Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Jinhong Chang"'
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1545-1554 (2021)
The prolonged viral antigen stimulation is the driving force for the development of immune tolerance to chronic hepatitis B virus (HBV) infection. The sustained reduction of viral proteins may allow for the recovery and efficient activation of HBV-sp
Externí odkaz:
https://doaj.org/article/c22cb7acfba643bc8b15345d3d067874
Autor:
Jin Hu, Liudi Tang, Junjun Cheng, Tianlun Zhou, Yuhuan Li, Jinhong Chang, Qiong Zhao, Ju-Tao Guo
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 852-864 (2021)
Upon infection of hepatocyte, Hepatitis B virus (HBV) genomic DNA in nucleocapsid is transported into the nucleus and converted into a covalently closed circular (ccc) DNA to serve as the template for transcription of viral RNAs. Viral DNA in the cyt
Externí odkaz:
https://doaj.org/article/84f2056ed9454aef847c9297d361f340
Autor:
Zhao Gao, Xuexiang Zhang, Lin Zhang, Shuo Wu, Julia Ma, Fuxuan Wang, Yan Zhou, Xinghong Dai, Esther Bullitt, Yanming Du, Ju-Tao Guo, Jinhong Chang
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010271 (2022)
Flavivirus infection of cells induces massive rearrangements of the endoplasmic reticulum (ER) membrane to form viral replication organelles (ROs) which segregates viral RNA replication intermediates from the cytoplasmic RNA sensors. Among other vira
Externí odkaz:
https://doaj.org/article/9acdec3399584bd980f30dcfeef6e79c
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
The core protein (Cp) of hepatitis B virus (HBV) assembles pregenomic RNA (pgRNA) and viral DNA polymerase to form nucleocapsids where the reverse transcriptional viral DNA replication takes place. Core protein allosteric modulators (CpAMs) inhibit H
Externí odkaz:
https://doaj.org/article/383a29cee9b741dd8320723f9d5d4a71
Autor:
Danying Chen, Zhifei Hou, Dong Jiang, Mei Zheng, Guoli Li, Yue Zhang, Rui Li, Hanxin Lin, Jinhong Chang, Hui Zeng, Ju-Tao Guo, Xuesen Zhao
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1511-1523 (2019)
ABSTRACTInterferons (IFNs) control viral infections by inducing expression of IFN-stimulated genes (ISGs) that restrict distinct steps of viral replication. We report herein that gamma-interferon-inducible lysosomal thiol reductase (GILT), a lysosome
Externí odkaz:
https://doaj.org/article/f22fd231b9944beba50e35e378fd1e9b
Autor:
Fengtao Luo, Yangli Xie, Zuqiang Wang, Junlan Huang, Qiaoyan Tan, Xianding Sun, Fangfang Li, Can Li, Mi Liu, Dali Zhang, Meng Xu, Nan Su, Zhenhong Ni, Wanling Jiang, Jinhong Chang, Hangang Chen, Shuai Chen, Xiaoling Xu, Chuxia Deng, Zhugang Wang, Xiaolan Du, Lin Chen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 291-302 (2018)
Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations including Pro253Arg(P253R) of fibroblast growth factor receptor 2 (FGFR2), which leads to enhanced FGF/FGFR2-signaling activity. Surgical correction of the
Externí odkaz:
https://doaj.org/article/55f81181c9a746ffbc319446daa5eb4e
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008669 (2020)
Hepatitis B virus (HBV) replicates its genomic DNA via viral DNA polymerase self-primed reverse transcription of a RNA pre-genome in the nucleocapsid assembled by 120 core protein (Cp) dimers. The arginine-rich carboxyl-terminal domain (CTD) of Cp pl
Externí odkaz:
https://doaj.org/article/d61fe61bb14b4832a7afb06f44f38204
Autor:
Harish N. Ramanathan, Shuo Zhang, Florian Douam, Katrina B. Mar, Jinhong Chang, Priscilla L. Yang, John W. Schoggins, Alexander Ploss, Brett D. Lindenbach
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA replication, such as nucleocapsid disassembly. We describe here a sensitive, conditionally replication-def
Externí odkaz:
https://doaj.org/article/aee8a1244e744296af80d6a1ac424a93
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007742 (2019)
Persistent hepatitis B virus (HBV) infection relies on the establishment and maintenance of covalently closed circular (ccc) DNA, a 3.2 kb episome that serves as a viral transcription template, in the nucleus of an infected hepatocyte. Although evide
Externí odkaz:
https://doaj.org/article/cd51b72780654ee6aa66c4868869bc6b
Autor:
Shuo Zhang, Harish N. Ramanathan, Florian Douam, Katrina B. Mar, Jinhong Chang, Priscilla L. Yang, John W. Schoggins, Alexander Ploss, Brett D. Lindenbach
Publikováno v:
Proceedings, Vol 50, Iss 1, p 147 (2020)
Flaviviruses are enveloped, arthropod-borne, positive-strand RNA viruses that cause significant human disease. While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA repl
Externí odkaz:
https://doaj.org/article/984d15be1f774ed1a286468fcf678702