Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Jinhu Xiong"'
Autor:
Ryan S MacLeod, Mark B Meyer, Jinhu Xiong, Keisha M Cawley, Yu Liu, Melda Onal, Nancy A Benkusky, Jeff D Thostenson, J Wesley Pike, Charles A O'Brien
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250974 (2021)
The cytokine RANKL is essential for osteoclast formation during physiological and pathological bone resorption. RANKL also contributes to lymphocyte production, development of lymph nodes and mammary glands, as well as other biological activities. Tr
Externí odkaz:
https://doaj.org/article/4047ea3d5756425eb485380cdefc3d75
Autor:
Ha-Neui Kim, Jinhu Xiong, Ryan S. MacLeod, Srividhya Iyer, Yuko Fujiwara, Keisha M. Cawley, Li Han, Yonghan He, Jeff D. Thostenson, Elisabeth Ferreira, Robert L. Jilka, Daohong Zhou, Maria Almeida, Charles A. O’Brien
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encod
Externí odkaz:
https://doaj.org/article/657c52f5dd0742dba28700a3da2de806
Autor:
Jinhu Xiong, Keisha Cawley, Marilina Piemontese, Yuko Fujiwara, Haibo Zhao, Joseph J. Goellner, Charles A. O’Brien
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.
Externí odkaz:
https://doaj.org/article/f3fdb2bc80d5499aa847b891e2ea7b50
Publikováno v:
eLife, Vol 8 (2019)
Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside in bone matrix, sense changes in mechanical load, and produce signals th
Externí odkaz:
https://doaj.org/article/82f9104b7d27429db877677ba7dd57ab
Autor:
Jinhu Xiong, Marilina Piemontese, Melda Onal, Josh Campbell, Joseph J Goellner, Vladimir Dusevich, Lynda Bonewald, Stavros C Manolagas, Charles A O'Brien
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138189 (2015)
The cytokine receptor activator of nuclear factor kappa B ligand (RANKL), encoded by the Tnfsf11 gene, is essential for osteoclastogenesis and previous studies have shown that deletion of the Tnfsf11 gene using a Dmp1-Cre transgene reduces osteoclast
Externí odkaz:
https://doaj.org/article/35f70f5672144557a69c5e41b87ba366
Autor:
Nookaew, Intawat1,2 inookaew@uams.edu, Jinhu Xiong1,3, Onal, Melda1,4, Bustamante-Gomez, Cecile1,5, Wanchai, Visanu2, Qiang Fu1,5, Ha-Neui Kim1,5, Almeida, Maria1,3,5, O'Brien, Charles A.1,3,5,6 caobrien@uams.edu
Publikováno v:
Journal of Biological Chemistry. Apr2024, Vol. 300 Issue 4, p1-15. 15p.
Autor:
Xuehua Li, Connie Zhang, Hayden H. Bowman, Jeffrey B. Stambough, Benjamin M. Stronach, Simon C. Mears, Lowry C. Barnes, Elena Ambrogini, Jinhu Xiong
Publikováno v:
Aging Cell.
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(10)
Mechanical signals stimulate mitochondrial function but the molecular mechanisms are not clear. Here, we show that the mechanically sensitive ion channel Piezo1 plays a critical role in mitochondrial adaptation to mechanical stimulation. The activati
Publikováno v:
Canadian Association of Radiologists Journal. 72:242-250
Objective: To determine whether there is added benefit for 3D mammography in the context of screening and diagnostic imaging, particularly relating to known prognostic characteristics, including histopathology, receptor status, and axillary lymph nod
Autor:
Yonghan He, Yuko Fujiwara, Li Han, Keisha M. Cawley, Daohong Zhou, Jinhu Xiong, Ha-Neui Kim, Ryan S. MacLeod, Charles A. O'Brien, Maria Almeida, Elisabeth Ferreira, Robert L. Jilka, Srividhya Iyer, Jeff D. Thostenson
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 19 (2020)
JCI Insight, Vol 5, Iss 19 (2020)
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encod