Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Jinhan He"'
Autor:
Jinhang Zhang, Ya Huang, Hong Li, Pengfei Xu, Qinhui Liu, Yang Sun, Zijing Zhang, Tong Wu, Qin Tang, Qingyi Jia, Yan Xia, Ying Xu, Xiandan Jing, Jiahui Li, Li Mo, Wen Xie, Aijuan Qu, Jinhan He, Yanping Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of intestinal PXR in metabolic diseases remains largely unknown. Here,
Externí odkaz:
https://doaj.org/article/c585118dd2cb442cb8c2dbc63eae7924
Autor:
Ying Xu, Yan Xia, Qinhui Liu, Xiandan Jing, Qin Tang, Jinhang Zhang, Qingyi Jia, Zijing Zhang, Jiahui Li, Jiahao Chen, Yimin Xiong, Yanping Li, Jinhan He
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 12, Pp 1548-1561 (2023)
Excessive N-acetyl-p-benzoquinone imine (NAPQI) formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen (APAP) overdose caused acute liver failure (ALF). S-glutathionylation is a reversible red
Externí odkaz:
https://doaj.org/article/063c7bc8b2f447eda513b9fc63f26214
Autor:
Teng Huang, Jia Song, Jia Gao, Jia Cheng, Hao Xie, Lu Zhang, Yu-Han Wang, Zhichao Gao, Yi Wang, Xiaohui Wang, Jinhan He, Shiwei Liu, Qilin Yu, Shu Zhang, Fei Xiong, Qing Zhou, Cong-Yi Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Kynurenine, a tryptophan metabolite, is increased in the circulating plasma of obese individuals, but the source has been unclear. Here, the authors show in mice that mature adipocytes produce kynurenine, with vitamin B6 administration preventing acc
Externí odkaz:
https://doaj.org/article/182bc1cde73f4b90bf23677b8dd10ad5
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER str
Externí odkaz:
https://doaj.org/article/28954ef646534ea88b9740fd0b33491d
Publikováno v:
Molecules, Vol 28, Iss 15, p 5801 (2023)
The aberrant expansion of GGGGCC hexanucleotide repeats within the first intron of the C9orf72 gene represent the predominant genetic etiology underlying amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). The transcribed r(GGGGC
Externí odkaz:
https://doaj.org/article/9a4178a4a2c94983aa021389830c4e2d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic patients worldwide. DN is associated with proteinuria and progressive slowing of glomerular filtration, which often leads to end-stage kidney diseases. Due to
Externí odkaz:
https://doaj.org/article/3494ddfa587b4c88a959ebc253ce9516
Autor:
Xuping Yang, Qinhui Liu, Yanping Li, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Yingnan Zhao, Guorong Zhang, Cuiyuan Huang, Jinhang Zhang, Zijing Zhang, Ya Huang, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan He
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 484-494 (2020)
The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary glucose excretion and thus reducing hyperglycaemia. Cana treatment also reduces body weight. However, it remains unclear w
Externí odkaz:
https://doaj.org/article/6af5c4ed9b494dcbaec0f4ee17d251b8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and even cancer. The US Food and Drug Administration has not
Externí odkaz:
https://doaj.org/article/58f517150ba14c2e9fbd90e1f5c13c15
Autor:
Jian Zhou, Rui Li, Qinhui Liu, Jinhang Zhang, Hui Huang, Cuiyuan Huang, Guorong Zhang, Yingnan Zhao, Tong Wu, Qin Tang, Ya Huang, Zijing Zhang, Yanping Li, Jinhan He
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss , Pp 111470- (2021)
The enzyme 5-lipoxygenase (5-LO) converts arachidonic acid to leukotrienes, which mediate inflammation. The enzyme is known to contribute to organ fibrosis, but how it contributes to renal fibrosis is unclear. Here, we reported that fibrotic kidneys
Externí odkaz:
https://doaj.org/article/28feb3e5b0434afc9a95682d89887458
Autor:
Shiyun Pu, Yanping Li, Qinhui Liu, Xu Zhang, Lei Chen, Rui Li, Jinhang Zhang, Tong Wu, Qin Tang, Xuping Yang, Zijing Zhang, Ya Huang, Jiangying Kuang, Hong Li, Min Zou, Wei Jiang, Jinhan He
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes. In this study, we examined the role of 5-LO in HSC ac
Externí odkaz:
https://doaj.org/article/5d4b3915c3bf4b0ebd852a77c304c260