Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Jingyue Ju"'
Autor:
Xammy Nguyenla, Eddie Wehri, Erik Van Dis, Scott B. Biering, Livia H. Yamashiro, Chi Zhu, Julien Stroumza, Claire Dugast-Darzacq, Thomas G. W. Graham, Xuanting Wang, Steffen Jockusch, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, James J. Russo, Jingyue Ju, Anders M. Näär, Sarah Stanley, Julia Schaletzky
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum antiviral nucleoside analog. Efficac
Externí odkaz:
https://doaj.org/article/9e4aeb4597b84bd5b8c7f7298e96338a
Autor:
Xuanting Wang, Carolina Q. Sacramento, Steffen Jockusch, Otávio Augusto Chaves, Chuanjuan Tao, Natalia Fintelman-Rodrigues, Minchen Chien, Jairo R. Temerozo, Xiaoxu Li, Shiv Kumar, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, Patrícia T. Bozza, James J. Russo, Thiago Moreno L. Souza, Jingyue Ju
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
In this paper, the hepatitis C virus inhibitors Pibrentasvir and Ombitasvir are found to inhibit the SARS-CoV-2 exonuclease and are shown to have therapeutic potential when combined with SARS-CoV-2 polymerase inhibitors in viral cell cultures.
Externí odkaz:
https://doaj.org/article/421885d8a61b464da42eeec94cc924d8
Autor:
Xuanting Wang, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Xiaoxu Li, Shiv Kumar, James J. Russo, Jingyue Ju
Publikováno v:
Viruses, Vol 14, Iss 7, p 1413 (2022)
With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to develop effective and variant-resistant oral drugs. Recently, we reported in vitro results validating the use of combination drugs targeting both the SARS-CoV-2
Externí odkaz:
https://doaj.org/article/8e3ba3b436bf417782aed55d391c5f4a
Autor:
Otávio Augusto Chaves, Natalia Fintelman-Rodrigues, Xuanting Wang, Carolina Q. Sacramento, Jairo R. Temerozo, André C. Ferreira, Mayara Mattos, Filipe Pereira-Dutra, Patrícia T. Bozza, Hugo Caire Castro-Faria-Neto, James J. Russo, Jingyue Ju, Thiago Moreno L. Souza
Publikováno v:
Viruses, Vol 14, Iss 7, p 1458 (2022)
Despite the fast development of vaccines, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still circulating and generating variants of concern (VoC) that escape the humoral immune response. In this context, the search for anti-SARS-Co
Externí odkaz:
https://doaj.org/article/3d78c0a321244c66a6911f5bba741dc1
Autor:
Jingyue Ju, Xiaoxu Li, Shiv Kumar, Steffen Jockusch, Minchen Chien, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Robert N. Kirchdoerfer, James J. Russo
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
Abstract SARS‐CoV‐2, a member of the coronavirus family, has caused a global public health emergency. Based on our analysis of hepatitis C virus and coronavirus replication, and the molecular structures and activities of viral inhibitors, we prev
Externí odkaz:
https://doaj.org/article/c4e280e62da0401999fbdd345e4fd779
Autor:
Gustavo Palacios, Thomas Briese, Vishal Kapoor, Omar Jabado, Zhiqiang Liu, Marietjie Venter, Junhui Zhai, Neil Renwick, Allen Grolla, Thomas W. Geisbert, Christian Drosten, Jonathan S. Towner, Jingyue Ju, Janusz Paweska, Stuart T. Nichol, Robert Swanepoel, Heinz Feldmann, Peter B. Jahrling, W. Ian Lipkin
Publikováno v:
Emerging Infectious Diseases, Vol 12, Iss 4, Pp 692-695 (2006)
Viral hemorrhagic fevers are associated with high rates of illness and death. Although therapeutic options are limited, early differential diagnosis has implications for containment and may aid in clinical management. We describe a diagnostic system
Externí odkaz:
https://doaj.org/article/5242d0e8825c473192bc0647c707b5e4
Autor:
Yaguang Xi, Andrea Formentini, Minchen Chien, David B. Weir, James J. Russo, Jingyue Ju, Marko Kornmann, Jingfang Ju
Publikováno v:
Biomarker Insights, Vol 1, Pp 113-121 (2006)
The functions of non-coding microRNAs (miRNAs) in tumorigenesis are just beginning to emerge. Previous studies from our laboratory have identifi ed a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tum
Externí odkaz:
https://doaj.org/article/4d8c1d4148324cf3904f3daa9ee4f398
Autor:
Thomas Briese, Gustavo Palacios, Mark Kokoris, Omar Jabado, Zhiqiang Liu, Neil Renwick, Vishal Kapoor, Inmaculada Casas, Francisco Pozo, Ron Limberger, Pilar Perez-Brena, Jingyue Ju, W. Ian Lipkin
Publikováno v:
Emerging Infectious Diseases, Vol 11, Iss 2, Pp 310-313 (2005)
Naturally emerging and deliberately released pathogens demand new detection strategies to allow early recognition and containment. We describe a diagnostic system for rapid, sensitive, multiplex discrimination of microbial gene sequences and report i
Externí odkaz:
https://doaj.org/article/04fa5c00a7ef4356ac223e1d5261fffc
Autor:
Camila R. R. Pão, Thomas Tuschl, Aitor Garzia, Lucas Villas Bôas Hoelz, Felipe Betoni Saraiva, Suelen da Silva Gomes Dias, Dumith Chequer Bou-Habib, Frederico Silva Castelo Branco, Wei Xie, Jingyue Ju, Chuanjuan Tao, Vinicius Cardoso Soares, André C. Ferreira, Stevens K. Rehen, Jairo R. Temerozo, Caroline S. de Freitas, Carine dos Santos da Silva, Carolina Q. Sacramento, Marília Zaluar P. Guimarães, Andrew Owen, Thiago Moreno L. Souza, Patrícia T. Bozza, Xuanting Wang, Nubia Boechat, Mayara Mattos, Rajith K. R. Rajoli, Dinshaw J. Patel, Steffen Jockusch, Marcelo Alves Ferreira, Fernando A. Bozza, Natalia Fintelman-Rodrigues, Gabriela Vitória, Livia Goto-Silva, Tácio Vinício Amorim Fernandes, Aline de Paula Dias Da Silva, Mônica M. Bastos, Carolina da S. G. Pedrosa, Leticia R. Q. Souza, James J. Russo, Minchen Chien
Publikováno v:
Journal of Antimicrobial Chemotherapy
Background Current approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. SARS-CoV-2 nsp12, its RNA polymerase, shares homology in the nucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba3878b9eb5f2dd7bdc20ace00f834b
https://doi.org/10.1093/jac/dkab072
https://doi.org/10.1093/jac/dkab072
Autor:
Chuanjuan Tao, Xiaoxu Li, Steffen Jockusch, Irina Morozova, Shiv Kumar, Minchen Chien, Sergey Kalachikov, James J. Russo, Jingyue Ju
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic in over a hundred years. After examining the molecular structures and activities of hepatitis C viral inhibitors and comparing hepatitis C virus and coronavirus replication, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b61c7385a1d037cb2cd389835d86af
http://link.springer.com/article/10.1038/s41598-020-73641-9
http://link.springer.com/article/10.1038/s41598-020-73641-9