine Kinnon, E. Graham Davies, Samantha Cooray, Victoria Bordon, Theoni Petropoulou, Kathryn L. Parsley, Kimberly Gilmour, Stuart Adams, H. Bobby Gaspar
Publikováno v:
Science Translational Medicine; Vol 3
Genetic defects in the purine salvage enzyme adenosine deaminase (ADA) lead to severe combined immunodeficiency (SCID) with profound depletion of T, B, and natural killer cell lineages. Human leukocyte antigen-matched allogeneic hematopoietic stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41598068938f32e53dcc85eef1bc7b0
Autor:
H. Bobby Gaspar, Kathryn L. Parsley, Jinhua Bayford, Samantha Cooray, Kimberly Gilmour, Abdulaziz Al Ghonaium, Christine Kinnon, E. Graham Davies, Adrian J. Thrasher, Steven J. Howe, Stuart Adams, L Brown
Publikováno v:
Science Translational Medicine; Vol 3
X-linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the common cytokine receptor γ chain. These mutations classically lead to complete absence of functional T and natural killer cell lineages as well as to intrinsically com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760a1097f76bfc16bbe0b37f85514ca3