Výsledky vyhledávání - "Jingzhu Liao"

Akademický článek

Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia

Autor: Jingzhu Liao, Geyao Dong, Wenjun Zhu, Bolati Wulaer, Hiroyuki Mizoguchi, Masahito Sawahata, Yue Liu, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

Publikováno v: Pharmacological Research, Vol 194, Iss , Pp 106838- (2023)

Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic treatment in SCZ improves positive symptoms but has major side effects and little impact on nega

Externí odkaz: https://doaj.org/article/a630b78de7834853846b1611a306f2b9

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Akademický článek

Structure Characterization of Honey-Processed Astragalus Polysaccharides and Its Anti-Inflammatory Activity In Vitro

Autor: Jingzhu Liao, Chanyi Li, Jing Huang, Wuping Liu, Hongce Chen, Shuangye Liao, Hongyuan Chen, Wen Rui

Publikováno v: Molecules, Vol 23, Iss 1, p 168 (2018)

Honey-processed Astragalus is a dosage form of Radix Astragalus mixed with honey by a traditional Chinese medicine processing method which strengthens the tonic effect. Astragalus polysaccharide (APS), perform its immunomodulatory effects by relying

Externí odkaz: https://doaj.org/article/5975e3d9332a4ef787c5869c63f5f9e4

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Rho kinase inhibitors ameliorate acute methamphetamine-induced cognitive impairment through the cortico-striatal circuit in mice

Autor: Jingzhu Liao, Bolati Wulaer, Hiroyuki Mizoguchi, Masahito Sawahata, Yue Liu, Geyao Dong, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Although its pathoetiology remains unclear, it is known to involve small GTPase signaling. Rho kinase, an effector of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8ad99d9ad8c19bb7303ff835eff21dd
https://doi.org/10.22541/au.166439569.90753669/v1

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Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia

Autor: Saeko Takase, Jingzhu Liao, Yue Liu, Rinako Tanaka, Yasuhiro Miyagawa, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Taku Nagai, Kozo Kaibuchi, Norio Ozaki, Kiyofumi Yamada

Publikováno v: European journal of pharmacology. 931

Current antipsychotics used to treat schizophrenia have associated problems, including serious side effects and treatment resistance. We recently identified a significant association of schizophrenia with exonic copy number variations in the Rho GTPa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808d966fa36c0904d5cc4c0ac0dbfcd2
https://pubmed.ncbi.nlm.nih.gov/35987254

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Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Autor: Naofumi Uesaka, Norio Ozaki, Bolati Wulaer, Taku Nagai, Yoshitaka Fukada, Kimiko Shimizu, Ryo Saito, Atsu Aiba, Jingzhu Liao, Kazuaki Maruyama, Michinori Koebis, Masanobu Kano, Kazuki Nakao, Yuki Sugaya, Hiroki Kurihara, Kiyofumi Yamada, Itaru Kushima, Daisuke Mori, Kenichiro Nagahama

Publikováno v: Translational Psychiatry, Vol 10, Iss 1, Pp 1-13 (2020)
Translational Psychiatry

The 22q11.2 deletion syndrome (22q11.2DS) is associated with an increased risk for psychiatric disorders. Although most of the 22q11.2DS patients have a 3.0-Mb deletion, existing mouse models only mimic a minor mutation of 22q11.2DS, a 1.5-Mb deletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871d888d26241ed62c15bd39621bb18f
http://link.springer.com/article/10.1038/s41398-020-0723-z

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Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene

Autor: Rinako Tanaka, Jingzhu Liao, Kazuhiro Hada, Daisuke Mori, Taku Nagai, Tetsuo Matsuzaki, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

Publikováno v: Pharmacological Research. 187:106589

Copy-number variations in the ARHGAP10 gene encoding Rho GTPase-activating protein 10 are associated with schizophrenia. Model mice (Arhgap10 S490P/NHEJ mice) that carry "double-hit" mutations in the Arhgap10 gene mimic the schizophrenia in a Japanes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41857ffce0f4fd24fd01f59867f0f0cb
https://doi.org/10.1016/j.phrs.2022.106589

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Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks

Autor: Kiyofumi Yamada, Norio Ozaki, Geyao Dong, Masahito Sawahata, Bolati Wulaer, Jingzhu Liao, Toshitaka Nabeshima, Hiroyuki Mizoguchi, Taku Nagai, Daisuke Mori

Publikováno v: Behavioural brain research. 416

The Reelin gene (RELN) encodes a large extracellular protein, which has multiple roles in brain development and adult brain function. It activates a series of neuronal signal transduction pathways in the adult brain that function in synaptic plastici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb9f7514d23268a80f72cf029397926
https://pubmed.ncbi.nlm.nih.gov/34499931

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Application of pathways activity profiling to urine metabolomics for screening Qi-tonifying biomarkers and metabolic pathways of honey-processed Astragalus

Autor: Wenjie Ma, Jingzhu Liao, Wuping Liu, Wen Rui, Chanyi Li, Jing Huang, Hongyuan Chen, Shuangye Liao

Publikováno v: Journal of Separation Science. 41:2661-2671

Honey-processed Astragalus, a widely used Qi-tonifying and immunomodulating herb in traditional Chinese medicine, has strengthened the tonic effects and achieved fewer side effects compared with astragali radix in clinical application. Here, we focus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c46503828a1e051a624ff51008006c6
https://doi.org/10.1002/jssc.201701371

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